New Measles Genotype, Uganda
We report the first genetic characterization of wildtype measles viruses from Uganda. Thirty-six virus isolates from outbreaks in 6 districts were analyzed from 2000 to 2002. Analyses of sequences of the nucleoprotein (N) and hemagglutinin (H) genes showed that the Ugandan isolates were all closely...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2005-10-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/11/10/05-0431_article |
| _version_ | 1818416867152232448 |
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| author | Apollo Muwonge Miriam Nanyunja Paul A. Rota Josephine Bwogi Luis Lowe Stephanie L. Liffick William J. Bellini Sempala Sylvester |
| author_facet | Apollo Muwonge Miriam Nanyunja Paul A. Rota Josephine Bwogi Luis Lowe Stephanie L. Liffick William J. Bellini Sempala Sylvester |
| author_sort | Apollo Muwonge |
| collection | DOAJ |
| description | We report the first genetic characterization of wildtype measles viruses from Uganda. Thirty-six virus isolates from outbreaks in 6 districts were analyzed from 2000 to 2002. Analyses of sequences of the nucleoprotein (N) and hemagglutinin (H) genes showed that the Ugandan isolates were all closely related, and phylogenetic analysis indicated that these viruses were members of a unique group within clade D. Sequences of the Ugandan viruses were not closely related to any of the World Health Organization reference sequences representing the 22 currently recognized genotypes. The minimum nucleotide divergence between the Ugandan viruses and the most closely related reference strain, genotype D2, was 3.1% for the N gene and 2.6% for the H gene. Therefore, Ugandan viruses should be considered a new, proposed genotype (d10). This new sequence information will expand the utility of molecular epidemiologic techniques for describing measles transmission patterns in eastern Africa. |
| first_indexed | 2024-12-14T11:57:42Z |
| format | Article |
| id | doaj.art-7decf747b53b461fa360a0b23a9641f7 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-14T11:57:42Z |
| publishDate | 2005-10-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-7decf747b53b461fa360a0b23a9641f72022-12-21T23:02:04ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592005-10-0111101522152610.3201/eid1110.050431New Measles Genotype, UgandaApollo MuwongeMiriam NanyunjaPaul A. RotaJosephine BwogiLuis LoweStephanie L. LiffickWilliam J. BelliniSempala SylvesterWe report the first genetic characterization of wildtype measles viruses from Uganda. Thirty-six virus isolates from outbreaks in 6 districts were analyzed from 2000 to 2002. Analyses of sequences of the nucleoprotein (N) and hemagglutinin (H) genes showed that the Ugandan isolates were all closely related, and phylogenetic analysis indicated that these viruses were members of a unique group within clade D. Sequences of the Ugandan viruses were not closely related to any of the World Health Organization reference sequences representing the 22 currently recognized genotypes. The minimum nucleotide divergence between the Ugandan viruses and the most closely related reference strain, genotype D2, was 3.1% for the N gene and 2.6% for the H gene. Therefore, Ugandan viruses should be considered a new, proposed genotype (d10). This new sequence information will expand the utility of molecular epidemiologic techniques for describing measles transmission patterns in eastern Africa.https://wwwnc.cdc.gov/eid/article/11/10/05-0431_articleMeaslesvirusisolationsequencinggenotyperesearch |
| spellingShingle | Apollo Muwonge Miriam Nanyunja Paul A. Rota Josephine Bwogi Luis Lowe Stephanie L. Liffick William J. Bellini Sempala Sylvester New Measles Genotype, Uganda Emerging Infectious Diseases Measles virus isolation sequencing genotype research |
| title | New Measles Genotype, Uganda |
| title_full | New Measles Genotype, Uganda |
| title_fullStr | New Measles Genotype, Uganda |
| title_full_unstemmed | New Measles Genotype, Uganda |
| title_short | New Measles Genotype, Uganda |
| title_sort | new measles genotype uganda |
| topic | Measles virus isolation sequencing genotype research |
| url | https://wwwnc.cdc.gov/eid/article/11/10/05-0431_article |
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