Probiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota
Abstract Increasing evidence indicates that alterations in gut microbiota are associated with mammalian development and physiology. The gut microbiota has been proposed as an essential player in metabolic diseases including brain health. This study aimed to determine the impact of probiotics on dege...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-77587-w |
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| author | Mi Ri Park Minhye Shin Daye Mun Seong-Yeop Jeong Do-Youn Jeong Minho Song Gwangpyo Ko Tatsuya Unno Younghoon Kim Sangnam Oh |
| author_facet | Mi Ri Park Minhye Shin Daye Mun Seong-Yeop Jeong Do-Youn Jeong Minho Song Gwangpyo Ko Tatsuya Unno Younghoon Kim Sangnam Oh |
| author_sort | Mi Ri Park |
| collection | DOAJ |
| description | Abstract Increasing evidence indicates that alterations in gut microbiota are associated with mammalian development and physiology. The gut microbiota has been proposed as an essential player in metabolic diseases including brain health. This study aimed to determine the impact of probiotics on degenerative changes in the gut microbiota and cognitive behavior. Assessment of various behavioral and physiological functions was performed using Y-maze tests, wheel running tests, accelerated rotarod tests, balance beam tests, and forced swimming tests (FSTs), using adult mice after 50 weeks of administering living probiotic bacterium Lactobacillus fermentum strain JDFM216 or a vehicle. Immunomodulatory function was investigated using immune organs, immune cells and immune molecules in the mice, and gut microbiota was also evaluated in their feces. Notably, the L. fermentum JDFM216-treated group showed significantly better performance in the behavior tests (P < 0.05) as well as improved phagocytic activity of macrophages, enhanced sIgA production, and stimulated immune cells (P < 0.05). In aged mice, we observed decreases in species belonging to the Porphyromonadaceae family and the Lactobacillus genus when compared to young mice. While administering the supplementation of L. fermentum JDFM216 to aged mice did not shift the whole gut microbiota, the abundance of Lactobacillus species was significantly increased (P < 0.05). Our findings suggested that L. fermentum JDFM216 also provided beneficial effects on the regulation of immune responses, which has promising implications for functional foods. Taken together, L. fermentum JDFM216 could confer the benefit of improving health with enhanced cognition, physiological behavior, and immunity by modulating the gut microbiota. |
| first_indexed | 2024-12-23T04:08:20Z |
| format | Article |
| id | doaj.art-7df0e229d0e04aceb8be26f8e14e956d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-23T04:08:20Z |
| publishDate | 2020-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-7df0e229d0e04aceb8be26f8e14e956d2022-12-21T18:00:34ZengNature PortfolioScientific Reports2045-23222020-12-0110111310.1038/s41598-020-77587-wProbiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiotaMi Ri Park0Minhye Shin1Daye Mun2Seong-Yeop Jeong3Do-Youn Jeong4Minho Song5Gwangpyo Ko6Tatsuya Unno7Younghoon Kim8Sangnam Oh9Department of Animal Science and Institute of Milk Genomics, Jeonbuk National UniversityDepartment of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National UniversityDepartment of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National UniversityMicrobial Institute for Fermentation IndustryMicrobial Institute for Fermentation IndustryDivision of Animal and Dairy Science, Chungnam National UniversitySubtropical/Tropical Organism Gene Bank, Jeju National UniversitySubtropical/Tropical Organism Gene Bank, Jeju National UniversityDepartment of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National UniversityDepartment of Functional Food and Biotechnology, Jeonju UniversityAbstract Increasing evidence indicates that alterations in gut microbiota are associated with mammalian development and physiology. The gut microbiota has been proposed as an essential player in metabolic diseases including brain health. This study aimed to determine the impact of probiotics on degenerative changes in the gut microbiota and cognitive behavior. Assessment of various behavioral and physiological functions was performed using Y-maze tests, wheel running tests, accelerated rotarod tests, balance beam tests, and forced swimming tests (FSTs), using adult mice after 50 weeks of administering living probiotic bacterium Lactobacillus fermentum strain JDFM216 or a vehicle. Immunomodulatory function was investigated using immune organs, immune cells and immune molecules in the mice, and gut microbiota was also evaluated in their feces. Notably, the L. fermentum JDFM216-treated group showed significantly better performance in the behavior tests (P < 0.05) as well as improved phagocytic activity of macrophages, enhanced sIgA production, and stimulated immune cells (P < 0.05). In aged mice, we observed decreases in species belonging to the Porphyromonadaceae family and the Lactobacillus genus when compared to young mice. While administering the supplementation of L. fermentum JDFM216 to aged mice did not shift the whole gut microbiota, the abundance of Lactobacillus species was significantly increased (P < 0.05). Our findings suggested that L. fermentum JDFM216 also provided beneficial effects on the regulation of immune responses, which has promising implications for functional foods. Taken together, L. fermentum JDFM216 could confer the benefit of improving health with enhanced cognition, physiological behavior, and immunity by modulating the gut microbiota.https://doi.org/10.1038/s41598-020-77587-w |
| spellingShingle | Mi Ri Park Minhye Shin Daye Mun Seong-Yeop Jeong Do-Youn Jeong Minho Song Gwangpyo Ko Tatsuya Unno Younghoon Kim Sangnam Oh Probiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota Scientific Reports |
| title | Probiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota |
| title_full | Probiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota |
| title_fullStr | Probiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota |
| title_full_unstemmed | Probiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota |
| title_short | Probiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota |
| title_sort | probiotic lactobacillus fermentum strain jdfm216 improves cognitive behavior and modulates immune response with gut microbiota |
| url | https://doi.org/10.1038/s41598-020-77587-w |
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