Trafficking of ThermoTRP Channels
ThermoTRP channels (thermoTRPs) define a subfamily of the transient receptor potential (TRP) channels that are activated by changes in the environmental temperature, from noxious cold to injurious heat. Acting as integrators of several stimuli and signalling pathways, dysfunction of these channels c...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-08-01
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| Series: | Membranes |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2077-0375/4/3/525 |
| _version_ | 1797714312898281472 |
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| author | Clotilde Ferrandiz-Huertas Sakthikumar Mathivanan Christoph Jakob Wolf Isabel Devesa Antonio Ferrer-Montiel |
| author_facet | Clotilde Ferrandiz-Huertas Sakthikumar Mathivanan Christoph Jakob Wolf Isabel Devesa Antonio Ferrer-Montiel |
| author_sort | Clotilde Ferrandiz-Huertas |
| collection | DOAJ |
| description | ThermoTRP channels (thermoTRPs) define a subfamily of the transient receptor potential (TRP) channels that are activated by changes in the environmental temperature, from noxious cold to injurious heat. Acting as integrators of several stimuli and signalling pathways, dysfunction of these channels contributes to several pathological states. The surface expression of thermoTRPs is controlled by both, the constitutive and regulated vesicular trafficking. Modulation of receptor surface density during pathological processes is nowadays considered as an interesting therapeutic approach for management of diseases, such as chronic pain, in which an increased trafficking is associated with the pathological state. This review will focus on the recent advances trafficking of the thermoTRP channels, TRPV1, TRPV2, TRPV4, TRPM3, TRPM8 and TRPA1, into/from the plasma membrane. Particularly, regulated membrane insertion of thermoTRPs channels contributes to a fine tuning of final channel activity, and indeed, it has resulted in the development of novel therapeutic approaches with successful clinical results such as disruption of SNARE-dependent exocytosis by botulinum toxin or botulinomimetic peptides. |
| first_indexed | 2024-03-12T07:49:54Z |
| format | Article |
| id | doaj.art-7e0b5fa544104c59b7425095e6e3d8da |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-12T07:49:54Z |
| publishDate | 2014-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-7e0b5fa544104c59b7425095e6e3d8da2023-09-02T20:41:38ZengMDPI AGMembranes2077-03752014-08-014352556410.3390/membranes4030525membranes4030525Trafficking of ThermoTRP ChannelsClotilde Ferrandiz-Huertas0Sakthikumar Mathivanan1Christoph Jakob Wolf2Isabel Devesa3Antonio Ferrer-Montiel4Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante 03202, SpainInstituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante 03202, SpainInstituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante 03202, SpainInstituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante 03202, SpainInstituto de Biología Molecular y Celular, Universidad Miguel Hernández, Alicante 03202, SpainThermoTRP channels (thermoTRPs) define a subfamily of the transient receptor potential (TRP) channels that are activated by changes in the environmental temperature, from noxious cold to injurious heat. Acting as integrators of several stimuli and signalling pathways, dysfunction of these channels contributes to several pathological states. The surface expression of thermoTRPs is controlled by both, the constitutive and regulated vesicular trafficking. Modulation of receptor surface density during pathological processes is nowadays considered as an interesting therapeutic approach for management of diseases, such as chronic pain, in which an increased trafficking is associated with the pathological state. This review will focus on the recent advances trafficking of the thermoTRP channels, TRPV1, TRPV2, TRPV4, TRPM3, TRPM8 and TRPA1, into/from the plasma membrane. Particularly, regulated membrane insertion of thermoTRPs channels contributes to a fine tuning of final channel activity, and indeed, it has resulted in the development of novel therapeutic approaches with successful clinical results such as disruption of SNARE-dependent exocytosis by botulinum toxin or botulinomimetic peptides.http://www.mdpi.com/2077-0375/4/3/525TRPthermoTRPexocytosisSNAREprotein-protein |
| spellingShingle | Clotilde Ferrandiz-Huertas Sakthikumar Mathivanan Christoph Jakob Wolf Isabel Devesa Antonio Ferrer-Montiel Trafficking of ThermoTRP Channels Membranes TRP thermoTRP exocytosis SNARE protein-protein |
| title | Trafficking of ThermoTRP Channels |
| title_full | Trafficking of ThermoTRP Channels |
| title_fullStr | Trafficking of ThermoTRP Channels |
| title_full_unstemmed | Trafficking of ThermoTRP Channels |
| title_short | Trafficking of ThermoTRP Channels |
| title_sort | trafficking of thermotrp channels |
| topic | TRP thermoTRP exocytosis SNARE protein-protein |
| url | http://www.mdpi.com/2077-0375/4/3/525 |
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