Bradycardic and Antiarrhythmic Effects of the D-Limonene in Rats
Abstract Background: D-limonene (DL) is a monoterpene and is the major component in the essential oil of citrus fruit. It presents antihyperglycemic and vasodilatation activities. Objectives: This study evaluated the cardiovascular effects and potential antiarrhythmic of DL in rats. Methods: Hemo...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Cardiologia (SBC)
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| Series: | Arquivos Brasileiros de Cardiologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019005016103&lng=en&tlng=en |
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| author | Gildenisson Araújo do Nascimento Diego Santos de Souza Bruno Santos Lima Carla Maria Lins de Vasconcelos Adriano Antunes de Souza Araújo Aimée Obolari Durço Lucindo José Quintans-Junior Jackson Roberto Guedes da Silva Almeida Aldeída Pereira Oliveira Valter Joviniano de Santana-Filho André Sales Barreto Márcio Roberto Viana dos Santos |
| author_facet | Gildenisson Araújo do Nascimento Diego Santos de Souza Bruno Santos Lima Carla Maria Lins de Vasconcelos Adriano Antunes de Souza Araújo Aimée Obolari Durço Lucindo José Quintans-Junior Jackson Roberto Guedes da Silva Almeida Aldeída Pereira Oliveira Valter Joviniano de Santana-Filho André Sales Barreto Márcio Roberto Viana dos Santos |
| author_sort | Gildenisson Araújo do Nascimento |
| collection | DOAJ |
| description | Abstract Background: D-limonene (DL) is a monoterpene and is the major component in the essential oil of citrus fruit. It presents antihyperglycemic and vasodilatation activities. Objectives: This study evaluated the cardiovascular effects and potential antiarrhythmic of DL in rats. Methods: Hemodynamic and electrocardiographic (ECG) parameters were measured in male Wistar rats, which under anesthesia had been cannulated in the abdominal aorta and lower vena cava and had electrodes subcutaneously implanted. In the in vitro approach, the heart was removed and perfused using the Langendorff technique. The significance level adopted was 5% (p < 0.05). Results: DL, in doses of 10, 20, and 40 mg/kg (i.v), produced intense and persistent bradycardia associated with hypotension. Bradycardia with prolonged QTc was observed in the ECG in vivo recording. In the in vivo model of arrhythmia induced by Bay K8644, DL (10 mg/kg) decreased the arrhythmia score from 15.33 ± 3.52 to 4.0 ± 2.64 u.a (p < 0.05, n = 4). In isolated perfused hearts, DL (10-3 M) promoted significant reductions in heart rate (from 228.6 ± 8.5 ms to 196.0 ± 9.3 bpm; p < 0.05) and left ventricular development pressure (from 25.2 ± 3.4 to 5.9 ± 1.8 mmHg; n = 5, p < 0.05). Conclusions: DL produces bradycardia and antiarrhythmic activity in rat heart. |
| first_indexed | 2024-04-12T05:16:05Z |
| format | Article |
| id | doaj.art-7de95adcfe0640b5af4cba6b6d4804f4 |
| institution | Directory Open Access Journal |
| issn | 1678-4170 |
| language | English |
| last_indexed | 2024-04-12T05:16:05Z |
| publisher | Sociedade Brasileira de Cardiologia (SBC) |
| record_format | Article |
| series | Arquivos Brasileiros de Cardiologia |
| spelling | doaj.art-7de95adcfe0640b5af4cba6b6d4804f42022-12-22T03:46:37ZengSociedade Brasileira de Cardiologia (SBC)Arquivos Brasileiros de Cardiologia1678-417010.5935/abc.20190173S0066-782X2019005016103Bradycardic and Antiarrhythmic Effects of the D-Limonene in RatsGildenisson Araújo do NascimentoDiego Santos de SouzaBruno Santos LimaCarla Maria Lins de VasconcelosAdriano Antunes de Souza AraújoAimée Obolari DurçoLucindo José Quintans-JuniorJackson Roberto Guedes da Silva AlmeidaAldeída Pereira OliveiraValter Joviniano de Santana-FilhoAndré Sales BarretoMárcio Roberto Viana dos SantosAbstract Background: D-limonene (DL) is a monoterpene and is the major component in the essential oil of citrus fruit. It presents antihyperglycemic and vasodilatation activities. Objectives: This study evaluated the cardiovascular effects and potential antiarrhythmic of DL in rats. Methods: Hemodynamic and electrocardiographic (ECG) parameters were measured in male Wistar rats, which under anesthesia had been cannulated in the abdominal aorta and lower vena cava and had electrodes subcutaneously implanted. In the in vitro approach, the heart was removed and perfused using the Langendorff technique. The significance level adopted was 5% (p < 0.05). Results: DL, in doses of 10, 20, and 40 mg/kg (i.v), produced intense and persistent bradycardia associated with hypotension. Bradycardia with prolonged QTc was observed in the ECG in vivo recording. In the in vivo model of arrhythmia induced by Bay K8644, DL (10 mg/kg) decreased the arrhythmia score from 15.33 ± 3.52 to 4.0 ± 2.64 u.a (p < 0.05, n = 4). In isolated perfused hearts, DL (10-3 M) promoted significant reductions in heart rate (from 228.6 ± 8.5 ms to 196.0 ± 9.3 bpm; p < 0.05) and left ventricular development pressure (from 25.2 ± 3.4 to 5.9 ± 1.8 mmHg; n = 5, p < 0.05). Conclusions: DL produces bradycardia and antiarrhythmic activity in rat heart.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019005016103&lng=en&tlng=enRatosLimonenoMonoterpenosArritmias CardíacasAntiarrítmicosBradicardiaAntioxidantes |
| spellingShingle | Gildenisson Araújo do Nascimento Diego Santos de Souza Bruno Santos Lima Carla Maria Lins de Vasconcelos Adriano Antunes de Souza Araújo Aimée Obolari Durço Lucindo José Quintans-Junior Jackson Roberto Guedes da Silva Almeida Aldeída Pereira Oliveira Valter Joviniano de Santana-Filho André Sales Barreto Márcio Roberto Viana dos Santos Bradycardic and Antiarrhythmic Effects of the D-Limonene in Rats Arquivos Brasileiros de Cardiologia Ratos Limoneno Monoterpenos Arritmias Cardíacas Antiarrítmicos Bradicardia Antioxidantes |
| title | Bradycardic and Antiarrhythmic Effects of the D-Limonene in Rats |
| title_full | Bradycardic and Antiarrhythmic Effects of the D-Limonene in Rats |
| title_fullStr | Bradycardic and Antiarrhythmic Effects of the D-Limonene in Rats |
| title_full_unstemmed | Bradycardic and Antiarrhythmic Effects of the D-Limonene in Rats |
| title_short | Bradycardic and Antiarrhythmic Effects of the D-Limonene in Rats |
| title_sort | bradycardic and antiarrhythmic effects of the d limonene in rats |
| topic | Ratos Limoneno Monoterpenos Arritmias Cardíacas Antiarrítmicos Bradicardia Antioxidantes |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2019005016103&lng=en&tlng=en |
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