Non-Coding RNAs in Hereditary Kidney Disorders
Single-gene defects have been revealed to be the etiologies of many kidney diseases with the recent advances in molecular genetics. Autosomal dominant polycystic kidney disease (ADPKD), as one of the most common inherited kidney diseases, is caused by mutations of PKD1 or PKD2 gene. Due to the compl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/6/3014 |
| _version_ | 1797541188619730944 |
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| author | Julie Xia Zhou Xiaogang Li |
| author_facet | Julie Xia Zhou Xiaogang Li |
| author_sort | Julie Xia Zhou |
| collection | DOAJ |
| description | Single-gene defects have been revealed to be the etiologies of many kidney diseases with the recent advances in molecular genetics. Autosomal dominant polycystic kidney disease (ADPKD), as one of the most common inherited kidney diseases, is caused by mutations of PKD1 or PKD2 gene. Due to the complexity of pathophysiology of cyst formation and progression, limited therapeutic options are available. The roles of noncoding RNAs in development and disease have gained widespread attention in recent years. In particular, microRNAs in promoting PKD progression have been highlighted. The dysregulated microRNAs modulate cyst growth through suppressing the expression of PKD genes and regulating cystic renal epithelial cell proliferation, mitochondrial metabolism, apoptosis and autophagy. The antagonists of microRNAs have emerged as potential therapeutic drugs for the treatment of ADPKD. In addition, studies have also focused on microRNAs as potential biomarkers for ADPKD and other common hereditary kidney diseases, including HNF1β-associated kidney disease, Alport syndrome, congenital abnormalities of the kidney and urinary tract (CAKUT), von Hippel–Lindau (VHL) disease, and Fabry disease. This review assembles the current understanding of the non-coding RNAs, including microRNAs and long noncoding RNAs, in polycystic kidney disease and these common monogenic kidney diseases. |
| first_indexed | 2024-03-10T13:12:40Z |
| format | Article |
| id | doaj.art-7e09477e9bc3466bb1a17cfdacf7b64f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T13:12:40Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7e09477e9bc3466bb1a17cfdacf7b64f2023-11-21T10:40:06ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-03-01226301410.3390/ijms22063014Non-Coding RNAs in Hereditary Kidney DisordersJulie Xia Zhou0Xiaogang Li1Department of Internal Medicine, Advent Health, Orlando, FL 32804, USADepartment of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USASingle-gene defects have been revealed to be the etiologies of many kidney diseases with the recent advances in molecular genetics. Autosomal dominant polycystic kidney disease (ADPKD), as one of the most common inherited kidney diseases, is caused by mutations of PKD1 or PKD2 gene. Due to the complexity of pathophysiology of cyst formation and progression, limited therapeutic options are available. The roles of noncoding RNAs in development and disease have gained widespread attention in recent years. In particular, microRNAs in promoting PKD progression have been highlighted. The dysregulated microRNAs modulate cyst growth through suppressing the expression of PKD genes and regulating cystic renal epithelial cell proliferation, mitochondrial metabolism, apoptosis and autophagy. The antagonists of microRNAs have emerged as potential therapeutic drugs for the treatment of ADPKD. In addition, studies have also focused on microRNAs as potential biomarkers for ADPKD and other common hereditary kidney diseases, including HNF1β-associated kidney disease, Alport syndrome, congenital abnormalities of the kidney and urinary tract (CAKUT), von Hippel–Lindau (VHL) disease, and Fabry disease. This review assembles the current understanding of the non-coding RNAs, including microRNAs and long noncoding RNAs, in polycystic kidney disease and these common monogenic kidney diseases.https://www.mdpi.com/1422-0067/22/6/3014non-coding RNAmicroRNAGenetic kidney diseasePKD |
| spellingShingle | Julie Xia Zhou Xiaogang Li Non-Coding RNAs in Hereditary Kidney Disorders International Journal of Molecular Sciences non-coding RNA microRNA Genetic kidney disease PKD |
| title | Non-Coding RNAs in Hereditary Kidney Disorders |
| title_full | Non-Coding RNAs in Hereditary Kidney Disorders |
| title_fullStr | Non-Coding RNAs in Hereditary Kidney Disorders |
| title_full_unstemmed | Non-Coding RNAs in Hereditary Kidney Disorders |
| title_short | Non-Coding RNAs in Hereditary Kidney Disorders |
| title_sort | non coding rnas in hereditary kidney disorders |
| topic | non-coding RNA microRNA Genetic kidney disease PKD |
| url | https://www.mdpi.com/1422-0067/22/6/3014 |
| work_keys_str_mv | AT juliexiazhou noncodingrnasinhereditarykidneydisorders AT xiaogangli noncodingrnasinhereditarykidneydisorders |