Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense Response
The human response to invading fungi includes a series of events that detect, kill, or clear the fungi. If the metabolic host response is unable to eliminate the fungi, an infection ensues. Some of the host response’s metabolic events to fungi can be imaged with molecules labelled with radionuclides...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Journal of Fungi |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2309-608X/7/6/407 |
| _version_ | 1797533073858887680 |
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| author | Alfred O. Ankrah Mike M. Sathekge Rudi A. J. O. Dierckx Andor W. J. M. Glaudemans |
| author_facet | Alfred O. Ankrah Mike M. Sathekge Rudi A. J. O. Dierckx Andor W. J. M. Glaudemans |
| author_sort | Alfred O. Ankrah |
| collection | DOAJ |
| description | The human response to invading fungi includes a series of events that detect, kill, or clear the fungi. If the metabolic host response is unable to eliminate the fungi, an infection ensues. Some of the host response’s metabolic events to fungi can be imaged with molecules labelled with radionuclides. Several important clinical applications have been found with radiolabelled biomolecules of inflammation. <sup>18</sup>F-fluorodeoxyglucose is the tracer that has been most widely investigated in the host defence of fungi. This tracer has added value in the early detection of infection, in staging and visualising dissemination of infection, and in monitoring antifungal treatment. Radiolabelled antimicrobial peptides showed promising results, but large prospective studies in fungal infection are lacking. Other tracers have also been used in imaging events of the host response, such as the migration of white blood cells at sites of infection, nutritional immunity in iron metabolism, and radiolabelled monoclonal antibodies. Many tracers are still at the preclinical stage. Some tracers require further studies before translation into clinical use. The application of therapeutic radionuclides offers a very promising clinical application of these tracers in managing drug-resistant fungi. |
| first_indexed | 2024-03-10T11:09:23Z |
| format | Article |
| id | doaj.art-7e143c01f4d44203bb967556026467d5 |
| institution | Directory Open Access Journal |
| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-10T11:09:23Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-7e143c01f4d44203bb967556026467d52023-11-21T20:56:30ZengMDPI AGJournal of Fungi2309-608X2021-05-017640710.3390/jof7060407Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense ResponseAlfred O. Ankrah0Mike M. Sathekge1Rudi A. J. O. Dierckx2Andor W. J. M. Glaudemans3National Centre for Radiotherapy Oncology and Nuclear Medicine, Korle Bu Teaching Hospital, Accra GA-222 7974, GhanaDepartment of Nuclear Medicine, University of Pretoria, Steve Biko Academic Hospital, Pretoria 0001, South AfricaMedical Imaging Center, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsMedical Imaging Center, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The NetherlandsThe human response to invading fungi includes a series of events that detect, kill, or clear the fungi. If the metabolic host response is unable to eliminate the fungi, an infection ensues. Some of the host response’s metabolic events to fungi can be imaged with molecules labelled with radionuclides. Several important clinical applications have been found with radiolabelled biomolecules of inflammation. <sup>18</sup>F-fluorodeoxyglucose is the tracer that has been most widely investigated in the host defence of fungi. This tracer has added value in the early detection of infection, in staging and visualising dissemination of infection, and in monitoring antifungal treatment. Radiolabelled antimicrobial peptides showed promising results, but large prospective studies in fungal infection are lacking. Other tracers have also been used in imaging events of the host response, such as the migration of white blood cells at sites of infection, nutritional immunity in iron metabolism, and radiolabelled monoclonal antibodies. Many tracers are still at the preclinical stage. Some tracers require further studies before translation into clinical use. The application of therapeutic radionuclides offers a very promising clinical application of these tracers in managing drug-resistant fungi.https://www.mdpi.com/2309-608X/7/6/407fungihost defenceinflammationinvasive fungal infectionsradionuclidesPET |
| spellingShingle | Alfred O. Ankrah Mike M. Sathekge Rudi A. J. O. Dierckx Andor W. J. M. Glaudemans Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense Response Journal of Fungi fungi host defence inflammation invasive fungal infections radionuclides PET |
| title | Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense Response |
| title_full | Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense Response |
| title_fullStr | Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense Response |
| title_full_unstemmed | Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense Response |
| title_short | Radionuclide Imaging of Fungal Infections and Correlation with the Host Defense Response |
| title_sort | radionuclide imaging of fungal infections and correlation with the host defense response |
| topic | fungi host defence inflammation invasive fungal infections radionuclides PET |
| url | https://www.mdpi.com/2309-608X/7/6/407 |
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