Challenges in diagnostic testing of nephritic factors
Nephritic factors (NeFs) are autoantibodies promoting the activity of the central enzymes of the complement cascade, an important first line of defense of our innate immune system. NeFs stabilize the complement convertase complexes and prevent their natural and regulator-mediated decay. They are mos...
Main Authors: | Marloes A. H. M. Michels, Elena B. Volokhina, Nicole C. A. J. van de Kar, Lambertus P.W. J. van den Heuvel |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-11-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1036136/full |
Similar Items
-
Novel Assays to Distinguish Between Properdin-Dependent and Properdin-Independent C3 Nephritic Factors Provide Insight Into Properdin-Inhibiting Therapy
by: Marloes A. H. M. Michels, et al.
Published: (2019-06-01) -
Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases
by: Marloes A. H. M. Michels, et al.
Published: (2018-04-01) -
Different Aspects of Classical Pathway Overactivation in Patients With C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative Glomerulonephritis
by: Marloes A. H. M. Michels, et al.
Published: (2021-08-01) -
Functional evaluation of complement factor I variants by immunoassays and SDS-PAGE
by: Alexandra Gerogianni, et al.
Published: (2023-10-01) -
Gain of function mutant of complement factor B K323E mimics pathogenic C3NeF autoantibodies in convertase assays
by: Aleksandra Urban, et al.
Published: (2018-01-01)