Rare case of iatrogenic immunodeficiency associated lymphoproliferative disorder with superimposed infection causing airway obstruction requiring emergent tracheostomy
Methotrexate is an immunomodulator used as first line treatment for patients with rheumatoid arthritis and has a well-recognized association with other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OIIA-LPD). OIIA-LPD and its association with methotrexate has been discussed i...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-11-01
|
| Series: | Otolaryngology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468548821000746 |
| _version_ | 1818402597644533760 |
|---|---|
| author | Natalie Derise, MD Anatoli Karas, MD Ryan Marshall, MD Nicholas Smith, MD |
| author_facet | Natalie Derise, MD Anatoli Karas, MD Ryan Marshall, MD Nicholas Smith, MD |
| author_sort | Natalie Derise, MD |
| collection | DOAJ |
| description | Methotrexate is an immunomodulator used as first line treatment for patients with rheumatoid arthritis and has a well-recognized association with other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OIIA-LPD). OIIA-LPD and its association with methotrexate has been discussed in the literature but is rarely seen in the pediatric population. Additionally, there are no prior reports showing an association between IIA-LPD and bacterial superinfection. We present a case of airway compromise requiring emergent tracheostomy in a 15-year-old patient secondary to superimposed infection in the setting of lymphoproliferative disorder. To our knowledge, this is the first case of OIIA-LPD causing airway compromise requiring emergent tracheostomy. |
| first_indexed | 2024-12-14T08:10:54Z |
| format | Article |
| id | doaj.art-7e0b4a69695444298526d9a627480960 |
| institution | Directory Open Access Journal |
| issn | 2468-5488 |
| language | English |
| last_indexed | 2024-12-14T08:10:54Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Otolaryngology Case Reports |
| spelling | doaj.art-7e0b4a69695444298526d9a6274809602022-12-21T23:10:04ZengElsevierOtolaryngology Case Reports2468-54882021-11-0121100333Rare case of iatrogenic immunodeficiency associated lymphoproliferative disorder with superimposed infection causing airway obstruction requiring emergent tracheostomyNatalie Derise, MD0Anatoli Karas, MD1Ryan Marshall, MD2Nicholas Smith, MD3University of Alabama at Birmingham Department of Otolaryngology Head and Neck Surgery, FOT 1155, 1720 2nd Avenue, South Birmingham, AL, 35294-3412, USA; Corresponding author. FOT 1155, 1720 2nd Avenue South Birmingham, AL, 35294-3412, USA.University of Alabama at Birmingham Children's of Alabama Department of Otolaryngology, FOT 1155, 1720 2nd Avenue, South Birmingham, AL, 35294-3412, USAUniversity of Alabama at Birmingham Department of Otolaryngology Head and Neck Surgery, FOT 1155, 1720 2nd Avenue, South Birmingham, AL, 35294-3412, USAUniversity of Alabama at Birmingham Children's of Alabama Department of Otolaryngology, FOT 1155, 1720 2nd Avenue, South Birmingham, AL, 35294-3412, USAMethotrexate is an immunomodulator used as first line treatment for patients with rheumatoid arthritis and has a well-recognized association with other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OIIA-LPD). OIIA-LPD and its association with methotrexate has been discussed in the literature but is rarely seen in the pediatric population. Additionally, there are no prior reports showing an association between IIA-LPD and bacterial superinfection. We present a case of airway compromise requiring emergent tracheostomy in a 15-year-old patient secondary to superimposed infection in the setting of lymphoproliferative disorder. To our knowledge, this is the first case of OIIA-LPD causing airway compromise requiring emergent tracheostomy.http://www.sciencedirect.com/science/article/pii/S2468548821000746Emergent tracheostomyAirway compromiseLymphoproliferative disordersEpstein-Barr virus (EBV)MethotrexateInfliximab |
| spellingShingle | Natalie Derise, MD Anatoli Karas, MD Ryan Marshall, MD Nicholas Smith, MD Rare case of iatrogenic immunodeficiency associated lymphoproliferative disorder with superimposed infection causing airway obstruction requiring emergent tracheostomy Otolaryngology Case Reports Emergent tracheostomy Airway compromise Lymphoproliferative disorders Epstein-Barr virus (EBV) Methotrexate Infliximab |
| title | Rare case of iatrogenic immunodeficiency associated lymphoproliferative disorder with superimposed infection causing airway obstruction requiring emergent tracheostomy |
| title_full | Rare case of iatrogenic immunodeficiency associated lymphoproliferative disorder with superimposed infection causing airway obstruction requiring emergent tracheostomy |
| title_fullStr | Rare case of iatrogenic immunodeficiency associated lymphoproliferative disorder with superimposed infection causing airway obstruction requiring emergent tracheostomy |
| title_full_unstemmed | Rare case of iatrogenic immunodeficiency associated lymphoproliferative disorder with superimposed infection causing airway obstruction requiring emergent tracheostomy |
| title_short | Rare case of iatrogenic immunodeficiency associated lymphoproliferative disorder with superimposed infection causing airway obstruction requiring emergent tracheostomy |
| title_sort | rare case of iatrogenic immunodeficiency associated lymphoproliferative disorder with superimposed infection causing airway obstruction requiring emergent tracheostomy |
| topic | Emergent tracheostomy Airway compromise Lymphoproliferative disorders Epstein-Barr virus (EBV) Methotrexate Infliximab |
| url | http://www.sciencedirect.com/science/article/pii/S2468548821000746 |
| work_keys_str_mv | AT nataliederisemd rarecaseofiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderwithsuperimposedinfectioncausingairwayobstructionrequiringemergenttracheostomy AT anatolikarasmd rarecaseofiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderwithsuperimposedinfectioncausingairwayobstructionrequiringemergenttracheostomy AT ryanmarshallmd rarecaseofiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderwithsuperimposedinfectioncausingairwayobstructionrequiringemergenttracheostomy AT nicholassmithmd rarecaseofiatrogenicimmunodeficiencyassociatedlymphoproliferativedisorderwithsuperimposedinfectioncausingairwayobstructionrequiringemergenttracheostomy |