Adipocytokines in Diabetes Mellitus: A Study from a Rural Setting in Haryana, India
Introduction: Diabetes Mellitus (DM) and Obesity are the biggest public health challenges of 21st century. Both these disorders are associated with several co-morbidities like hypertension, hyperlipidemia, Cardiovascular Diseases (CVD) etc., that may be linked to the underlying insulin resistanc...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Pvt. Ltd.
2021-01-01
|
| Series: | National Journal of Laboratory Medicine |
| Subjects: | |
| Online Access: | http://www.njlm.net/articles/PDF/2467/46249_CE[Ra1]_F(SHU)_PF1(AG_OM)_PFA(SHU)_PB(AG_SHU)_GC(SHU)_PN(SHU).pdf |
| _version_ | 1818619805191634944 |
|---|---|
| author | Priyanka Tangri Nitin Tangri |
| author_facet | Priyanka Tangri Nitin Tangri |
| author_sort | Priyanka Tangri |
| collection | DOAJ |
| description | Introduction: Diabetes Mellitus (DM) and Obesity are the biggest
public health challenges of 21st century. Both these disorders
are associated with several co-morbidities like hypertension,
hyperlipidemia, Cardiovascular Diseases (CVD) etc., that may
be linked to the underlying insulin resistance, hyperglycaemia,
dyslipidemia, hyperinsulinemia and altered levels of adipocytederived hormones. Furthermore, clinical studies in humans have
suggested the possible correlation of plasma concentration
of several adipocytokines and measures of adiposity, insulin
resistance and endothelial function in humans.
Aim: To estimate and compare the serum levels of leptin and
adiponectin in patients with Type 2 Diabetes Mellitus (T2DM)
and in non-diabetic subjects with and without obesity.
Materials and Methods: In the study, 200 T2DM patients (with
and without obesity) and 200 non-diabetic subjects (with and
without obesity) aged between 30-70 years of either sex were
included. In all the subjects included in the study, serum leptin
and adiponectin levels were estimated using Enzyme Linked
Immunosorbent Assay (ELISA) method.
Results: It was observed that the serum adiponectin levels
decreased while leptin levels increased significantly (p<0.001) in
obese than non-obese diabetics. Similarly, obese non-diabetics
showed higher serum leptin and lower adiponectin levels than
their non-obese counterparts (p<0.001).
Conclusion: Serum levels of leptin and adiponectin are altered in
subjects with T2DM and obesity which may indicate the potential
role of adipocytokines as an important link between increased
fat mass, insulin resistance, deranged glucose metabolism and
endothelial dysfunction especially in diabetic patients. |
| first_indexed | 2024-12-16T17:43:19Z |
| format | Article |
| id | doaj.art-7e15f359e71b4684b2f12885046065da |
| institution | Directory Open Access Journal |
| issn | 2277-8551 2455-6882 |
| language | English |
| last_indexed | 2024-12-16T17:43:19Z |
| publishDate | 2021-01-01 |
| publisher | JCDR Research and Publications Pvt. Ltd. |
| record_format | Article |
| series | National Journal of Laboratory Medicine |
| spelling | doaj.art-7e15f359e71b4684b2f12885046065da2022-12-21T22:22:32ZengJCDR Research and Publications Pvt. Ltd.National Journal of Laboratory Medicine2277-85512455-68822021-01-01102BO05BO0810.7860/NJLM/2021/46249:2467Adipocytokines in Diabetes Mellitus: A Study from a Rural Setting in Haryana, IndiaPriyanka Tangri0Nitin Tangri1Associate Professor, Department of Biochemistry, Dr. Radhakrishnan Government Medical College, Hamirpur, Himachal Pradesh, India.Associate Professor, Department of Pulmonary Medicine, Dr. Radhakrishnan Government Medical College, Hamirpur, Himachal Pradesh, India.Introduction: Diabetes Mellitus (DM) and Obesity are the biggest public health challenges of 21st century. Both these disorders are associated with several co-morbidities like hypertension, hyperlipidemia, Cardiovascular Diseases (CVD) etc., that may be linked to the underlying insulin resistance, hyperglycaemia, dyslipidemia, hyperinsulinemia and altered levels of adipocytederived hormones. Furthermore, clinical studies in humans have suggested the possible correlation of plasma concentration of several adipocytokines and measures of adiposity, insulin resistance and endothelial function in humans. Aim: To estimate and compare the serum levels of leptin and adiponectin in patients with Type 2 Diabetes Mellitus (T2DM) and in non-diabetic subjects with and without obesity. Materials and Methods: In the study, 200 T2DM patients (with and without obesity) and 200 non-diabetic subjects (with and without obesity) aged between 30-70 years of either sex were included. In all the subjects included in the study, serum leptin and adiponectin levels were estimated using Enzyme Linked Immunosorbent Assay (ELISA) method. Results: It was observed that the serum adiponectin levels decreased while leptin levels increased significantly (p<0.001) in obese than non-obese diabetics. Similarly, obese non-diabetics showed higher serum leptin and lower adiponectin levels than their non-obese counterparts (p<0.001). Conclusion: Serum levels of leptin and adiponectin are altered in subjects with T2DM and obesity which may indicate the potential role of adipocytokines as an important link between increased fat mass, insulin resistance, deranged glucose metabolism and endothelial dysfunction especially in diabetic patients.http://www.njlm.net/articles/PDF/2467/46249_CE[Ra1]_F(SHU)_PF1(AG_OM)_PFA(SHU)_PB(AG_SHU)_GC(SHU)_PN(SHU).pdfcardiovascular diseaseinsulin resistanceobesity |
| spellingShingle | Priyanka Tangri Nitin Tangri Adipocytokines in Diabetes Mellitus: A Study from a Rural Setting in Haryana, India National Journal of Laboratory Medicine cardiovascular disease insulin resistance obesity |
| title | Adipocytokines in Diabetes Mellitus: A Study from a Rural Setting in Haryana, India |
| title_full | Adipocytokines in Diabetes Mellitus: A Study from a Rural Setting in Haryana, India |
| title_fullStr | Adipocytokines in Diabetes Mellitus: A Study from a Rural Setting in Haryana, India |
| title_full_unstemmed | Adipocytokines in Diabetes Mellitus: A Study from a Rural Setting in Haryana, India |
| title_short | Adipocytokines in Diabetes Mellitus: A Study from a Rural Setting in Haryana, India |
| title_sort | adipocytokines in diabetes mellitus a study from a rural setting in haryana india |
| topic | cardiovascular disease insulin resistance obesity |
| url | http://www.njlm.net/articles/PDF/2467/46249_CE[Ra1]_F(SHU)_PF1(AG_OM)_PFA(SHU)_PB(AG_SHU)_GC(SHU)_PN(SHU).pdf |
| work_keys_str_mv | AT priyankatangri adipocytokinesindiabetesmellitusastudyfromaruralsettinginharyanaindia AT nitintangri adipocytokinesindiabetesmellitusastudyfromaruralsettinginharyanaindia |