Efficiency of delta-sleep inducing peptide in neurotransmitter metabolism disturbances
The effect of single delta;sleep inducing peptide (DSIP- 60g/kg body weight) administration on the parameters of rat brainmetabolism under the conditions of chronic amphetamine (2.5mg/kg body weight, 21 days) or Madopar-125 in a dose corresponding to 50 mg L;DOPA/kg body weight (30 days) was investi...
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2017-02-01
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| Series: | Анналы клинической и экспериментальной неврологии |
| Subjects: | |
| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/358/261 |
| _version_ | 1811244275652886528 |
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| author | E. L. Dovedova L. M. Gershtein |
| author_facet | E. L. Dovedova L. M. Gershtein |
| author_sort | E. L. Dovedova |
| collection | DOAJ |
| description | The effect of single delta;sleep inducing peptide (DSIP- 60g/kg body weight) administration on the parameters of rat brainmetabolism under the conditions of chronic amphetamine (2.5mg/kg body weight, 21 days) or Madopar-125 in a dose corresponding to 50 mg L;DOPA/kg body weight (30 days) was investigated. The neurotransmitter systems were evaluated based onthe content of biogenic amines, their metabolites, and activity ofneurotransmitter-catabolising enzymes: serotoninergic systemwas characterized by MAO A activity, serotonin (5-OT) and 5-hydroxyindolil acetic acid (5-HIAA) content, and dopaminergic system by MAO B activity, dopamine (DA), noradrenalin(NA), and homovanilliс acid (HVA) content in the cortex andcaudate nucleus of control and experimental rats. The changesin neurotransmitter metabolism parameters induced by DA-activating substances had certain specificity. Characteristics ofthe corrective effect of DSIP under the conditions of amphetamine or L;DOPA action were demonstrated depending on thetype of a pharmacologic agent or brain structures. It is proposedthat DSIP effect in vivo is based on the activation of serotonergic system and normalizes brain metabolism, which leads toadaptive behavior of animals. A possibility of using DSIP, byanalogy with a drug Deltaran, for the treatment of depressions ofvarious origin, cerebral ischemia, etc. is discussed. |
| first_indexed | 2024-04-12T14:23:15Z |
| format | Article |
| id | doaj.art-7e083f04be6c4ef8b00589285f74676d |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-04-12T14:23:15Z |
| publishDate | 2017-02-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-7e083f04be6c4ef8b00589285f74676d2022-12-22T03:29:32ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332017-02-0134343810.17816/psaic358261Efficiency of delta-sleep inducing peptide in neurotransmitter metabolism disturbancesE. L. Dovedova0L. M. Gershtein1Research Center of Neurology, Russian Academy of Medical Sciences, MoscowResearch Center of Neurology, Russian Academy of Medical Sciences, MoscowThe effect of single delta;sleep inducing peptide (DSIP- 60g/kg body weight) administration on the parameters of rat brainmetabolism under the conditions of chronic amphetamine (2.5mg/kg body weight, 21 days) or Madopar-125 in a dose corresponding to 50 mg L;DOPA/kg body weight (30 days) was investigated. The neurotransmitter systems were evaluated based onthe content of biogenic amines, their metabolites, and activity ofneurotransmitter-catabolising enzymes: serotoninergic systemwas characterized by MAO A activity, serotonin (5-OT) and 5-hydroxyindolil acetic acid (5-HIAA) content, and dopaminergic system by MAO B activity, dopamine (DA), noradrenalin(NA), and homovanilliс acid (HVA) content in the cortex andcaudate nucleus of control and experimental rats. The changesin neurotransmitter metabolism parameters induced by DA-activating substances had certain specificity. Characteristics ofthe corrective effect of DSIP under the conditions of amphetamine or L;DOPA action were demonstrated depending on thetype of a pharmacologic agent or brain structures. It is proposedthat DSIP effect in vivo is based on the activation of serotonergic system and normalizes brain metabolism, which leads toadaptive behavior of animals. A possibility of using DSIP, byanalogy with a drug Deltaran, for the treatment of depressions ofvarious origin, cerebral ischemia, etc. is discussed.https://annaly-nevrologii.com/journal/pathID/article/viewFile/358/261delta-sleep inducing peptideneurotransmittersproteinsamphetaminel-dopabrain structures |
| spellingShingle | E. L. Dovedova L. M. Gershtein Efficiency of delta-sleep inducing peptide in neurotransmitter metabolism disturbances Анналы клинической и экспериментальной неврологии delta-sleep inducing peptide neurotransmitters proteins amphetamine l-dopa brain structures |
| title | Efficiency of delta-sleep inducing peptide in neurotransmitter metabolism disturbances |
| title_full | Efficiency of delta-sleep inducing peptide in neurotransmitter metabolism disturbances |
| title_fullStr | Efficiency of delta-sleep inducing peptide in neurotransmitter metabolism disturbances |
| title_full_unstemmed | Efficiency of delta-sleep inducing peptide in neurotransmitter metabolism disturbances |
| title_short | Efficiency of delta-sleep inducing peptide in neurotransmitter metabolism disturbances |
| title_sort | efficiency of delta sleep inducing peptide in neurotransmitter metabolism disturbances |
| topic | delta-sleep inducing peptide neurotransmitters proteins amphetamine l-dopa brain structures |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/358/261 |
| work_keys_str_mv | AT eldovedova efficiencyofdeltasleepinducingpeptideinneurotransmittermetabolismdisturbances AT lmgershtein efficiencyofdeltasleepinducingpeptideinneurotransmittermetabolismdisturbances |