The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents

Coronary artery disease (CAD) is the leading killer of humans worldwide. Bioresorbable polymeric stents have attracted a great deal of interest because they can treat CAD without producing long-term complications. Bioresorbable polymeric stents (BMSs) have undergone a sustainable revolution in terms...

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Main Authors: Liang Wang, Li Jiao, Shuoshuo Pang, Pei Yan, Xibin Wang, Tianyang Qiu
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Micromachines
Subjects:
Online Access:https://www.mdpi.com/2072-666X/12/8/990
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author Liang Wang
Li Jiao
Shuoshuo Pang
Pei Yan
Xibin Wang
Tianyang Qiu
author_facet Liang Wang
Li Jiao
Shuoshuo Pang
Pei Yan
Xibin Wang
Tianyang Qiu
author_sort Liang Wang
collection DOAJ
description Coronary artery disease (CAD) is the leading killer of humans worldwide. Bioresorbable polymeric stents have attracted a great deal of interest because they can treat CAD without producing long-term complications. Bioresorbable polymeric stents (BMSs) have undergone a sustainable revolution in terms of material processing, mechanical performance, biodegradability and manufacture techniques. Biodegradable polymers and copolymers have been widely studied as potential material candidates for bioresorbable stents. It is a great challenge to find a reasonable balance between the mechanical properties and degradation behavior of bioresorbable polymeric stents. Surface modification and drug-coating methods are generally used to improve biocompatibility and drug loading performance, which are decisive factors for the safety and efficacy of bioresorbable stents. Traditional stent manufacture techniques include etching, micro-electro discharge machining, electroforming, die-casting and laser cutting. The rapid development of 3D printing has brought continuous innovation and the wide application of biodegradable materials, which provides a novel technique for the additive manufacture of bioresorbable stents. This review aims to describe the problems regarding and the achievements of biodegradable stents from their birth to the present and discuss potential difficulties and challenges in the future.
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spelling doaj.art-7e0fe987bb5442f4921e1fdece0768fa2023-11-22T08:45:07ZengMDPI AGMicromachines2072-666X2021-08-0112899010.3390/mi12080990The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery StentsLiang Wang0Li Jiao1Shuoshuo Pang2Pei Yan3Xibin Wang4Tianyang Qiu5School of Mechanical Engineering, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, ChinaKey Laboratory of Fundamental Science for Advanced Machining Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, ChinaSchool of Mechanical Engineering, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, ChinaKey Laboratory of Fundamental Science for Advanced Machining Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, ChinaKey Laboratory of Fundamental Science for Advanced Machining Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, ChinaKey Laboratory of Fundamental Science for Advanced Machining Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, ChinaCoronary artery disease (CAD) is the leading killer of humans worldwide. Bioresorbable polymeric stents have attracted a great deal of interest because they can treat CAD without producing long-term complications. Bioresorbable polymeric stents (BMSs) have undergone a sustainable revolution in terms of material processing, mechanical performance, biodegradability and manufacture techniques. Biodegradable polymers and copolymers have been widely studied as potential material candidates for bioresorbable stents. It is a great challenge to find a reasonable balance between the mechanical properties and degradation behavior of bioresorbable polymeric stents. Surface modification and drug-coating methods are generally used to improve biocompatibility and drug loading performance, which are decisive factors for the safety and efficacy of bioresorbable stents. Traditional stent manufacture techniques include etching, micro-electro discharge machining, electroforming, die-casting and laser cutting. The rapid development of 3D printing has brought continuous innovation and the wide application of biodegradable materials, which provides a novel technique for the additive manufacture of bioresorbable stents. This review aims to describe the problems regarding and the achievements of biodegradable stents from their birth to the present and discuss potential difficulties and challenges in the future.https://www.mdpi.com/2072-666X/12/8/990bioresorbable stentmechanical propertydegradation behaviorbiocompatibilitymanufacture technique
spellingShingle Liang Wang
Li Jiao
Shuoshuo Pang
Pei Yan
Xibin Wang
Tianyang Qiu
The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents
Micromachines
bioresorbable stent
mechanical property
degradation behavior
biocompatibility
manufacture technique
title The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents
title_full The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents
title_fullStr The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents
title_full_unstemmed The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents
title_short The Development of Design and Manufacture Techniques for Bioresorbable Coronary Artery Stents
title_sort development of design and manufacture techniques for bioresorbable coronary artery stents
topic bioresorbable stent
mechanical property
degradation behavior
biocompatibility
manufacture technique
url https://www.mdpi.com/2072-666X/12/8/990
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