Тhe value of transbronchial needle aspiration cytology in the diagnosis of stage I and II sarcoidosis
Background/Aim. Sarcoidosis is a multisystem infmammatory disease of unknown etiology, with the lungs and intrathoracic lymph nodes the most commonly involved. The aim of this study was to assess the contribution of conventional transbronchial needle aspiration (TBNA) cytology in the dia...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2017-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2017/0042-84501600080T.pdf |
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| author | Tatomirović Željka Škuletić Vesna Peković Dragana Karličić Vukoica Đurović Branka Ristić Saša Tomić Ljiljana Džambas Jelena Cerović Snežana |
| author_facet | Tatomirović Željka Škuletić Vesna Peković Dragana Karličić Vukoica Đurović Branka Ristić Saša Tomić Ljiljana Džambas Jelena Cerović Snežana |
| author_sort | Tatomirović Željka |
| collection | DOAJ |
| description | Background/Aim. Sarcoidosis is a multisystem infmammatory disease of unknown
etiology, with the lungs and intrathoracic lymph nodes the most commonly
involved. The aim of this study was to assess the contribution of
conventional transbronchial needle aspiration (TBNA) cytology in the
diagnosis of sarcoidosis presenting as mediastinal/hilar lymphadenopathy.
Methods. In this retrospective study, 58 patients with suspicion of stage I
and II sarcoidosis underwent first flexibile, and then, a rigid bronhoscopy,
during which TBNA of mediastinal or hilar lumph node with a 19 gauge (G)
needle was done. Material from the needle was put on glass slide and prepared
for the cytological and histopathological examination. Results. Out of 58
patients submitted to TBNA of mediastinal or hilar lymph nodes, adequate
material for cytological diagnostics was obtained in 53 (91.37%). Out of 53
adequate cytological samples, in 38 (71.69%) noncaseous granulomatous
inflammation (NGI) was found, while in corresponding histopathological
samples, NGI was found in 48 (90.56%), which was significantly higher (p <
0.05). Of cytological smears, out of the cell types typical for granulomatous
inflammation, in 26 (63.15%) patients the clusters of the epitheloid cells
were found, in 8 (21.05%) there were both, clusters of epitheloid cells and
giant multinuclear hystiocytes, and in 6 (15.76%) only single scattered
epitheloid cells or small clusters of several epitheloid cells were found.
The sensitivity of TBNA cytology in our group of patients with sarcoidosis
was 76%, specificity 100% and accuracy 77.34%. Conclusion. TBNA is an
efficient and safe procedure in the diagnosis of sarcoidosis, minimally
invasive and with a little risk of complications. Using 19 G needle enables
obtaining material for histological and cytological analyses, as well which
contribute to the sensitivity of diagnosting sarcoidosis. The value of this
type of diagnostics depends on qualification and experience both of
bronchoscopist and cytologist/pathologist, as well, of the interpreter of
such a material. |
| first_indexed | 2024-12-11T21:29:21Z |
| format | Article |
| id | doaj.art-7de44c6857b04379aa7f0bd9709b42b5 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 2406-0720 |
| language | English |
| last_indexed | 2024-12-11T21:29:21Z |
| publishDate | 2017-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-7de44c6857b04379aa7f0bd9709b42b52022-12-22T00:50:12ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502406-07202017-01-0174653654210.2298/VSP151105080T0042-84501600080TТhe value of transbronchial needle aspiration cytology in the diagnosis of stage I and II sarcoidosisTatomirović Željka0Škuletić Vesna1Peković Dragana2Karličić Vukoica3Đurović Branka4Ristić Saša5Tomić Ljiljana6Džambas Jelena7Cerović Snežana8Military Medical Academy, Institute for Pathology and Forensic Medicine, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, BelgradeMilitary Medical Academy, Institute for Pathology and Forensic Medicine, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, BelgradeUniversity of Defence, Faculty of Medicine of the Military Medical Academy, BelgradeMilitary Medical Academy, Clinic for Pulmonary Disease, BelgradeUniversity of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade + Military Medical Academy, Institute for Occupational Medicine, BelgradeMilitary Medical Academy, Institute for Pathology and Forensic Medicine, BelgradeMilitary Medical Academy, Institute for Pathology and Forensic Medicine, BelgradeMilitary Medical Academy, Institute for Pathology and Forensic Medicine, BelgradeMilitary Medical Academy, Institute for Pathology and Forensic Medicine, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, BelgradeBackground/Aim. Sarcoidosis is a multisystem infmammatory disease of unknown etiology, with the lungs and intrathoracic lymph nodes the most commonly involved. The aim of this study was to assess the contribution of conventional transbronchial needle aspiration (TBNA) cytology in the diagnosis of sarcoidosis presenting as mediastinal/hilar lymphadenopathy. Methods. In this retrospective study, 58 patients with suspicion of stage I and II sarcoidosis underwent first flexibile, and then, a rigid bronhoscopy, during which TBNA of mediastinal or hilar lumph node with a 19 gauge (G) needle was done. Material from the needle was put on glass slide and prepared for the cytological and histopathological examination. Results. Out of 58 patients submitted to TBNA of mediastinal or hilar lymph nodes, adequate material for cytological diagnostics was obtained in 53 (91.37%). Out of 53 adequate cytological samples, in 38 (71.69%) noncaseous granulomatous inflammation (NGI) was found, while in corresponding histopathological samples, NGI was found in 48 (90.56%), which was significantly higher (p < 0.05). Of cytological smears, out of the cell types typical for granulomatous inflammation, in 26 (63.15%) patients the clusters of the epitheloid cells were found, in 8 (21.05%) there were both, clusters of epitheloid cells and giant multinuclear hystiocytes, and in 6 (15.76%) only single scattered epitheloid cells or small clusters of several epitheloid cells were found. The sensitivity of TBNA cytology in our group of patients with sarcoidosis was 76%, specificity 100% and accuracy 77.34%. Conclusion. TBNA is an efficient and safe procedure in the diagnosis of sarcoidosis, minimally invasive and with a little risk of complications. Using 19 G needle enables obtaining material for histological and cytological analyses, as well which contribute to the sensitivity of diagnosting sarcoidosis. The value of this type of diagnostics depends on qualification and experience both of bronchoscopist and cytologist/pathologist, as well, of the interpreter of such a material.http://www.doiserbia.nb.rs/img/doi/0042-8450/2017/0042-84501600080T.pdfsarcoidosisdiagnosisdiagnosis, differentiallymphnodesmediastinumbiopsy, fine-needlesensitivity and specirficity |
| spellingShingle | Tatomirović Željka Škuletić Vesna Peković Dragana Karličić Vukoica Đurović Branka Ristić Saša Tomić Ljiljana Džambas Jelena Cerović Snežana Тhe value of transbronchial needle aspiration cytology in the diagnosis of stage I and II sarcoidosis Vojnosanitetski Pregled sarcoidosis diagnosis diagnosis, differential lymphnodes mediastinum biopsy, fine-needle sensitivity and specirficity |
| title | Тhe value of transbronchial needle aspiration cytology in the diagnosis of stage I and II sarcoidosis |
| title_full | Тhe value of transbronchial needle aspiration cytology in the diagnosis of stage I and II sarcoidosis |
| title_fullStr | Тhe value of transbronchial needle aspiration cytology in the diagnosis of stage I and II sarcoidosis |
| title_full_unstemmed | Тhe value of transbronchial needle aspiration cytology in the diagnosis of stage I and II sarcoidosis |
| title_short | Тhe value of transbronchial needle aspiration cytology in the diagnosis of stage I and II sarcoidosis |
| title_sort | тhe value of transbronchial needle aspiration cytology in the diagnosis of stage i and ii sarcoidosis |
| topic | sarcoidosis diagnosis diagnosis, differential lymphnodes mediastinum biopsy, fine-needle sensitivity and specirficity |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2017/0042-84501600080T.pdf |
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