The Impact of Healthy Lifestyles on Late Sequelae in Classical Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma Survivors. A Systematic Review by the Fondazione Italiana Linfomi
Background: In recent years, the scientific community has been paying ever more attention to the promotion of lifestyles aimed at the prevention of late toxicities related to anti-cancer treatments. Methods: Fondazione Italiana Linfomi (FIL) researchers conducted a systematic review in order to eval...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/13/3135 |
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| author | Carla Minoia Chiara Gerardi Eleonora Allocati Antonella Daniele Vitaliana De Sanctis Alessia Bari Attilio Guarini |
| author_facet | Carla Minoia Chiara Gerardi Eleonora Allocati Antonella Daniele Vitaliana De Sanctis Alessia Bari Attilio Guarini |
| author_sort | Carla Minoia |
| collection | DOAJ |
| description | Background: In recent years, the scientific community has been paying ever more attention to the promotion of lifestyles aimed at the prevention of late toxicities related to anti-cancer treatments. Methods: Fondazione Italiana Linfomi (FIL) researchers conducted a systematic review in order to evaluate the evidence in favor of the promotion of lifestyles aimed at the prevention of the main sequelae of long-term classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL) in survivors treated at adulthood with first-line or second-line therapy, including autologous stem cell transplants (ASCTs). Pubmed, Embase and Cochrane Library were searched up to December 2020. Results: Seven studies were ultimately included in this systematic review; some of them were eligible for multiple PICOS. The majority of the studies emerged from data extraction regarding cHL; less evidence resulted for DLBCL survivors. Five studies in favor of physical activity provided consistent data for a reduction of the cardiovascular risk in cHL and also in survivors who underwent ASCT. A beneficial effect of physical activity in reducing chronic fatigue was found. Being overweight was associated with a higher risk of coronary heart disease in cHL survivors in one of the two eligible studies. Studies aiming to evaluate the impact of the Mediterranean diet on late toxicities and secondary cancers were lacking. Tailored survivorship care plans (SCP) seemed to represent an optimal tool to guide the follow-up and promote healthier lifestyles in the one eligible study. Thus, promotion of healthy lifestyles and empowering of lymphoma survivors should be implemented through structured models. The study also brought to light numerous areas of future clinical research. |
| first_indexed | 2024-03-10T10:08:34Z |
| format | Article |
| id | doaj.art-7de3f0499a154a58b0f23d807d49f282 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T10:08:34Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7de3f0499a154a58b0f23d807d49f2822023-11-22T01:21:05ZengMDPI AGCancers2072-66942021-06-011313313510.3390/cancers13133135The Impact of Healthy Lifestyles on Late Sequelae in Classical Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma Survivors. A Systematic Review by the Fondazione Italiana LinfomiCarla Minoia0Chiara Gerardi1Eleonora Allocati2Antonella Daniele3Vitaliana De Sanctis4Alessia Bari5Attilio Guarini6Hematology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyIstituto di Ricerche Farmacologiche “Mario Negri” IRCCS, 20156 Milano, ItalyIstituto di Ricerche Farmacologiche “Mario Negri” IRCCS, 20156 Milano, ItalyExperimental Oncology and Biobank Management Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyDepartment of Medicine and Surgery and Translational Medicine, “Sapienza” University of Rome, Radio-Therapy Oncology, Sant′ Andrea Hospital, 00189 Rome, ItalyDipartimento di Scienze Mediche e Chirurgiche Materno-Infantili e dell’Adulto, Università di Modena e Reggio Emilia, 41124 Modena, ItalyHematology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyBackground: In recent years, the scientific community has been paying ever more attention to the promotion of lifestyles aimed at the prevention of late toxicities related to anti-cancer treatments. Methods: Fondazione Italiana Linfomi (FIL) researchers conducted a systematic review in order to evaluate the evidence in favor of the promotion of lifestyles aimed at the prevention of the main sequelae of long-term classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL) in survivors treated at adulthood with first-line or second-line therapy, including autologous stem cell transplants (ASCTs). Pubmed, Embase and Cochrane Library were searched up to December 2020. Results: Seven studies were ultimately included in this systematic review; some of them were eligible for multiple PICOS. The majority of the studies emerged from data extraction regarding cHL; less evidence resulted for DLBCL survivors. Five studies in favor of physical activity provided consistent data for a reduction of the cardiovascular risk in cHL and also in survivors who underwent ASCT. A beneficial effect of physical activity in reducing chronic fatigue was found. Being overweight was associated with a higher risk of coronary heart disease in cHL survivors in one of the two eligible studies. Studies aiming to evaluate the impact of the Mediterranean diet on late toxicities and secondary cancers were lacking. Tailored survivorship care plans (SCP) seemed to represent an optimal tool to guide the follow-up and promote healthier lifestyles in the one eligible study. Thus, promotion of healthy lifestyles and empowering of lymphoma survivors should be implemented through structured models. The study also brought to light numerous areas of future clinical research.https://www.mdpi.com/2072-6694/13/13/3135survivorsclassical Hodgkin lymphomadiffuse large B-cell lymphomahealthy lifestylephysical exercisesurvivorship care plan |
| spellingShingle | Carla Minoia Chiara Gerardi Eleonora Allocati Antonella Daniele Vitaliana De Sanctis Alessia Bari Attilio Guarini The Impact of Healthy Lifestyles on Late Sequelae in Classical Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma Survivors. A Systematic Review by the Fondazione Italiana Linfomi Cancers survivors classical Hodgkin lymphoma diffuse large B-cell lymphoma healthy lifestyle physical exercise survivorship care plan |
| title | The Impact of Healthy Lifestyles on Late Sequelae in Classical Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma Survivors. A Systematic Review by the Fondazione Italiana Linfomi |
| title_full | The Impact of Healthy Lifestyles on Late Sequelae in Classical Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma Survivors. A Systematic Review by the Fondazione Italiana Linfomi |
| title_fullStr | The Impact of Healthy Lifestyles on Late Sequelae in Classical Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma Survivors. A Systematic Review by the Fondazione Italiana Linfomi |
| title_full_unstemmed | The Impact of Healthy Lifestyles on Late Sequelae in Classical Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma Survivors. A Systematic Review by the Fondazione Italiana Linfomi |
| title_short | The Impact of Healthy Lifestyles on Late Sequelae in Classical Hodgkin Lymphoma and Diffuse Large B-Cell Lymphoma Survivors. A Systematic Review by the Fondazione Italiana Linfomi |
| title_sort | impact of healthy lifestyles on late sequelae in classical hodgkin lymphoma and diffuse large b cell lymphoma survivors a systematic review by the fondazione italiana linfomi |
| topic | survivors classical Hodgkin lymphoma diffuse large B-cell lymphoma healthy lifestyle physical exercise survivorship care plan |
| url | https://www.mdpi.com/2072-6694/13/13/3135 |
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