Therapeutic Target Discovery Using High-Throughput Genetic Screens in Acute Myeloid Leukemia

Therapeutic Target Discovery Using High-Throughput Genetic Screens in Acute Myeloid Leukemia

The development of high-throughput gene manipulating tools such as short hairpin RNA (shRNA) and CRISPR/Cas9 libraries has enabled robust characterization of novel functional genes contributing to the pathological states of the diseases. In acute myeloid leukemia (AML), these genetic screen approach...

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Bibliographic Details
Main Authors: Qiao Liu, Michelle Garcia, Shaoyuan Wang, Chun-Wei Chen
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cells
Subjects:
high-throughput
genetic screen
CRISPR
shRNA
genome-wide
epigenetics
Online Access:https://www.mdpi.com/2073-4409/9/8/1888

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