The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation
Here, we review the role of oxidative protein modification as a signal for recognition and degradation of proteins. It was clearly demonstrated that the ATP- and ubiquitin-independent 20S proteasome is playing a key role in the selective removal of oxidized proteins. Furthermore, the current knowled...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-01-01
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| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231713000967 |
| _version_ | 1831613870779662336 |
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| author | Tobias Jung Annika Höhn Tilman Grune |
| author_facet | Tobias Jung Annika Höhn Tilman Grune |
| author_sort | Tobias Jung |
| collection | DOAJ |
| description | Here, we review the role of oxidative protein modification as a signal for recognition and degradation of proteins. It was clearly demonstrated that the ATP- and ubiquitin-independent 20S proteasome is playing a key role in the selective removal of oxidized proteins. Furthermore, the current knowledge of the substrate susceptibility on the degradation of oxidized proteins and the role of the immunoproteasome will be highlighted. |
| first_indexed | 2024-12-18T19:17:00Z |
| format | Article |
| id | doaj.art-7e0a9bffb746436dabe97c4c24967217 |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-12-18T19:17:00Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-7e0a9bffb746436dabe97c4c249672172022-12-21T20:56:06ZengElsevierRedox Biology2213-23172014-01-012C9910410.1016/j.redox.2013.12.008The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradationTobias JungAnnika HöhnTilman GruneHere, we review the role of oxidative protein modification as a signal for recognition and degradation of proteins. It was clearly demonstrated that the ATP- and ubiquitin-independent 20S proteasome is playing a key role in the selective removal of oxidized proteins. Furthermore, the current knowledge of the substrate susceptibility on the degradation of oxidized proteins and the role of the immunoproteasome will be highlighted.http://www.sciencedirect.com/science/article/pii/S221323171300096720S ProteasomeProtein oxidationImmunoproteasomeProtein aggregates |
| spellingShingle | Tobias Jung Annika Höhn Tilman Grune The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation Redox Biology 20S Proteasome Protein oxidation Immunoproteasome Protein aggregates |
| title | The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation |
| title_full | The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation |
| title_fullStr | The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation |
| title_full_unstemmed | The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation |
| title_short | The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation |
| title_sort | proteasome and the degradation of oxidized proteins part ii protein oxidation and proteasomal degradation |
| topic | 20S Proteasome Protein oxidation Immunoproteasome Protein aggregates |
| url | http://www.sciencedirect.com/science/article/pii/S2213231713000967 |
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