Ginsenoside Rg12, a new dammarane-type triterpene saponin from Panax ginseng root
Background: Panax ginseng has been used as Korean medicine for various diseases. It has antioxidant, hypotensive, sedative, analgesic, and endocrine activities. Dammarane-type triterpenes from the plant have various beneficial effects. Methods: A dammarane-type triterpene saponin was isolated from P...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-10-01
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| Series: | Journal of Ginseng Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1226845316300549 |
| _version_ | 1828908046200340480 |
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| author | Dong Gu Lee Jaemin Lee Ik-Hyun Cho Hak-Jae Kim Sang-Won Lee Young-Ock Kim Chun-Gun Park Sanghyun Lee |
| author_facet | Dong Gu Lee Jaemin Lee Ik-Hyun Cho Hak-Jae Kim Sang-Won Lee Young-Ock Kim Chun-Gun Park Sanghyun Lee |
| author_sort | Dong Gu Lee |
| collection | DOAJ |
| description | Background: Panax ginseng has been used as Korean medicine for various diseases. It has antioxidant, hypotensive, sedative, analgesic, and endocrine activities. Dammarane-type triterpenes from the plant have various beneficial effects.
Methods: A dammarane-type triterpene saponin was isolated from P. ginseng root through chromatography such as repeated column chromatography and medium pressure liquid chromatography.
Results and conclusion: New dammarane-type triterpene saponin was isolated for the first time from nature. The structure was elucidated as ginsenoside Rg12 (1) based on spectral data. There may be good materials from P. ginseng for the development of industrial applications such as nutraceutical, pharmaceutical, and cosmeceutical purposes. |
| first_indexed | 2024-12-13T18:04:23Z |
| format | Article |
| id | doaj.art-7df767ff6b1b4700b4c878ddb6375d52 |
| institution | Directory Open Access Journal |
| issn | 1226-8453 |
| language | English |
| last_indexed | 2024-12-13T18:04:23Z |
| publishDate | 2017-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ginseng Research |
| spelling | doaj.art-7df767ff6b1b4700b4c878ddb6375d522022-12-21T23:36:07ZengElsevierJournal of Ginseng Research1226-84532017-10-0141453153310.1016/j.jgr.2016.10.002Ginsenoside Rg12, a new dammarane-type triterpene saponin from Panax ginseng rootDong Gu Lee0Jaemin Lee1Ik-Hyun Cho2Hak-Jae Kim3Sang-Won Lee4Young-Ock Kim5Chun-Gun Park6Sanghyun Lee7Department of Integrative Plant Science, Chung-Ang University, Anseong, Republic of KoreaDepartment of Integrative Plant Science, Chung-Ang University, Anseong, Republic of KoreaDepartment of Convergence Medical Science, Brain Korea 21 Plus Program, and Institute of Korean Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Republic of KoreaDepartment of Clinical Pharmacology, College of Medicine, Soonchunhyang University, Cheonan, Republic of KoreaDepartment of Medicinal Crop Research Institute, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong, Republic of KoreaDepartment of Medicinal Crop Research Institute, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong, Republic of KoreaDepartment of Medicinal Crop Research Institute, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong, Republic of KoreaDepartment of Integrative Plant Science, Chung-Ang University, Anseong, Republic of KoreaBackground: Panax ginseng has been used as Korean medicine for various diseases. It has antioxidant, hypotensive, sedative, analgesic, and endocrine activities. Dammarane-type triterpenes from the plant have various beneficial effects. Methods: A dammarane-type triterpene saponin was isolated from P. ginseng root through chromatography such as repeated column chromatography and medium pressure liquid chromatography. Results and conclusion: New dammarane-type triterpene saponin was isolated for the first time from nature. The structure was elucidated as ginsenoside Rg12 (1) based on spectral data. There may be good materials from P. ginseng for the development of industrial applications such as nutraceutical, pharmaceutical, and cosmeceutical purposes.http://www.sciencedirect.com/science/article/pii/S1226845316300549dammarane-type triterpene saponinginsenoside Rg12Panax ginsengwhite ginseng |
| spellingShingle | Dong Gu Lee Jaemin Lee Ik-Hyun Cho Hak-Jae Kim Sang-Won Lee Young-Ock Kim Chun-Gun Park Sanghyun Lee Ginsenoside Rg12, a new dammarane-type triterpene saponin from Panax ginseng root Journal of Ginseng Research dammarane-type triterpene saponin ginsenoside Rg12 Panax ginseng white ginseng |
| title | Ginsenoside Rg12, a new dammarane-type triterpene saponin from Panax ginseng root |
| title_full | Ginsenoside Rg12, a new dammarane-type triterpene saponin from Panax ginseng root |
| title_fullStr | Ginsenoside Rg12, a new dammarane-type triterpene saponin from Panax ginseng root |
| title_full_unstemmed | Ginsenoside Rg12, a new dammarane-type triterpene saponin from Panax ginseng root |
| title_short | Ginsenoside Rg12, a new dammarane-type triterpene saponin from Panax ginseng root |
| title_sort | ginsenoside rg12 a new dammarane type triterpene saponin from panax ginseng root |
| topic | dammarane-type triterpene saponin ginsenoside Rg12 Panax ginseng white ginseng |
| url | http://www.sciencedirect.com/science/article/pii/S1226845316300549 |
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