The Metalloprotease, Mpr1, Engages AnnexinA2 to Promote the Transcytosis of Fungal Cells across the Blood-Brain Barrier

The Metalloprotease, Mpr1, Engages AnnexinA2 to Promote the Transcytosis of Fungal Cells across the Blood-Brain Barrier

Eukaryotic pathogens display multiple mechanisms for breaching the blood-brain barrier (BBB) and invading the central nervous system (CNS). Of the fungal spp., that cause disease in mammals, only some cross brain microvascular endothelial cells which constitute the BBB, and invade the brain. Cryptoc...

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Bibliographic Details
Main Authors: Sarisa Na Pombejra, Michelle Salemi, Brett S. Phinney, Angie Gelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
AnnexinA2
Mpr1
metalloprotease
blood-brain barrier
fungal cells
Saccharomyces cerevisiae
Online Access:http://journal.frontiersin.org/article/10.3389/fcimb.2017.00296/full

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