Reliability of Rodent and Rabbit Models in Preeclampsia Research
In vivo studies on the pathology of gestation, including preeclampsia, often use small mammals such as rabbits or rodents, i.e., mice, rats, hamsters, and guinea pigs. The key advantage of these animals is their short reproductive cycle; in addition, similar to humans, they also develop a haemochori...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/14344 |
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| author | Agata Sakowicz Michalina Bralewska Piotr Kamola Tadeusz Pietrucha |
| author_facet | Agata Sakowicz Michalina Bralewska Piotr Kamola Tadeusz Pietrucha |
| author_sort | Agata Sakowicz |
| collection | DOAJ |
| description | In vivo studies on the pathology of gestation, including preeclampsia, often use small mammals such as rabbits or rodents, i.e., mice, rats, hamsters, and guinea pigs. The key advantage of these animals is their short reproductive cycle; in addition, similar to humans, they also develop a haemochorial placenta and present a similar transformation of maternal spiral arteries. Interestingly, pregnant dams also demonstrate a similar reaction to inflammatory factors and placentally derived antiangiogenic factors, i.e., soluble fms-like tyrosine kinase 1 (sFlt-1) or soluble endoglin-1 (sEng), as preeclamptic women: all animals present an increase in blood pressure and usually proteinuria. These constitute the classical duet that allows for the recognition of preeclampsia. However, the time of initiation of maternal vessel remodelling and the depth of trophoblast invasion differs between rabbits, rodents, and humans. Unfortunately, at present, no known animal replicates a human pregnancy exactly, and hence, the use of rabbit and rodent models is restricted to the investigation of individual aspects of human gestation only. This article compares the process of placentation in rodents, rabbits, and humans, which should be considered when planning experiments on preeclampsia; these aspects might determine the success, or failure, of the study. The report also reviews the rodent and rabbit models used to investigate certain aspects of the pathomechanism of human preeclampsia, especially those related to incorrect trophoblast invasion, placental hypoxia, inflammation, or maternal endothelial dysfunction. |
| first_indexed | 2024-03-09T18:15:47Z |
| format | Article |
| id | doaj.art-7decf95bbb634964b6d865e9fef818d1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:15:47Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7decf95bbb634964b6d865e9fef818d12023-11-24T08:42:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221434410.3390/ijms232214344Reliability of Rodent and Rabbit Models in Preeclampsia ResearchAgata Sakowicz0Michalina Bralewska1Piotr Kamola2Tadeusz Pietrucha3Department of Medical Biotechnology, Medical University of Lodz, 90-752 Lodz, PolandDepartment of Medical Biotechnology, Medical University of Lodz, 90-752 Lodz, PolandDepartment of Haemostasis and Haemostatic Disorders, Biomedical Sciences, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, PolandDepartment of Medical Biotechnology, Medical University of Lodz, 90-752 Lodz, PolandIn vivo studies on the pathology of gestation, including preeclampsia, often use small mammals such as rabbits or rodents, i.e., mice, rats, hamsters, and guinea pigs. The key advantage of these animals is their short reproductive cycle; in addition, similar to humans, they also develop a haemochorial placenta and present a similar transformation of maternal spiral arteries. Interestingly, pregnant dams also demonstrate a similar reaction to inflammatory factors and placentally derived antiangiogenic factors, i.e., soluble fms-like tyrosine kinase 1 (sFlt-1) or soluble endoglin-1 (sEng), as preeclamptic women: all animals present an increase in blood pressure and usually proteinuria. These constitute the classical duet that allows for the recognition of preeclampsia. However, the time of initiation of maternal vessel remodelling and the depth of trophoblast invasion differs between rabbits, rodents, and humans. Unfortunately, at present, no known animal replicates a human pregnancy exactly, and hence, the use of rabbit and rodent models is restricted to the investigation of individual aspects of human gestation only. This article compares the process of placentation in rodents, rabbits, and humans, which should be considered when planning experiments on preeclampsia; these aspects might determine the success, or failure, of the study. The report also reviews the rodent and rabbit models used to investigate certain aspects of the pathomechanism of human preeclampsia, especially those related to incorrect trophoblast invasion, placental hypoxia, inflammation, or maternal endothelial dysfunction.https://www.mdpi.com/1422-0067/23/22/14344mouseplacentapreeclampsiarabbitratrodents |
| spellingShingle | Agata Sakowicz Michalina Bralewska Piotr Kamola Tadeusz Pietrucha Reliability of Rodent and Rabbit Models in Preeclampsia Research International Journal of Molecular Sciences mouse placenta preeclampsia rabbit rat rodents |
| title | Reliability of Rodent and Rabbit Models in Preeclampsia Research |
| title_full | Reliability of Rodent and Rabbit Models in Preeclampsia Research |
| title_fullStr | Reliability of Rodent and Rabbit Models in Preeclampsia Research |
| title_full_unstemmed | Reliability of Rodent and Rabbit Models in Preeclampsia Research |
| title_short | Reliability of Rodent and Rabbit Models in Preeclampsia Research |
| title_sort | reliability of rodent and rabbit models in preeclampsia research |
| topic | mouse placenta preeclampsia rabbit rat rodents |
| url | https://www.mdpi.com/1422-0067/23/22/14344 |
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