Covid-19 and thrombotic thrombocytopenic purpura: a case report
The clinical presentation of Covid-19 varies from being asymptomatic to developing acute respiratory distress syndrome and multi-organ dysfunction. The diffuse microvascular thrombi in multiple organs seen in the autopsy of Covid-19 patients are similar to that of thrombotic microangiopathy (TMA)....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Pakistan Medical Association
2023-02-01
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| Series: | Journal of the Pakistan Medical Association |
| Online Access: | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/4992 |
| _version_ | 1797820943740960768 |
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| author | Muhammad Zain Mushtaq Saad Bin Zafar Mahmood Syed Ahsan Ali Muhammad Usman Shaikh |
| author_facet | Muhammad Zain Mushtaq Saad Bin Zafar Mahmood Syed Ahsan Ali Muhammad Usman Shaikh |
| author_sort | Muhammad Zain Mushtaq |
| collection | DOAJ |
| description |
The clinical presentation of Covid-19 varies from being asymptomatic to developing acute respiratory distress syndrome and multi-organ dysfunction. The diffuse microvascular thrombi in multiple organs seen in the autopsy of Covid-19 patients are similar to that of thrombotic microangiopathy (TMA). TMA is characterised by thrombus formation in the microvasculature with laboratory findings of microangiopathic haemolytic anaemia (MAHA) and thrombocytopenia. A 49-year-old male presented to the Aga Khan University Hospital, Karachi. with fever, diarrhoea, altered level of consciousness, and a positive nasopharyngeal swab for SARS-CoV-2. He developed severe thrombocytopenia, MAHA with 5.8% schistocytes, and worsening renal function on the sixth day of admission. Diagnosis of thrombotic thrombocytopenic purpura (TTP) was established based on PLASMIC score, and he was successfully treated with intravenous (IV) Methylprednisolone, therapeutic plasma exchange and IV Rituximab.
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| first_indexed | 2024-03-13T09:45:36Z |
| format | Article |
| id | doaj.art-7e00e3f017c84f0595c7928a34ccf401 |
| institution | Directory Open Access Journal |
| issn | 0030-9982 |
| language | English |
| last_indexed | 2024-03-13T09:45:36Z |
| publishDate | 2023-02-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj.art-7e00e3f017c84f0595c7928a34ccf4012023-05-25T04:20:47ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822023-02-0173210.47391/JPMA.4992Covid-19 and thrombotic thrombocytopenic purpura: a case reportMuhammad Zain Mushtaq0Saad Bin Zafar Mahmood1Syed Ahsan Ali2Muhammad Usman Shaikh3Department of Medicine, Aga Khan University Hospital, Karachi, PakistanDepartment of Medicine, Aga Khan University Hospital, Karachi, PakistanDepartment of Medicine, Aga Khan University Hospital, Karachi, PakistanDepartment of Oncology, Aga Khan University Hospital, Karachi, Pakistan The clinical presentation of Covid-19 varies from being asymptomatic to developing acute respiratory distress syndrome and multi-organ dysfunction. The diffuse microvascular thrombi in multiple organs seen in the autopsy of Covid-19 patients are similar to that of thrombotic microangiopathy (TMA). TMA is characterised by thrombus formation in the microvasculature with laboratory findings of microangiopathic haemolytic anaemia (MAHA) and thrombocytopenia. A 49-year-old male presented to the Aga Khan University Hospital, Karachi. with fever, diarrhoea, altered level of consciousness, and a positive nasopharyngeal swab for SARS-CoV-2. He developed severe thrombocytopenia, MAHA with 5.8% schistocytes, and worsening renal function on the sixth day of admission. Diagnosis of thrombotic thrombocytopenic purpura (TTP) was established based on PLASMIC score, and he was successfully treated with intravenous (IV) Methylprednisolone, therapeutic plasma exchange and IV Rituximab. ---Continue https://www.ojs.jpma.org.pk/index.php/public_html/article/view/4992 |
| spellingShingle | Muhammad Zain Mushtaq Saad Bin Zafar Mahmood Syed Ahsan Ali Muhammad Usman Shaikh Covid-19 and thrombotic thrombocytopenic purpura: a case report Journal of the Pakistan Medical Association |
| title | Covid-19 and thrombotic thrombocytopenic purpura: a case report |
| title_full | Covid-19 and thrombotic thrombocytopenic purpura: a case report |
| title_fullStr | Covid-19 and thrombotic thrombocytopenic purpura: a case report |
| title_full_unstemmed | Covid-19 and thrombotic thrombocytopenic purpura: a case report |
| title_short | Covid-19 and thrombotic thrombocytopenic purpura: a case report |
| title_sort | covid 19 and thrombotic thrombocytopenic purpura a case report |
| url | https://www.ojs.jpma.org.pk/index.php/public_html/article/view/4992 |
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