Reduction of c-Fos via Overexpression of miR-34a Results in Enhancement of TNF- Production by LPS in Neutrophils from Myelodysplastic Syndrome Patients.
Although increased TNF-α has been considered to cause ineffective hematopoiesis in myelodysplastic syndromes (MDS), the mechanisms of TNF-α elevation are not known. We recently found that c-Fos mRNA stabilization under translation-inhibiting stimuli was impaired in MDS-derived neutrophilic granulocy...
Main Authors: | Yayoi Shikama, Meiwan Cao, Tomoyuki Ono, Xiaomin Feng, Hideyoshi Noji, Hideo Kimura, Kazuei Ogawa, Yuko Suzuki, Kazuhiko Ikeda, Yasuchika Takeishi, Junko Kimura |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2016-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4981319?pdf=render |
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