Potential contrasting effects of platelets on the migration and invasion of sarcomas versus carcinomas
The ability of platelets to promote carcinoma and melanoma progression has been thoroughly studied and occurs in numerous ways. In contrast, the effect of platelets on sarcomas, tumors arising from mesenchymal cells, has received very little attention. This study was undertaken to simultaneously com...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-07-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2020.1792433 |
| _version_ | 1797684145685528576 |
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| author | Jinsoo Yoon Christopher R. Parish Anneke C. Blackburn Lucy A. Coupland |
| author_facet | Jinsoo Yoon Christopher R. Parish Anneke C. Blackburn Lucy A. Coupland |
| author_sort | Jinsoo Yoon |
| collection | DOAJ |
| description | The ability of platelets to promote carcinoma and melanoma progression has been thoroughly studied and occurs in numerous ways. In contrast, the effect of platelets on sarcomas, tumors arising from mesenchymal cells, has received very little attention. This study was undertaken to simultaneously compare the effects of platelets on murine and human sarcomas and carcinomas. In contrast to their effect on carcinomas, platelets inhibited the invasion of some murine- and all human sarcomas tested in vitro. Further invasion studies with TGFβ treatment only partially recapitulated the results seen with whole platelets. In a spontaneous tumor growth and lung metastasis model, platelets promoted 4T1 mammary carcinoma metastasis but not MCA-1 fibrosarcoma metastasis. Gene expression analysis of the platelet-promoted MDA-MB-231 breast carcinoma, and the platelet-inhibited HT1080 fibrosarcoma cell lines revealed that exposure of MDA-MB-231 to platelets, resulted in upregulation of oncogenes and EMT-associated genes whereas in HT1080 a tumor-suppressor gene was significantly upregulated. Thus, this study has revealed a potential diametrically opposing effect of platelets on mesenchymal and epithelial cancers, a finding that warrants further investigation. |
| first_indexed | 2024-03-12T00:26:19Z |
| format | Article |
| id | doaj.art-7de76586a59641d38724f375ebd59f66 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:26:19Z |
| publishDate | 2021-07-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-7de76586a59641d38724f375ebd59f662023-09-15T10:38:08ZengTaylor & Francis GroupPlatelets0953-71041369-16352021-07-0132566267010.1080/09537104.2020.17924331792433Potential contrasting effects of platelets on the migration and invasion of sarcomas versus carcinomasJinsoo Yoon0Christopher R. Parish1Anneke C. Blackburn2Lucy A. Coupland3The John Curtin School of Medical Research, the Australian National UniversityThe John Curtin School of Medical Research, the Australian National UniversityThe John Curtin School of Medical Research, the Australian National UniversityThe John Curtin School of Medical Research, the Australian National UniversityThe ability of platelets to promote carcinoma and melanoma progression has been thoroughly studied and occurs in numerous ways. In contrast, the effect of platelets on sarcomas, tumors arising from mesenchymal cells, has received very little attention. This study was undertaken to simultaneously compare the effects of platelets on murine and human sarcomas and carcinomas. In contrast to their effect on carcinomas, platelets inhibited the invasion of some murine- and all human sarcomas tested in vitro. Further invasion studies with TGFβ treatment only partially recapitulated the results seen with whole platelets. In a spontaneous tumor growth and lung metastasis model, platelets promoted 4T1 mammary carcinoma metastasis but not MCA-1 fibrosarcoma metastasis. Gene expression analysis of the platelet-promoted MDA-MB-231 breast carcinoma, and the platelet-inhibited HT1080 fibrosarcoma cell lines revealed that exposure of MDA-MB-231 to platelets, resulted in upregulation of oncogenes and EMT-associated genes whereas in HT1080 a tumor-suppressor gene was significantly upregulated. Thus, this study has revealed a potential diametrically opposing effect of platelets on mesenchymal and epithelial cancers, a finding that warrants further investigation.http://dx.doi.org/10.1080/09537104.2020.1792433carcinomasinvasionmigrationplateletssarcomas |
| spellingShingle | Jinsoo Yoon Christopher R. Parish Anneke C. Blackburn Lucy A. Coupland Potential contrasting effects of platelets on the migration and invasion of sarcomas versus carcinomas Platelets carcinomas invasion migration platelets sarcomas |
| title | Potential contrasting effects of platelets on the migration and invasion of sarcomas versus carcinomas |
| title_full | Potential contrasting effects of platelets on the migration and invasion of sarcomas versus carcinomas |
| title_fullStr | Potential contrasting effects of platelets on the migration and invasion of sarcomas versus carcinomas |
| title_full_unstemmed | Potential contrasting effects of platelets on the migration and invasion of sarcomas versus carcinomas |
| title_short | Potential contrasting effects of platelets on the migration and invasion of sarcomas versus carcinomas |
| title_sort | potential contrasting effects of platelets on the migration and invasion of sarcomas versus carcinomas |
| topic | carcinomas invasion migration platelets sarcomas |
| url | http://dx.doi.org/10.1080/09537104.2020.1792433 |
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