Glycerol Monolaurate Microbicide Protection against Repeat High-Dose SIV Vaginal Challenge.
Measures to prevent sexual mucosal transmission are critically needed, particularly to prevent transmission to young women at high risk in the microepidemics in South Africa that disproportionally contribute to the continued pandemic. To that end, microbicides containing anti-retroviral (ARV) agents...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4461171?pdf=render |
| _version_ | 1818452954073530368 |
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| author | Ashley T Haase Eva Rakasz Nancy Schultz-Darken Karla Nephew Kimberly L Weisgrau Cavan S Reilly Qingsheng Li Peter J Southern Meghan Rothenberger Marnie L Peterson Patrick M Schlievert |
| author_facet | Ashley T Haase Eva Rakasz Nancy Schultz-Darken Karla Nephew Kimberly L Weisgrau Cavan S Reilly Qingsheng Li Peter J Southern Meghan Rothenberger Marnie L Peterson Patrick M Schlievert |
| author_sort | Ashley T Haase |
| collection | DOAJ |
| description | Measures to prevent sexual mucosal transmission are critically needed, particularly to prevent transmission to young women at high risk in the microepidemics in South Africa that disproportionally contribute to the continued pandemic. To that end, microbicides containing anti-retroviral (ARV) agents have been shown to prevent transmission, but with efficacy limited both by adherence and pre-existing innate immune and inflammatory conditions in the female reproductive tract (FRT). Glycerol monolaurate (GML) has been proposed as a microbicide component to enhance efficacy by blocking these transmission-facilitating innate immune response to vaginal exposure. We show here in an especially rigorous test of protection in the SIV-rhesus macaque model of HIV-1 transmission to women, that GML used daily and before vaginal challenge protects against repeat high doses of SIV by criteria that include virological and immunological assays to detect occult infection. We also provide evidence for indirect mechanisms of action in GML-mediated protection. Developing a sustained formulation for GML delivery could contribute an independent, complementary protective component to an ARV-containing microbicide. |
| first_indexed | 2024-12-14T21:31:17Z |
| format | Article |
| id | doaj.art-7e0b79000f3341749745d879aafb2ca1 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T21:31:17Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-7e0b79000f3341749745d879aafb2ca12022-12-21T22:46:41ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e012946510.1371/journal.pone.0129465Glycerol Monolaurate Microbicide Protection against Repeat High-Dose SIV Vaginal Challenge.Ashley T HaaseEva RakaszNancy Schultz-DarkenKarla NephewKimberly L WeisgrauCavan S ReillyQingsheng LiPeter J SouthernMeghan RothenbergerMarnie L PetersonPatrick M SchlievertMeasures to prevent sexual mucosal transmission are critically needed, particularly to prevent transmission to young women at high risk in the microepidemics in South Africa that disproportionally contribute to the continued pandemic. To that end, microbicides containing anti-retroviral (ARV) agents have been shown to prevent transmission, but with efficacy limited both by adherence and pre-existing innate immune and inflammatory conditions in the female reproductive tract (FRT). Glycerol monolaurate (GML) has been proposed as a microbicide component to enhance efficacy by blocking these transmission-facilitating innate immune response to vaginal exposure. We show here in an especially rigorous test of protection in the SIV-rhesus macaque model of HIV-1 transmission to women, that GML used daily and before vaginal challenge protects against repeat high doses of SIV by criteria that include virological and immunological assays to detect occult infection. We also provide evidence for indirect mechanisms of action in GML-mediated protection. Developing a sustained formulation for GML delivery could contribute an independent, complementary protective component to an ARV-containing microbicide.http://europepmc.org/articles/PMC4461171?pdf=render |
| spellingShingle | Ashley T Haase Eva Rakasz Nancy Schultz-Darken Karla Nephew Kimberly L Weisgrau Cavan S Reilly Qingsheng Li Peter J Southern Meghan Rothenberger Marnie L Peterson Patrick M Schlievert Glycerol Monolaurate Microbicide Protection against Repeat High-Dose SIV Vaginal Challenge. PLoS ONE |
| title | Glycerol Monolaurate Microbicide Protection against Repeat High-Dose SIV Vaginal Challenge. |
| title_full | Glycerol Monolaurate Microbicide Protection against Repeat High-Dose SIV Vaginal Challenge. |
| title_fullStr | Glycerol Monolaurate Microbicide Protection against Repeat High-Dose SIV Vaginal Challenge. |
| title_full_unstemmed | Glycerol Monolaurate Microbicide Protection against Repeat High-Dose SIV Vaginal Challenge. |
| title_short | Glycerol Monolaurate Microbicide Protection against Repeat High-Dose SIV Vaginal Challenge. |
| title_sort | glycerol monolaurate microbicide protection against repeat high dose siv vaginal challenge |
| url | http://europepmc.org/articles/PMC4461171?pdf=render |
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