Pharmacokinetics of Orally Applied Cannabinoids and Medical Marijuana Extracts in Mouse Nervous Tissue and Plasma: Relevance for Pain Treatment
Cannabis sativa plants contain a multitude of bioactive substances, which show broad variability between different plant strains. Of the more than a hundred naturally occurring phytocannabinoids, Δ9-Tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) have been the most extensively studied, but wheth...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/3/853 |
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| author | Cristiana Dumbraveanu Katharina Strommer Meinolf Wonnemann Jeiny Luna Choconta Astrid Neumann Michaela Kress Theodora Kalpachidou Kai K. Kummer |
| author_facet | Cristiana Dumbraveanu Katharina Strommer Meinolf Wonnemann Jeiny Luna Choconta Astrid Neumann Michaela Kress Theodora Kalpachidou Kai K. Kummer |
| author_sort | Cristiana Dumbraveanu |
| collection | DOAJ |
| description | Cannabis sativa plants contain a multitude of bioactive substances, which show broad variability between different plant strains. Of the more than a hundred naturally occurring phytocannabinoids, Δ9-Tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) have been the most extensively studied, but whether and how the lesser investigated compounds in plant extracts affect bioavailability or biological effects of Δ9-THC or CBD is not known. We therefore performed a first pilot study to assess THC concentrations in plasma, spinal cord and brain after oral administration of THC compared to medical marijuana extracts rich in THC or depleted of THC. Δ9-THC levels were higher in mice receiving the THC-rich extract. Surprisingly, only orally applied CBD but not THC alleviated mechanical hypersensitivity in the mouse spared nerve injury model, favoring CBD as an analgesic compound for which fewer unwanted psychoactive effects are to be expected. |
| first_indexed | 2024-03-11T06:02:18Z |
| format | Article |
| id | doaj.art-7e045e39c4f0403093dae03fde7ef500 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-11T06:02:18Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-7e045e39c4f0403093dae03fde7ef5002023-11-17T13:15:18ZengMDPI AGPharmaceutics1999-49232023-03-0115385310.3390/pharmaceutics15030853Pharmacokinetics of Orally Applied Cannabinoids and Medical Marijuana Extracts in Mouse Nervous Tissue and Plasma: Relevance for Pain TreatmentCristiana Dumbraveanu0Katharina Strommer1Meinolf Wonnemann2Jeiny Luna Choconta3Astrid Neumann4Michaela Kress5Theodora Kalpachidou6Kai K. Kummer7Institute of Physiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaBionorica Research GmbH, 6020 Innsbruck, AustriaIndependent Researcher, 92318 Neumarkt, GermanyInstitute of Physiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaBionorica Research GmbH, 6020 Innsbruck, AustriaInstitute of Physiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaInstitute of Physiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaInstitute of Physiology, Medical University of Innsbruck, 6020 Innsbruck, AustriaCannabis sativa plants contain a multitude of bioactive substances, which show broad variability between different plant strains. Of the more than a hundred naturally occurring phytocannabinoids, Δ9-Tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) have been the most extensively studied, but whether and how the lesser investigated compounds in plant extracts affect bioavailability or biological effects of Δ9-THC or CBD is not known. We therefore performed a first pilot study to assess THC concentrations in plasma, spinal cord and brain after oral administration of THC compared to medical marijuana extracts rich in THC or depleted of THC. Δ9-THC levels were higher in mice receiving the THC-rich extract. Surprisingly, only orally applied CBD but not THC alleviated mechanical hypersensitivity in the mouse spared nerve injury model, favoring CBD as an analgesic compound for which fewer unwanted psychoactive effects are to be expected.https://www.mdpi.com/1999-4923/15/3/853medical marijuanaTHCtetrahydrocannabinolCBDcannabidiolbioavailability |
| spellingShingle | Cristiana Dumbraveanu Katharina Strommer Meinolf Wonnemann Jeiny Luna Choconta Astrid Neumann Michaela Kress Theodora Kalpachidou Kai K. Kummer Pharmacokinetics of Orally Applied Cannabinoids and Medical Marijuana Extracts in Mouse Nervous Tissue and Plasma: Relevance for Pain Treatment Pharmaceutics medical marijuana THC tetrahydrocannabinol CBD cannabidiol bioavailability |
| title | Pharmacokinetics of Orally Applied Cannabinoids and Medical Marijuana Extracts in Mouse Nervous Tissue and Plasma: Relevance for Pain Treatment |
| title_full | Pharmacokinetics of Orally Applied Cannabinoids and Medical Marijuana Extracts in Mouse Nervous Tissue and Plasma: Relevance for Pain Treatment |
| title_fullStr | Pharmacokinetics of Orally Applied Cannabinoids and Medical Marijuana Extracts in Mouse Nervous Tissue and Plasma: Relevance for Pain Treatment |
| title_full_unstemmed | Pharmacokinetics of Orally Applied Cannabinoids and Medical Marijuana Extracts in Mouse Nervous Tissue and Plasma: Relevance for Pain Treatment |
| title_short | Pharmacokinetics of Orally Applied Cannabinoids and Medical Marijuana Extracts in Mouse Nervous Tissue and Plasma: Relevance for Pain Treatment |
| title_sort | pharmacokinetics of orally applied cannabinoids and medical marijuana extracts in mouse nervous tissue and plasma relevance for pain treatment |
| topic | medical marijuana THC tetrahydrocannabinol CBD cannabidiol bioavailability |
| url | https://www.mdpi.com/1999-4923/15/3/853 |
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