The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents
Coronary artery disease (CAD) is the leading killer of humans worldwide. Bioresorbable polymeric stents have attracted a great deal of interest because they can treat CAD without producing long-term complications. Bioresorbable polymeric stents (BMSs) have undergone a sustainable revolution in terms...
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MDPI AG
2021-08-01
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Online Access: | https://www.mdpi.com/2072-666X/12/8/990 |
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author | Liang Wang Li Jiao Shuoshuo Pang Pei Yan Xibin Wang Tianyang Qiu |
author_facet | Liang Wang Li Jiao Shuoshuo Pang Pei Yan Xibin Wang Tianyang Qiu |
author_sort | Liang Wang |
collection | DOAJ |
description | Coronary artery disease (CAD) is the leading killer of humans worldwide. Bioresorbable polymeric stents have attracted a great deal of interest because they can treat CAD without producing long-term complications. Bioresorbable polymeric stents (BMSs) have undergone a sustainable revolution in terms of material processing, mechanical performance, biodegradability and manufacture techniques. Biodegradable polymers and copolymers have been widely studied as potential material candidates for bioresorbable stents. It is a great challenge to find a reasonable balance between the mechanical properties and degradation behavior of bioresorbable polymeric stents. Surface modification and drug-coating methods are generally used to improve biocompatibility and drug loading performance, which are decisive factors for the safety and efficacy of bioresorbable stents. Traditional stent manufacture techniques include etching, micro-electro discharge machining, electroforming, die-casting and laser cutting. The rapid development of 3D printing has brought continuous innovation and the wide application of biodegradable materials, which provides a novel technique for the additive manufacture of bioresorbable stents. This review aims to describe the problems regarding and the achievements of biodegradable stents from their birth to the present and discuss potential difficulties and challenges in the future. |
first_indexed | 2024-03-10T08:35:14Z |
format | Article |
id | doaj.art-7e0fe987bb5442f4921e1fdece0768fa |
institution | Directory Open Access Journal |
issn | 2072-666X |
language | English |
last_indexed | 2024-03-10T08:35:14Z |
publishDate | 2021-08-01 |
publisher | MDPI AG |
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series | Micromachines |
spelling | doaj.art-7e0fe987bb5442f4921e1fdece0768fa2023-11-22T08:45:07ZengMDPI AGMicromachines2072-666X2021-08-0112899010.3390/mi12080990The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery StentsLiang Wang0Li Jiao1Shuoshuo Pang2Pei Yan3Xibin Wang4Tianyang Qiu5School of Mechanical Engineering, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, ChinaKey Laboratory of Fundamental Science for Advanced Machining Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, ChinaSchool of Mechanical Engineering, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, ChinaKey Laboratory of Fundamental Science for Advanced Machining Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, ChinaKey Laboratory of Fundamental Science for Advanced Machining Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, ChinaKey Laboratory of Fundamental Science for Advanced Machining Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, ChinaCoronary artery disease (CAD) is the leading killer of humans worldwide. Bioresorbable polymeric stents have attracted a great deal of interest because they can treat CAD without producing long-term complications. Bioresorbable polymeric stents (BMSs) have undergone a sustainable revolution in terms of material processing, mechanical performance, biodegradability and manufacture techniques. Biodegradable polymers and copolymers have been widely studied as potential material candidates for bioresorbable stents. It is a great challenge to find a reasonable balance between the mechanical properties and degradation behavior of bioresorbable polymeric stents. Surface modification and drug-coating methods are generally used to improve biocompatibility and drug loading performance, which are decisive factors for the safety and efficacy of bioresorbable stents. Traditional stent manufacture techniques include etching, micro-electro discharge machining, electroforming, die-casting and laser cutting. The rapid development of 3D printing has brought continuous innovation and the wide application of biodegradable materials, which provides a novel technique for the additive manufacture of bioresorbable stents. This review aims to describe the problems regarding and the achievements of biodegradable stents from their birth to the present and discuss potential difficulties and challenges in the future.https://www.mdpi.com/2072-666X/12/8/990bioresorbable stentmechanical propertydegradation behaviorbiocompatibilitymanufacture technique |
spellingShingle | Liang Wang Li Jiao Shuoshuo Pang Pei Yan Xibin Wang Tianyang Qiu The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents Micromachines bioresorbable stent mechanical property degradation behavior biocompatibility manufacture technique |
title | The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents |
title_full | The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents |
title_fullStr | The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents |
title_full_unstemmed | The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents |
title_short | The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents |
title_sort | development of design and manufacture techniques for bioresorbable coronary artery stents |
topic | bioresorbable stent mechanical property degradation behavior biocompatibility manufacture technique |
url | https://www.mdpi.com/2072-666X/12/8/990 |
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