Variables associated with progression of moderate-to-severe Crohn’s disease
Objective Determine the variables associated with hospitalisations in patients with Crohn’s disease and those associated with surgery, intestinal resection, hospital readmission, need for multiple operations and immunobiological agent use.Design A cross-sectional study was conducted from 2019 to 202...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2022-07-01
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| Series: | BMJ Open Gastroenterology |
| Online Access: | https://bmjopengastro.bmj.com/content/9/1/e001016.full |
| _version_ | 1797782560795787264 |
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| author | Carolina da Silva Beda Sacramento Marina Pamponet Motta Candida de Oliveira Alves Jaciane Araujo Mota Lina Maria Goes de Codes Reginaldo Freitas Ferreira Pedro de Almeida Silva Larissa do Prado Palmiro Rafael Miranda Barbosa Mariana Nery Andrade Vitor Damasceno Andrade Vitor Brandão Vasconcelos Bernardo Wasconcellos Thiara Eduardo Martins Netto Genoile Oliveira Santana |
| author_facet | Carolina da Silva Beda Sacramento Marina Pamponet Motta Candida de Oliveira Alves Jaciane Araujo Mota Lina Maria Goes de Codes Reginaldo Freitas Ferreira Pedro de Almeida Silva Larissa do Prado Palmiro Rafael Miranda Barbosa Mariana Nery Andrade Vitor Damasceno Andrade Vitor Brandão Vasconcelos Bernardo Wasconcellos Thiara Eduardo Martins Netto Genoile Oliveira Santana |
| author_sort | Carolina da Silva Beda Sacramento |
| collection | DOAJ |
| description | Objective Determine the variables associated with hospitalisations in patients with Crohn’s disease and those associated with surgery, intestinal resection, hospital readmission, need for multiple operations and immunobiological agent use.Design A cross-sectional study was conducted from 2019 to 2021, using two centres for inflammatory bowel diseases in the Brazilian Public Health System.Results This study included 220 patients. Only perianal disease was associated with hospitalisation (31.6% vs 13.0%, p=0.012). Stricturing or penetrating behaviour (35.8% vs 12.6%, p<0.001) and perianal disease (45.9% vs 9.9%, p<0.001) were associated with surgery. Ileal or ileocolonic location (80.0% vs 46.5%, p=0.044) and stricturing or penetrating behaviour (68.0% vs 11.2%, p<0.001) were associated with intestinal resection. Steroids use at first Crohn’s disease occurrence and postoperative complications were associated with hospital readmission and need for multiple operations, respectively. Age below 40 years at diagnosis (81.3% vs 62.0%, p=0.004), upper gastrointestinal tract involvement (21.8% vs 10.3%, p=0.040) and perianal disease (35.9% vs 16.3%, p<0.001) were associated with immunobiological agent use.Conclusion Perianal disease and stricturing or penetrating behaviour were associated with more than one significant outcome. Other variables related to Crohn’s disease progression were age below 40 years at diagnosis, an ileal or ileocolonic disease localisation, an upper gastrointestinal tract involvement, the use of steroids at the first Crohn’s disease occurrence and history of postoperative complications. These findings are similar to those in the countries with a high prevalence of Crohn’s disease. |
| first_indexed | 2024-03-13T00:12:40Z |
| format | Article |
| id | doaj.art-7df03c833acf46f99c880c39cd6a6130 |
| institution | Directory Open Access Journal |
| issn | 2054-4774 |
| language | English |
| last_indexed | 2024-03-13T00:12:40Z |
| publishDate | 2022-07-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Gastroenterology |
| spelling | doaj.art-7df03c833acf46f99c880c39cd6a61302023-07-12T09:30:06ZengBMJ Publishing GroupBMJ Open Gastroenterology2054-47742022-07-019110.1136/bmjgast-2022-001016Variables associated with progression of moderate-to-severe Crohn’s diseaseCarolina da Silva Beda Sacramento0Marina Pamponet Motta1Candida de Oliveira Alves2Jaciane Araujo Mota3Lina Maria Goes de Codes4Reginaldo Freitas Ferreira5Pedro de Almeida Silva6Larissa do Prado Palmiro7Rafael Miranda Barbosa8Mariana Nery Andrade9Vitor Damasceno Andrade10Vitor Brandão Vasconcelos11Bernardo Wasconcellos Thiara12Eduardo Martins Netto13Genoile Oliveira Santana14Department of Gastroenterology, Hospital Universitário Professor Edgard Santos, Salvador, BrazilDepartment of Gastroenterology, Hospital Universitário Professor Edgard Santos, Salvador, BrazilDepartment of Gastroenterology, Hospital Universitário Professor Edgard Santos, Salvador, BrazilDepartment of Gastroenterology, Hospital Geral Roberto Santos, Salvador, BrazilDepartment of Proctology, Hospital Universitario Professor Edgard Santos, Salvador, BrazilUniversidade do Estado da Bahia, Salvador, BrazilUniversidade do Estado da Bahia, Salvador, BrazilUniversidade do Estado da Bahia, Salvador, BrazilUniversidade do Estado da Bahia, Salvador, BrazilEscola Bahiana de Medicina e Saúde Pública, Salvador, BrazilUniversidade Salvador, Salvador, BrazilEscola Bahiana de Medicina e Saúde Pública, Salvador, BrazilUniversidade Salvador, Salvador, BrazilUniversidade Federal da Bahia, Salvador, BrazilCiências da Vida, Universidade do Estado da Bahia, Salvador, BrazilObjective Determine the variables associated with hospitalisations in patients with Crohn’s disease and those associated with surgery, intestinal resection, hospital readmission, need for multiple operations and immunobiological agent use.Design A cross-sectional study was conducted from 2019 to 2021, using two centres for inflammatory bowel diseases in the Brazilian Public Health System.Results This study included 220 patients. Only perianal disease was associated with hospitalisation (31.6% vs 13.0%, p=0.012). Stricturing or penetrating behaviour (35.8% vs 12.6%, p<0.001) and perianal disease (45.9% vs 9.9%, p<0.001) were associated with surgery. Ileal or ileocolonic location (80.0% vs 46.5%, p=0.044) and stricturing or penetrating behaviour (68.0% vs 11.2%, p<0.001) were associated with intestinal resection. Steroids use at first Crohn’s disease occurrence and postoperative complications were associated with hospital readmission and need for multiple operations, respectively. Age below 40 years at diagnosis (81.3% vs 62.0%, p=0.004), upper gastrointestinal tract involvement (21.8% vs 10.3%, p=0.040) and perianal disease (35.9% vs 16.3%, p<0.001) were associated with immunobiological agent use.Conclusion Perianal disease and stricturing or penetrating behaviour were associated with more than one significant outcome. Other variables related to Crohn’s disease progression were age below 40 years at diagnosis, an ileal or ileocolonic disease localisation, an upper gastrointestinal tract involvement, the use of steroids at the first Crohn’s disease occurrence and history of postoperative complications. These findings are similar to those in the countries with a high prevalence of Crohn’s disease.https://bmjopengastro.bmj.com/content/9/1/e001016.full |
| spellingShingle | Carolina da Silva Beda Sacramento Marina Pamponet Motta Candida de Oliveira Alves Jaciane Araujo Mota Lina Maria Goes de Codes Reginaldo Freitas Ferreira Pedro de Almeida Silva Larissa do Prado Palmiro Rafael Miranda Barbosa Mariana Nery Andrade Vitor Damasceno Andrade Vitor Brandão Vasconcelos Bernardo Wasconcellos Thiara Eduardo Martins Netto Genoile Oliveira Santana Variables associated with progression of moderate-to-severe Crohn’s disease BMJ Open Gastroenterology |
| title | Variables associated with progression of moderate-to-severe Crohn’s disease |
| title_full | Variables associated with progression of moderate-to-severe Crohn’s disease |
| title_fullStr | Variables associated with progression of moderate-to-severe Crohn’s disease |
| title_full_unstemmed | Variables associated with progression of moderate-to-severe Crohn’s disease |
| title_short | Variables associated with progression of moderate-to-severe Crohn’s disease |
| title_sort | variables associated with progression of moderate to severe crohn s disease |
| url | https://bmjopengastro.bmj.com/content/9/1/e001016.full |
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