Breast cancer in patients with germline TP53 pathogenic variants have typical tumour characteristics: the Cohort study of TP53 carrier early onset breast cancer (COPE study)

Breast cancer in patients with germline TP53 pathogenic variants have typical tumour characteristics: the Cohort study of TP53 carrier early onset breast cancer (COPE study)

Abstract Germline TP53 pathogenic variants are rare but associated with a high risk of cancer; they are often identified in the context of clinically diagnosed Li–Fraumeni syndrome predisposing to a range of young onset cancers including sarcomas and breast cancer. The study aim was to conduct a det...

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Bibliographic Details
Main Authors: Kate Packwood, Guy Martland, Matthew Sommerlad, Emily Shaw, Karwan Moutasim, Gareth Thomas, Adrian C Bateman, Louise Jones, Linda Haywood, D Gareth Evans, Jillian M Birch, Ohud A Alsalmi, Alex Henderson, Nicola Poplawski, Diana M Eccles
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:The Journal of Pathology: Clinical Research
Subjects:
breast cancer
TP53 pathogenic variant
germline
stroma
Online Access:https://doi.org/10.1002/cjp2.133

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