Even experts cannot agree on the optimal use of platelet-rich plasma in lateral elbow tendinopathy: an international Delphi study
Abstract Background Platelet-rich plasma (PRP) is widely used in the management of lateral elbow tendinopathy (LET) despite conflicting evidence on its effectiveness. With high levels of user experience, this study aimed to assess consensus amongst experts on its clinical use. Methods A three-round...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-11-01
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| Series: | Journal of Orthopaedics and Traumatology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s10195-021-00608-5 |
| _version_ | 1819280904733851648 |
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| author | Jonathan P. Evans Nicola Maffulli Chris Smith Adam Watts Jose Valderas Vicki Goodwin |
| author_facet | Jonathan P. Evans Nicola Maffulli Chris Smith Adam Watts Jose Valderas Vicki Goodwin |
| author_sort | Jonathan P. Evans |
| collection | DOAJ |
| description | Abstract Background Platelet-rich plasma (PRP) is widely used in the management of lateral elbow tendinopathy (LET) despite conflicting evidence on its effectiveness. With high levels of user experience, this study aimed to assess consensus amongst experts on its clinical use. Methods A three-round international Delphi study was conducted. Participants were invited through national society mailing lists and contact lists derived from a systematic search of the literature on PRP. In round one, a primary working group developed 40 statements on PRP preparation and clinical application. In rounds two and three, an international group of researchers on PRP and clinical users of the device scored their levels of agreement with the statements on a five-point scale. Consensus was defined as an interquartile range of ≤ 1. Results Consensus of agreement was only reached for 17/40 (42.5%) statements. For statements on PRP formulation, consensus of agreement was reached in 2/6 statements (33%). Only limited consensus on the contraindications, delivery strategy and delivery technique was achieved. Conclusion Experts reached very limited consensus on the use of PRP in LET. High levels of user experience have not resulted in a convergence of opinion on the technical components of PRP formulation and delivery, substantiating the need for further studies and improved trial reporting. |
| first_indexed | 2024-12-24T00:51:13Z |
| format | Article |
| id | doaj.art-7e08819dfaa44394908f539e01ecf166 |
| institution | Directory Open Access Journal |
| issn | 1590-9921 1590-9999 |
| language | English |
| last_indexed | 2024-12-24T00:51:13Z |
| publishDate | 2021-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of Orthopaedics and Traumatology |
| spelling | doaj.art-7e08819dfaa44394908f539e01ecf1662022-12-21T17:23:34ZengSpringerOpenJournal of Orthopaedics and Traumatology1590-99211590-99992021-11-0122111010.1186/s10195-021-00608-5Even experts cannot agree on the optimal use of platelet-rich plasma in lateral elbow tendinopathy: an international Delphi studyJonathan P. Evans0Nicola Maffulli1Chris Smith2Adam Watts3Jose Valderas4Vicki Goodwin5Royal Devon and Exeter NHS Foundation TrustDepartment of Musculoskeletal Disorders, University of SalernoRoyal Devon and Exeter NHS Foundation TrustWrightington Wigan and Leigh NHS Trust, Wrightington HospitalHealth Services and Policy Research Group, University of ExeterNational Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) South West Peninsula, University of Exeter Medical SchoolAbstract Background Platelet-rich plasma (PRP) is widely used in the management of lateral elbow tendinopathy (LET) despite conflicting evidence on its effectiveness. With high levels of user experience, this study aimed to assess consensus amongst experts on its clinical use. Methods A three-round international Delphi study was conducted. Participants were invited through national society mailing lists and contact lists derived from a systematic search of the literature on PRP. In round one, a primary working group developed 40 statements on PRP preparation and clinical application. In rounds two and three, an international group of researchers on PRP and clinical users of the device scored their levels of agreement with the statements on a five-point scale. Consensus was defined as an interquartile range of ≤ 1. Results Consensus of agreement was only reached for 17/40 (42.5%) statements. For statements on PRP formulation, consensus of agreement was reached in 2/6 statements (33%). Only limited consensus on the contraindications, delivery strategy and delivery technique was achieved. Conclusion Experts reached very limited consensus on the use of PRP in LET. High levels of user experience have not resulted in a convergence of opinion on the technical components of PRP formulation and delivery, substantiating the need for further studies and improved trial reporting.https://doi.org/10.1186/s10195-021-00608-5Platelet-rich plasmaPRPConsensusElbowTendinopathyTennis elbow |
| spellingShingle | Jonathan P. Evans Nicola Maffulli Chris Smith Adam Watts Jose Valderas Vicki Goodwin Even experts cannot agree on the optimal use of platelet-rich plasma in lateral elbow tendinopathy: an international Delphi study Journal of Orthopaedics and Traumatology Platelet-rich plasma PRP Consensus Elbow Tendinopathy Tennis elbow |
| title | Even experts cannot agree on the optimal use of platelet-rich plasma in lateral elbow tendinopathy: an international Delphi study |
| title_full | Even experts cannot agree on the optimal use of platelet-rich plasma in lateral elbow tendinopathy: an international Delphi study |
| title_fullStr | Even experts cannot agree on the optimal use of platelet-rich plasma in lateral elbow tendinopathy: an international Delphi study |
| title_full_unstemmed | Even experts cannot agree on the optimal use of platelet-rich plasma in lateral elbow tendinopathy: an international Delphi study |
| title_short | Even experts cannot agree on the optimal use of platelet-rich plasma in lateral elbow tendinopathy: an international Delphi study |
| title_sort | even experts cannot agree on the optimal use of platelet rich plasma in lateral elbow tendinopathy an international delphi study |
| topic | Platelet-rich plasma PRP Consensus Elbow Tendinopathy Tennis elbow |
| url | https://doi.org/10.1186/s10195-021-00608-5 |
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