Subdividing the superior longitudinal fasciculus using local quantitative MRI

The association fibers of the superior longitudinal fasciculus (SLF) connect parietal and frontal cortical regions in the human brain. The SLF comprises of three distinct sub-bundles, each presenting a different anatomical trajectory, and specific functional roles. Nevertheless, in vivo studies of t...

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Main Authors: Roey Schurr, Ady Zelman, Aviv A. Mezer
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:NeuroImage
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811919310304
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author Roey Schurr
Ady Zelman
Aviv A. Mezer
author_facet Roey Schurr
Ady Zelman
Aviv A. Mezer
author_sort Roey Schurr
collection DOAJ
description The association fibers of the superior longitudinal fasciculus (SLF) connect parietal and frontal cortical regions in the human brain. The SLF comprises of three distinct sub-bundles, each presenting a different anatomical trajectory, and specific functional roles. Nevertheless, in vivo studies of the SLF often consider the entire SLF complex as a single entity. In this work, we suggest a data-driven approach that relies on microstructure measurements for separating SLF-III from the rest of the SLF. We apply the SLF-III separation procedure in three independent datasets using parameters of diffusion MRI (fractional anisotropy), as well as relaxometry-based parameters (T1, T2, T2* and T2-weighted/T1-weighted). We show that the proposed procedure is reproducible across datasets and tractography algorithms. Finally, we suggest that differential crossing with different white-matter tracts is the source of the distinct MRI signatures of SLF-II and SLF-III.
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spelling doaj.art-7defe0fffaba4b4cbdc9c8607fbe443d2022-12-22T01:00:04ZengElsevierNeuroImage1095-95722020-03-01208116439Subdividing the superior longitudinal fasciculus using local quantitative MRIRoey Schurr0Ady Zelman1Aviv A. Mezer2Corresponding author.; Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, IsraelEdmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, IsraelEdmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, IsraelThe association fibers of the superior longitudinal fasciculus (SLF) connect parietal and frontal cortical regions in the human brain. The SLF comprises of three distinct sub-bundles, each presenting a different anatomical trajectory, and specific functional roles. Nevertheless, in vivo studies of the SLF often consider the entire SLF complex as a single entity. In this work, we suggest a data-driven approach that relies on microstructure measurements for separating SLF-III from the rest of the SLF. We apply the SLF-III separation procedure in three independent datasets using parameters of diffusion MRI (fractional anisotropy), as well as relaxometry-based parameters (T1, T2, T2* and T2-weighted/T1-weighted). We show that the proposed procedure is reproducible across datasets and tractography algorithms. Finally, we suggest that differential crossing with different white-matter tracts is the source of the distinct MRI signatures of SLF-II and SLF-III.http://www.sciencedirect.com/science/article/pii/S1053811919310304
spellingShingle Roey Schurr
Ady Zelman
Aviv A. Mezer
Subdividing the superior longitudinal fasciculus using local quantitative MRI
NeuroImage
title Subdividing the superior longitudinal fasciculus using local quantitative MRI
title_full Subdividing the superior longitudinal fasciculus using local quantitative MRI
title_fullStr Subdividing the superior longitudinal fasciculus using local quantitative MRI
title_full_unstemmed Subdividing the superior longitudinal fasciculus using local quantitative MRI
title_short Subdividing the superior longitudinal fasciculus using local quantitative MRI
title_sort subdividing the superior longitudinal fasciculus using local quantitative mri
url http://www.sciencedirect.com/science/article/pii/S1053811919310304
work_keys_str_mv AT roeyschurr subdividingthesuperiorlongitudinalfasciculususinglocalquantitativemri
AT adyzelman subdividingthesuperiorlongitudinalfasciculususinglocalquantitativemri
AT avivamezer subdividingthesuperiorlongitudinalfasciculususinglocalquantitativemri