Myeloid Cells during Viral Infections and Inflammation
Myeloid cells represent a diverse range of innate leukocytes that are crucial for mounting successful immune responses against viruses. These cells are responsible for detecting pathogen-associated molecular patterns, thereby initiating a signaling cascade that results in the production of cytokines...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-02-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/11/2/168 |
| _version_ | 1811290904218042368 |
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| author | Ashley A. Stegelmeier Jacob P. van Vloten Robert C. Mould Elaine M. Klafuric Jessica A. Minott Sarah K. Wootton Byram W. Bridle Khalil Karimi |
| author_facet | Ashley A. Stegelmeier Jacob P. van Vloten Robert C. Mould Elaine M. Klafuric Jessica A. Minott Sarah K. Wootton Byram W. Bridle Khalil Karimi |
| author_sort | Ashley A. Stegelmeier |
| collection | DOAJ |
| description | Myeloid cells represent a diverse range of innate leukocytes that are crucial for mounting successful immune responses against viruses. These cells are responsible for detecting pathogen-associated molecular patterns, thereby initiating a signaling cascade that results in the production of cytokines such as interferons to mitigate infections. The aim of this review is to outline recent advances in our knowledge of the roles that neutrophils and inflammatory monocytes play in initiating and coordinating host responses against viral infections. A focus is placed on myeloid cell development, trafficking and antiviral mechanisms. Although known for promoting inflammation, there is a growing body of literature which demonstrates that myeloid cells can also play critical regulatory or immunosuppressive roles, especially following the elimination of viruses. Additionally, the ability of myeloid cells to control other innate and adaptive leukocytes during viral infections situates these cells as key, yet under-appreciated mediators of pathogenic inflammation that can sometimes trigger cytokine storms. The information presented here should assist researchers in integrating myeloid cell biology into the design of novel and more effective virus-targeted therapies. |
| first_indexed | 2024-04-13T04:20:27Z |
| format | Article |
| id | doaj.art-7deba92fcd1a4fb28a1fb17e052e5fdb |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-13T04:20:27Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-7deba92fcd1a4fb28a1fb17e052e5fdb2022-12-22T03:02:47ZengMDPI AGViruses1999-49152019-02-0111216810.3390/v11020168v11020168Myeloid Cells during Viral Infections and InflammationAshley A. Stegelmeier0Jacob P. van Vloten1Robert C. Mould2Elaine M. Klafuric3Jessica A. Minott4Sarah K. Wootton5Byram W. Bridle6Khalil Karimi7Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, CanadaDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, CanadaMyeloid cells represent a diverse range of innate leukocytes that are crucial for mounting successful immune responses against viruses. These cells are responsible for detecting pathogen-associated molecular patterns, thereby initiating a signaling cascade that results in the production of cytokines such as interferons to mitigate infections. The aim of this review is to outline recent advances in our knowledge of the roles that neutrophils and inflammatory monocytes play in initiating and coordinating host responses against viral infections. A focus is placed on myeloid cell development, trafficking and antiviral mechanisms. Although known for promoting inflammation, there is a growing body of literature which demonstrates that myeloid cells can also play critical regulatory or immunosuppressive roles, especially following the elimination of viruses. Additionally, the ability of myeloid cells to control other innate and adaptive leukocytes during viral infections situates these cells as key, yet under-appreciated mediators of pathogenic inflammation that can sometimes trigger cytokine storms. The information presented here should assist researchers in integrating myeloid cell biology into the design of novel and more effective virus-targeted therapies.https://www.mdpi.com/1999-4915/11/2/168neutrophilsinflammatory monocytesinflammationviral infectionmyeloid cellstype I interferon |
| spellingShingle | Ashley A. Stegelmeier Jacob P. van Vloten Robert C. Mould Elaine M. Klafuric Jessica A. Minott Sarah K. Wootton Byram W. Bridle Khalil Karimi Myeloid Cells during Viral Infections and Inflammation Viruses neutrophils inflammatory monocytes inflammation viral infection myeloid cells type I interferon |
| title | Myeloid Cells during Viral Infections and Inflammation |
| title_full | Myeloid Cells during Viral Infections and Inflammation |
| title_fullStr | Myeloid Cells during Viral Infections and Inflammation |
| title_full_unstemmed | Myeloid Cells during Viral Infections and Inflammation |
| title_short | Myeloid Cells during Viral Infections and Inflammation |
| title_sort | myeloid cells during viral infections and inflammation |
| topic | neutrophils inflammatory monocytes inflammation viral infection myeloid cells type I interferon |
| url | https://www.mdpi.com/1999-4915/11/2/168 |
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