Data on molecular docking of naturally occurring flavonoids with biologically important targets
Flavonoids in nature are known to possess various activities such as anti-inflammatory, antimicrobial, anticancer, antioxidant, neuroprotective, anti-HIV activities etc., The molecular docking was performed by 26 naturally occurring flavonoids with selected targets COX-2, hydroxyacyl-ACP dehydratase...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-04-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352340920301372 |
| _version_ | 1818943071026413568 |
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| author | Anguraj Moulishankar Karthikeyan Lakshmanan |
| author_facet | Anguraj Moulishankar Karthikeyan Lakshmanan |
| author_sort | Anguraj Moulishankar |
| collection | DOAJ |
| description | Flavonoids in nature are known to possess various activities such as anti-inflammatory, antimicrobial, anticancer, antioxidant, neuroprotective, anti-HIV activities etc., The molecular docking was performed by 26 naturally occurring flavonoids with selected targets COX-2, hydroxyacyl-ACP dehydratase, tyrosinase from Agaricus bisporus, isomaltase from Saccharomyces cerevisiae, Human IkB kinase beta, Human ABC transporter, topoisomerase II, topoisomerase IV, N-myristoyltransferase from Candida albicans, Peptide deformylase from Pseudomonas aeruginosa, polypeptide deformylase from Streptococcus pneumoniae. The analysis was based on docking score, glide energy, interactions type (bond type and distance) and interaction with amino acids. The top 5 flavonoids with best docking score was reported. The in-silico results provided for 26 naturally occurring flavonoid shows that they reduce the risk of inflammation, cancer and infectious disease if people have taken in diet continuously. The provided docking data of flavonoids may be useful to synthesis novel drug candidate for the mentioned targets. Keywords: Molecular docking, Flavonoids, Antimicrobial, Anti-cancer, Anti-inflammatory, Glide, Schrodinger maestro |
| first_indexed | 2024-12-20T07:21:29Z |
| format | Article |
| id | doaj.art-7dee35d57635478e934694d9c55f2567 |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-20T07:21:29Z |
| publishDate | 2020-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-7dee35d57635478e934694d9c55f25672022-12-21T19:48:40ZengElsevierData in Brief2352-34092020-04-0129Data on molecular docking of naturally occurring flavonoids with biologically important targetsAnguraj Moulishankar0Karthikeyan Lakshmanan1Corresponding author.; Department of Pharmaceutical Chemistry, KMCH College of Pharmacy, Coimbatore-48, Tamil Nadu, IndiaDepartment of Pharmaceutical Chemistry, KMCH College of Pharmacy, Coimbatore-48, Tamil Nadu, IndiaFlavonoids in nature are known to possess various activities such as anti-inflammatory, antimicrobial, anticancer, antioxidant, neuroprotective, anti-HIV activities etc., The molecular docking was performed by 26 naturally occurring flavonoids with selected targets COX-2, hydroxyacyl-ACP dehydratase, tyrosinase from Agaricus bisporus, isomaltase from Saccharomyces cerevisiae, Human IkB kinase beta, Human ABC transporter, topoisomerase II, topoisomerase IV, N-myristoyltransferase from Candida albicans, Peptide deformylase from Pseudomonas aeruginosa, polypeptide deformylase from Streptococcus pneumoniae. The analysis was based on docking score, glide energy, interactions type (bond type and distance) and interaction with amino acids. The top 5 flavonoids with best docking score was reported. The in-silico results provided for 26 naturally occurring flavonoid shows that they reduce the risk of inflammation, cancer and infectious disease if people have taken in diet continuously. The provided docking data of flavonoids may be useful to synthesis novel drug candidate for the mentioned targets. Keywords: Molecular docking, Flavonoids, Antimicrobial, Anti-cancer, Anti-inflammatory, Glide, Schrodinger maestrohttp://www.sciencedirect.com/science/article/pii/S2352340920301372 |
| spellingShingle | Anguraj Moulishankar Karthikeyan Lakshmanan Data on molecular docking of naturally occurring flavonoids with biologically important targets Data in Brief |
| title | Data on molecular docking of naturally occurring flavonoids with biologically important targets |
| title_full | Data on molecular docking of naturally occurring flavonoids with biologically important targets |
| title_fullStr | Data on molecular docking of naturally occurring flavonoids with biologically important targets |
| title_full_unstemmed | Data on molecular docking of naturally occurring flavonoids with biologically important targets |
| title_short | Data on molecular docking of naturally occurring flavonoids with biologically important targets |
| title_sort | data on molecular docking of naturally occurring flavonoids with biologically important targets |
| url | http://www.sciencedirect.com/science/article/pii/S2352340920301372 |
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