Descriptive study of relationship between cardio-ankle vascular index and biomarkers in vascular-related diseases
Background: Cardio-ankle vascular index (CAVI) was supposed to be an independent predictor for vascular-related events. Biomarkers such as homocysteine (Hcy), N-terminal pro-brain natriuretic peptide (NT-proBNP), and urine albumin(microalbumin) (UAE) have involved the pathophysiological development...
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Format: | Article |
Language: | English |
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Taylor & Francis Group
2017-07-01
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Series: | Clinical and Experimental Hypertension |
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Online Access: | http://dx.doi.org/10.1080/10641963.2016.1273946 |
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author | Jinbo Liu Huan Liu Hongwei Zhao Guangyun Shang Yingyan Zhou Lihong Li Hongyu Wang |
author_facet | Jinbo Liu Huan Liu Hongwei Zhao Guangyun Shang Yingyan Zhou Lihong Li Hongyu Wang |
author_sort | Jinbo Liu |
collection | DOAJ |
description | Background: Cardio-ankle vascular index (CAVI) was supposed to be an independent predictor for vascular-related events. Biomarkers such as homocysteine (Hcy), N-terminal pro-brain natriuretic peptide (NT-proBNP), and urine albumin(microalbumin) (UAE) have involved the pathophysiological development of arteriosclerosis. The present study was to investigate relationship between CAVI and biomarkers in vascular-related diseases. Methods: A total of 656 subjects (M/F 272/384) from department of Vascular Medicine were enrolled into our study. They were divided into four groups according to the numbers of suffered diseases, healthy group (group 0: subjects without diseases of hypertension, diabetes mellitus (DM), coronary heart disease (CHD); n = 186), group 1 (with one of diseases of hypertension, CHD, DM; n = 237), group 2 (with two of diseases of hypertension, CHD, DM; n = 174), and group 3 (with all diseases of hypertension, CHD, DM; n = 59). CAVI was measured by VS-1000 apparatus. Results: CAVI was increasing with increasing numbers of suffered vascular-related diseases. Similar results were found in the parameters of biomarkers such as Hcy, log NT-ProBNP, and log UAE. There were positive correlation between log NT-proBNP, Hcy, log UAE, and CAVI in the entire study group and nonhealthy group. Positive correlation between log UAE and CAVI were found in the entire study group after adjusting for age, body mass index (BMI), blood pressure, uric acid, and lipids. Multivariate analysis showed that log UAE was an independent associating factor of CAVI in all subjects. Conclusions: CAVI was significantly higher in subjects with hypertension, CHD, and DM. There was correlation between arterial stiffness and biomarkers such as NT-proBNP, Hcy, and UAE. |
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issn | 1064-1963 1525-6006 |
language | English |
last_indexed | 2024-03-11T23:46:03Z |
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publisher | Taylor & Francis Group |
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series | Clinical and Experimental Hypertension |
spelling | doaj.art-7e02eb7e57324426b6ab769f9bb6c0ca2023-09-19T09:24:45ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062017-07-0139546847210.1080/10641963.2016.12739461273946Descriptive study of relationship between cardio-ankle vascular index and biomarkers in vascular-related diseasesJinbo Liu0Huan Liu1Hongwei Zhao2Guangyun Shang3Yingyan Zhou4Lihong Li5Hongyu Wang6Peking University Shougang HospitalPeking University Shougang HospitalPeking University Shougang HospitalPeking University Shougang HospitalPeking University Shougang HospitalPeking University Shougang HospitalPeking University Shougang HospitalBackground: Cardio-ankle vascular index (CAVI) was supposed to be an independent predictor for vascular-related events. Biomarkers such as homocysteine (Hcy), N-terminal pro-brain natriuretic peptide (NT-proBNP), and urine albumin(microalbumin) (UAE) have involved the pathophysiological development of arteriosclerosis. The present study was to investigate relationship between CAVI and biomarkers in vascular-related diseases. Methods: A total of 656 subjects (M/F 272/384) from department of Vascular Medicine were enrolled into our study. They were divided into four groups according to the numbers of suffered diseases, healthy group (group 0: subjects without diseases of hypertension, diabetes mellitus (DM), coronary heart disease (CHD); n = 186), group 1 (with one of diseases of hypertension, CHD, DM; n = 237), group 2 (with two of diseases of hypertension, CHD, DM; n = 174), and group 3 (with all diseases of hypertension, CHD, DM; n = 59). CAVI was measured by VS-1000 apparatus. Results: CAVI was increasing with increasing numbers of suffered vascular-related diseases. Similar results were found in the parameters of biomarkers such as Hcy, log NT-ProBNP, and log UAE. There were positive correlation between log NT-proBNP, Hcy, log UAE, and CAVI in the entire study group and nonhealthy group. Positive correlation between log UAE and CAVI were found in the entire study group after adjusting for age, body mass index (BMI), blood pressure, uric acid, and lipids. Multivariate analysis showed that log UAE was an independent associating factor of CAVI in all subjects. Conclusions: CAVI was significantly higher in subjects with hypertension, CHD, and DM. There was correlation between arterial stiffness and biomarkers such as NT-proBNP, Hcy, and UAE.http://dx.doi.org/10.1080/10641963.2016.1273946arterial stiffnesscardio-ankle vascular indexhomocysteinen-terminal pro-brain natriuretic peptideurine albumin(microalbumin) |
spellingShingle | Jinbo Liu Huan Liu Hongwei Zhao Guangyun Shang Yingyan Zhou Lihong Li Hongyu Wang Descriptive study of relationship between cardio-ankle vascular index and biomarkers in vascular-related diseases Clinical and Experimental Hypertension arterial stiffness cardio-ankle vascular index homocysteine n-terminal pro-brain natriuretic peptide urine albumin(microalbumin) |
title | Descriptive study of relationship between cardio-ankle vascular index and biomarkers in vascular-related diseases |
title_full | Descriptive study of relationship between cardio-ankle vascular index and biomarkers in vascular-related diseases |
title_fullStr | Descriptive study of relationship between cardio-ankle vascular index and biomarkers in vascular-related diseases |
title_full_unstemmed | Descriptive study of relationship between cardio-ankle vascular index and biomarkers in vascular-related diseases |
title_short | Descriptive study of relationship between cardio-ankle vascular index and biomarkers in vascular-related diseases |
title_sort | descriptive study of relationship between cardio ankle vascular index and biomarkers in vascular related diseases |
topic | arterial stiffness cardio-ankle vascular index homocysteine n-terminal pro-brain natriuretic peptide urine albumin(microalbumin) |
url | http://dx.doi.org/10.1080/10641963.2016.1273946 |
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