Chronic Intermittent Ethanol Administration during Adolescence Produces Sex Dependent Impairments in Behavioral Flexibility and Survivability
Chronic intermittent ethanol exposure during adolescence produces behavioral impairments and neurobiological changes that can last into young adulthood. One such behavioral impairment is reduced behavioral flexibility, a behavioral impairment that has been correlated with the risk for increased etha...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/12/5/606 |
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| author | Douglas B. Matthews Samantha Scaletty Sarah Trapp Abigail Kastner Amelia M. Schneider Areonna Schreiber Gillian Rossmann |
| author_facet | Douglas B. Matthews Samantha Scaletty Sarah Trapp Abigail Kastner Amelia M. Schneider Areonna Schreiber Gillian Rossmann |
| author_sort | Douglas B. Matthews |
| collection | DOAJ |
| description | Chronic intermittent ethanol exposure during adolescence produces behavioral impairments and neurobiological changes that can last into young adulthood. One such behavioral impairment is reduced behavioral flexibility, a behavioral impairment that has been correlated with the risk for increased ethanol intake. In the current study, we investigated if chronic intermittent ethanol exposure during adolescence alters cognition, including behavioral flexibility, over a 22-month testing period. Female and male rats were treated with either 3.0 g/kg or 5.0 g/kg ethanol via gavage in a chronic intermittent fashion during adolescence and then tested every 4 to 5 months on a series of cognitive measures in the Morris water maze. Chronic intermittent ethanol selectively impaired behavioral flexibility in both female and male rats, although the pattern of results was different as a function of sex. In addition, female, but not male, rats were impaired in a short-term relearning test. Finally, male rats administered ethanol during adolescence were significantly more likely to not survive the 22-month experiment compared to female rats administered ethanol during adolescence. The current results demonstrate that adolescence is a unique period of development where chronic intermittent ethanol exposure produces long-lasting, selective cognitive impairments across the lifespan. |
| first_indexed | 2024-03-10T03:14:38Z |
| format | Article |
| id | doaj.art-7e088e360440438b8f6ecf23bd9215d3 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T03:14:38Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-7e088e360440438b8f6ecf23bd9215d32023-11-23T10:17:48ZengMDPI AGBrain Sciences2076-34252022-05-0112560610.3390/brainsci12050606Chronic Intermittent Ethanol Administration during Adolescence Produces Sex Dependent Impairments in Behavioral Flexibility and SurvivabilityDouglas B. Matthews0Samantha Scaletty1Sarah Trapp2Abigail Kastner3Amelia M. Schneider4Areonna Schreiber5Gillian Rossmann6Department of Psychology, University of Wisconsin—Eau Claire, Eau Claire, WI 54701, USADepartment of Psychology, University of Wisconsin—Eau Claire, Eau Claire, WI 54701, USADepartment of Psychology, University of Wisconsin—Eau Claire, Eau Claire, WI 54701, USADepartment of Psychology, University of Wisconsin—Eau Claire, Eau Claire, WI 54701, USADepartment of Psychology, University of Wisconsin—Eau Claire, Eau Claire, WI 54701, USADepartment of Psychology, University of Wisconsin—Eau Claire, Eau Claire, WI 54701, USADepartment of Psychology, University of Wisconsin—Eau Claire, Eau Claire, WI 54701, USAChronic intermittent ethanol exposure during adolescence produces behavioral impairments and neurobiological changes that can last into young adulthood. One such behavioral impairment is reduced behavioral flexibility, a behavioral impairment that has been correlated with the risk for increased ethanol intake. In the current study, we investigated if chronic intermittent ethanol exposure during adolescence alters cognition, including behavioral flexibility, over a 22-month testing period. Female and male rats were treated with either 3.0 g/kg or 5.0 g/kg ethanol via gavage in a chronic intermittent fashion during adolescence and then tested every 4 to 5 months on a series of cognitive measures in the Morris water maze. Chronic intermittent ethanol selectively impaired behavioral flexibility in both female and male rats, although the pattern of results was different as a function of sex. In addition, female, but not male, rats were impaired in a short-term relearning test. Finally, male rats administered ethanol during adolescence were significantly more likely to not survive the 22-month experiment compared to female rats administered ethanol during adolescence. The current results demonstrate that adolescence is a unique period of development where chronic intermittent ethanol exposure produces long-lasting, selective cognitive impairments across the lifespan.https://www.mdpi.com/2076-3425/12/5/606chronic intermittent ethanoladolescenceagedbehavioral flexibilitylearning |
| spellingShingle | Douglas B. Matthews Samantha Scaletty Sarah Trapp Abigail Kastner Amelia M. Schneider Areonna Schreiber Gillian Rossmann Chronic Intermittent Ethanol Administration during Adolescence Produces Sex Dependent Impairments in Behavioral Flexibility and Survivability Brain Sciences chronic intermittent ethanol adolescence aged behavioral flexibility learning |
| title | Chronic Intermittent Ethanol Administration during Adolescence Produces Sex Dependent Impairments in Behavioral Flexibility and Survivability |
| title_full | Chronic Intermittent Ethanol Administration during Adolescence Produces Sex Dependent Impairments in Behavioral Flexibility and Survivability |
| title_fullStr | Chronic Intermittent Ethanol Administration during Adolescence Produces Sex Dependent Impairments in Behavioral Flexibility and Survivability |
| title_full_unstemmed | Chronic Intermittent Ethanol Administration during Adolescence Produces Sex Dependent Impairments in Behavioral Flexibility and Survivability |
| title_short | Chronic Intermittent Ethanol Administration during Adolescence Produces Sex Dependent Impairments in Behavioral Flexibility and Survivability |
| title_sort | chronic intermittent ethanol administration during adolescence produces sex dependent impairments in behavioral flexibility and survivability |
| topic | chronic intermittent ethanol adolescence aged behavioral flexibility learning |
| url | https://www.mdpi.com/2076-3425/12/5/606 |
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