A type 6 secretion system (T6SS) encoded gene within Salmonella enterica serovar Enteritidis contributes to virulence
Bacteria interact with their host through protein secretion systems and surface structures. Pathogenic bacteria encode protein secretion systems that promote the invasion of the host's tissue, the evasion of the host's immune response, the thwarting microbial competitors, and ultimately su...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-12-01
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| Series: | Virulence |
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| Online Access: | http://dx.doi.org/10.1080/21505594.2017.1421829 |
| _version_ | 1828838207428493312 |
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| author | Bryan Troxell |
| author_facet | Bryan Troxell |
| author_sort | Bryan Troxell |
| collection | DOAJ |
| description | Bacteria interact with their host through protein secretion systems and surface structures. Pathogenic bacteria encode protein secretion systems that promote the invasion of the host's tissue, the evasion of the host's immune response, the thwarting microbial competitors, and ultimately survival within the host. For motile bacteria, the presence of extracellular flagella provides the host with a structural motif used for activation of the immune system. Within this issue of Virulence, the article “Identification of a novel gene in ROD9 island of Salmonella Enteritidis involved in the alteration of virulence-associated protein expression” describes the contribution of a gene, SEN1005, toward host-pathogen interaction. The authors demonstrate the contribution of SEN1005 to cell culture bioassays and infection in a mouse model of colitis. In each tested scenario, deletion of SEN1005 results in a phenotypic defect that was complemented by providing the SEN1005 gene in trans. SEN1005 contributes to the expression of known virulence factors within SPI-1, flagellar and chemotaxis genes, and heat shock/chaperone genes. Although much work is needed to fully elucidate the function of SEN1005, this work contributes toward our understanding of the genetic factors used by Salmonella to cause foodborne illnesses. |
| first_indexed | 2024-12-12T18:57:45Z |
| format | Article |
| id | doaj.art-7de44443bf98481d8207bc9aec298fe7 |
| institution | Directory Open Access Journal |
| issn | 2150-5594 2150-5608 |
| language | English |
| last_indexed | 2024-12-12T18:57:45Z |
| publishDate | 2018-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj.art-7de44443bf98481d8207bc9aec298fe72022-12-22T00:15:12ZengTaylor & Francis GroupVirulence2150-55942150-56082018-12-019158558710.1080/21505594.2017.14218291421829A type 6 secretion system (T6SS) encoded gene within Salmonella enterica serovar Enteritidis contributes to virulenceBryan Troxell0Alcami Corporation, Biotechnology departmentBacteria interact with their host through protein secretion systems and surface structures. Pathogenic bacteria encode protein secretion systems that promote the invasion of the host's tissue, the evasion of the host's immune response, the thwarting microbial competitors, and ultimately survival within the host. For motile bacteria, the presence of extracellular flagella provides the host with a structural motif used for activation of the immune system. Within this issue of Virulence, the article “Identification of a novel gene in ROD9 island of Salmonella Enteritidis involved in the alteration of virulence-associated protein expression” describes the contribution of a gene, SEN1005, toward host-pathogen interaction. The authors demonstrate the contribution of SEN1005 to cell culture bioassays and infection in a mouse model of colitis. In each tested scenario, deletion of SEN1005 results in a phenotypic defect that was complemented by providing the SEN1005 gene in trans. SEN1005 contributes to the expression of known virulence factors within SPI-1, flagellar and chemotaxis genes, and heat shock/chaperone genes. Although much work is needed to fully elucidate the function of SEN1005, this work contributes toward our understanding of the genetic factors used by Salmonella to cause foodborne illnesses.http://dx.doi.org/10.1080/21505594.2017.1421829Salmonellainvasionmotilityprotein secretiongene regulation |
| spellingShingle | Bryan Troxell A type 6 secretion system (T6SS) encoded gene within Salmonella enterica serovar Enteritidis contributes to virulence Virulence Salmonella invasion motility protein secretion gene regulation |
| title | A type 6 secretion system (T6SS) encoded gene within Salmonella enterica serovar Enteritidis contributes to virulence |
| title_full | A type 6 secretion system (T6SS) encoded gene within Salmonella enterica serovar Enteritidis contributes to virulence |
| title_fullStr | A type 6 secretion system (T6SS) encoded gene within Salmonella enterica serovar Enteritidis contributes to virulence |
| title_full_unstemmed | A type 6 secretion system (T6SS) encoded gene within Salmonella enterica serovar Enteritidis contributes to virulence |
| title_short | A type 6 secretion system (T6SS) encoded gene within Salmonella enterica serovar Enteritidis contributes to virulence |
| title_sort | type 6 secretion system t6ss encoded gene within salmonella enterica serovar enteritidis contributes to virulence |
| topic | Salmonella invasion motility protein secretion gene regulation |
| url | http://dx.doi.org/10.1080/21505594.2017.1421829 |
| work_keys_str_mv | AT bryantroxell atype6secretionsystemt6ssencodedgenewithinsalmonellaentericaserovarenteritidiscontributestovirulence AT bryantroxell type6secretionsystemt6ssencodedgenewithinsalmonellaentericaserovarenteritidiscontributestovirulence |