REGULATION OF IBUPROFEN RELEASE RATE FROM MATRIX TABLETS
Release profiles were investigated from tablets of ibuprofen in media simulating the conditions of the gastrointestinal tract. Carbopol Ultrez 21 was used as prolongator polymer. The formulations with three different neutralizing agents [L-lysine, N-methylglucosamine (MGA), sodium hydrocarbonate] in...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/314 |
| _version_ | 1797875043956424704 |
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| author | N. I. Filippova V. A. Vainshtein A. V. Son S. A. Minina |
| author_facet | N. I. Filippova V. A. Vainshtein A. V. Son S. A. Minina |
| author_sort | N. I. Filippova |
| collection | DOAJ |
| description | Release profiles were investigated from tablets of ibuprofen in media simulating the conditions of the gastrointestinal tract. Carbopol Ultrez 21 was used as prolongator polymer. The formulations with three different neutralizing agents [L-lysine, N-methylglucosamine (MGA), sodium hydrocarbonate] in several carbopol : neutralizer ratios were tabletted with using the wet granulation method. Faster release of ibuprofen has been observed in formulations with sodium hydrocarbonate, than in formulations with amine containing L-lysine and MGA. Both the amount and neutralization rate of carbopol influence significantly on rate and extent of ibuprofen release from tablets. Carbopol swelling rate grows up with increasing of neutralizer content in tablet. |
| first_indexed | 2024-04-10T01:40:22Z |
| format | Article |
| id | doaj.art-7decc441b2b244f0ac2f55420d40525f |
| institution | Directory Open Access Journal |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| last_indexed | 2024-04-10T01:40:22Z |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj.art-7decc441b2b244f0ac2f55420d40525f2023-03-13T09:13:58ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-01015864314REGULATION OF IBUPROFEN RELEASE RATE FROM MATRIX TABLETSN. I. Filippova0V. A. Vainshtein1A. V. Son2S. A. Minina3ФГБОУ ВО «Санкт-Петербургская государственная химико-фармацевтическая академия» Министерства здравоохранения Российской ФедерацииФГБОУ ВО «Санкт-Петербургская государственная химико-фармацевтическая академия» Министерства здравоохранения Российской ФедерацииФГБОУ ВО «Санкт-Петербургская государственная химико-фармацевтическая академия» Министерства здравоохранения Российской ФедерацииФГБОУ ВО «Санкт-Петербургская государственная химико-фармацевтическая академия» Министерства здравоохранения Российской ФедерацииRelease profiles were investigated from tablets of ibuprofen in media simulating the conditions of the gastrointestinal tract. Carbopol Ultrez 21 was used as prolongator polymer. The formulations with three different neutralizing agents [L-lysine, N-methylglucosamine (MGA), sodium hydrocarbonate] in several carbopol : neutralizer ratios were tabletted with using the wet granulation method. Faster release of ibuprofen has been observed in formulations with sodium hydrocarbonate, than in formulations with amine containing L-lysine and MGA. Both the amount and neutralization rate of carbopol influence significantly on rate and extent of ibuprofen release from tablets. Carbopol swelling rate grows up with increasing of neutralizer content in tablet.https://www.pharmjournal.ru/jour/article/view/314матричные таблеткизамедленное высвобождениеибупрофенкарбополl-лизинn-метилглюкозамин |
| spellingShingle | N. I. Filippova V. A. Vainshtein A. V. Son S. A. Minina REGULATION OF IBUPROFEN RELEASE RATE FROM MATRIX TABLETS Разработка и регистрация лекарственных средств матричные таблетки замедленное высвобождение ибупрофен карбопол l-лизин n-метилглюкозамин |
| title | REGULATION OF IBUPROFEN RELEASE RATE FROM MATRIX TABLETS |
| title_full | REGULATION OF IBUPROFEN RELEASE RATE FROM MATRIX TABLETS |
| title_fullStr | REGULATION OF IBUPROFEN RELEASE RATE FROM MATRIX TABLETS |
| title_full_unstemmed | REGULATION OF IBUPROFEN RELEASE RATE FROM MATRIX TABLETS |
| title_short | REGULATION OF IBUPROFEN RELEASE RATE FROM MATRIX TABLETS |
| title_sort | regulation of ibuprofen release rate from matrix tablets |
| topic | матричные таблетки замедленное высвобождение ибупрофен карбопол l-лизин n-метилглюкозамин |
| url | https://www.pharmjournal.ru/jour/article/view/314 |
| work_keys_str_mv | AT nifilippova regulationofibuprofenreleaseratefrommatrixtablets AT vavainshtein regulationofibuprofenreleaseratefrommatrixtablets AT avson regulationofibuprofenreleaseratefrommatrixtablets AT saminina regulationofibuprofenreleaseratefrommatrixtablets |