Pulmonary cytotoxicity induced by bleomycin and methotrexate
Early detection of drug-induced pulmonary parenchymal injuries is often hampered by nonspecific clinical and X-ray manifestations. The diagnosis is usually based on a history of drug use, clinical and X-ray presentation, and exclusion of other causes of lung tissue injury.Chemical preparations most...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Luchevaya Diagnostika, LLC
2016-03-01
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| Series: | Вестник рентгенологии и радиологии |
| Subjects: | |
| Online Access: | https://www.russianradiology.ru/jour/article/view/69 |
| _version_ | 1797341696629932032 |
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| author | Zh, V, Sheykh A. O. Krutskevich N. S. Drebushevskiy S. N. Shvayko A. P. Dunaev V. G. Alekseev |
| author_facet | Zh, V, Sheykh A. O. Krutskevich N. S. Drebushevskiy S. N. Shvayko A. P. Dunaev V. G. Alekseev |
| author_sort | Zh, V, Sheykh |
| collection | DOAJ |
| description | Early detection of drug-induced pulmonary parenchymal injuries is often hampered by nonspecific clinical and X-ray manifestations. The diagnosis is usually based on a history of drug use, clinical and X-ray presentation, and exclusion of other causes of lung tissue injury.Chemical preparations most commonly cause pathological pulmonary changes. Overall, about 10% of all patients receiving chemotherapy develop pathological changes in the lung parenchyma. The main chemical preparations causing lung injury are bleomycin, methotrexate, carmustine, busulfan, and cyclophosphamide.Out of all examination techniques, computed tomography is most sensitive in determining the presence, specific features, and trends in the development of drug-induced pulmonary parenchymaldisease.The paper gives the data available in the literature and 2 clinical observations of pulmonary parenchymal disease induced by bleomycin and methotrexate. |
| first_indexed | 2024-03-08T10:22:46Z |
| format | Article |
| id | doaj.art-7e087cc7abbd4bf3a5461f5328d4a677 |
| institution | Directory Open Access Journal |
| issn | 0042-4676 2619-0478 |
| language | English |
| last_indexed | 2024-03-08T10:22:46Z |
| publishDate | 2016-03-01 |
| publisher | Luchevaya Diagnostika, LLC |
| record_format | Article |
| series | Вестник рентгенологии и радиологии |
| spelling | doaj.art-7e087cc7abbd4bf3a5461f5328d4a6772024-01-27T18:38:32ZengLuchevaya Diagnostika, LLCВестник рентгенологии и радиологии0042-46762619-04782016-03-0103465110.20862/0042-4676-2015-0-3-46-5169Pulmonary cytotoxicity induced by bleomycin and methotrexateZh, V, Sheykh0A. O. Krutskevich1N. S. Drebushevskiy2S. N. Shvayko3A. P. Dunaev4V. G. Alekseev5S.P. Botkin City Clinical Hospital, Moscow City Health DepartmentA.I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency of RussiaA.I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency of RussiaS.P. Botkin City Clinical Hospital, Moscow City Health DepartmentA.I. Burnazyan Federal Medical Biophysical Center, Federal Medical-Biological Agency of RussiaS.P. Botkin City Clinical Hospital, Moscow City Health DepartmentEarly detection of drug-induced pulmonary parenchymal injuries is often hampered by nonspecific clinical and X-ray manifestations. The diagnosis is usually based on a history of drug use, clinical and X-ray presentation, and exclusion of other causes of lung tissue injury.Chemical preparations most commonly cause pathological pulmonary changes. Overall, about 10% of all patients receiving chemotherapy develop pathological changes in the lung parenchyma. The main chemical preparations causing lung injury are bleomycin, methotrexate, carmustine, busulfan, and cyclophosphamide.Out of all examination techniques, computed tomography is most sensitive in determining the presence, specific features, and trends in the development of drug-induced pulmonary parenchymaldisease.The paper gives the data available in the literature and 2 clinical observations of pulmonary parenchymal disease induced by bleomycin and methotrexate.https://www.russianradiology.ru/jour/article/view/69pulmonary cytotoxicitychemotherapybleomycinmethotrexatepulmonary fibrosis |
| spellingShingle | Zh, V, Sheykh A. O. Krutskevich N. S. Drebushevskiy S. N. Shvayko A. P. Dunaev V. G. Alekseev Pulmonary cytotoxicity induced by bleomycin and methotrexate Вестник рентгенологии и радиологии pulmonary cytotoxicity chemotherapy bleomycin methotrexate pulmonary fibrosis |
| title | Pulmonary cytotoxicity induced by bleomycin and methotrexate |
| title_full | Pulmonary cytotoxicity induced by bleomycin and methotrexate |
| title_fullStr | Pulmonary cytotoxicity induced by bleomycin and methotrexate |
| title_full_unstemmed | Pulmonary cytotoxicity induced by bleomycin and methotrexate |
| title_short | Pulmonary cytotoxicity induced by bleomycin and methotrexate |
| title_sort | pulmonary cytotoxicity induced by bleomycin and methotrexate |
| topic | pulmonary cytotoxicity chemotherapy bleomycin methotrexate pulmonary fibrosis |
| url | https://www.russianradiology.ru/jour/article/view/69 |
| work_keys_str_mv | AT zhvsheykh pulmonarycytotoxicityinducedbybleomycinandmethotrexate AT aokrutskevich pulmonarycytotoxicityinducedbybleomycinandmethotrexate AT nsdrebushevskiy pulmonarycytotoxicityinducedbybleomycinandmethotrexate AT snshvayko pulmonarycytotoxicityinducedbybleomycinandmethotrexate AT apdunaev pulmonarycytotoxicityinducedbybleomycinandmethotrexate AT vgalekseev pulmonarycytotoxicityinducedbybleomycinandmethotrexate |