A Novel Model Combining Tumor Length, Tumor Thickness, TNM_Stage, Nutritional Index, and Inflammatory Index Might Be Superior to the 8th TNM Staging Criteria in Predicting the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated With Definitive Chemoradiotherapy
BackgroundWe aimed to determine whether the tumor length and tumor thickness should be used as prognostic factors for esophageal squamous cell carcinoma (ESCC) patients treated with definitive chemoradiotherapy (dCRT).MethodsA retrospective analysis consists of 902 non-operative ESCC patients receiv...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.896788/full |
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| author | Xiaohui Chen Xiaohui Chen Xiaohui Chen Yilin Yu Yilin Yu Haishan Wu Haishan Wu Jianjian Qiu Jianjian Qiu Dongmei Ke Dongmei Ke Yahua Wu Yahua Wu Mingqiang Lin Mingqiang Lin Tianxiu Liu Tianxiu Liu Qunhao Zheng Qunhao Zheng Hongying Zheng Hongying Zheng Jun Yang Jun Yang Zhiping Wang Zhiping Wang Hui Li Lingyun Liu Lingyun Liu Qiwei Yao Qiwei Yao Qiwei Yao Jiancheng Li Jiancheng Li Jiancheng Li Wenfang Cheng Wenfang Cheng Wenfang Cheng |
| author_facet | Xiaohui Chen Xiaohui Chen Xiaohui Chen Yilin Yu Yilin Yu Haishan Wu Haishan Wu Jianjian Qiu Jianjian Qiu Dongmei Ke Dongmei Ke Yahua Wu Yahua Wu Mingqiang Lin Mingqiang Lin Tianxiu Liu Tianxiu Liu Qunhao Zheng Qunhao Zheng Hongying Zheng Hongying Zheng Jun Yang Jun Yang Zhiping Wang Zhiping Wang Hui Li Lingyun Liu Lingyun Liu Qiwei Yao Qiwei Yao Qiwei Yao Jiancheng Li Jiancheng Li Jiancheng Li Wenfang Cheng Wenfang Cheng Wenfang Cheng |
| author_sort | Xiaohui Chen |
| collection | DOAJ |
| description | BackgroundWe aimed to determine whether the tumor length and tumor thickness should be used as prognostic factors for esophageal squamous cell carcinoma (ESCC) patients treated with definitive chemoradiotherapy (dCRT).MethodsA retrospective analysis consists of 902 non-operative ESCC patients received dCRT. The nomogram was used to predict the survival. Besides, Restricted Cubic Splines (RCS) was used to examine the relationship between prognostic factors and survival outcomes. Finally, the prognostic index (PI) scores were constructed according to the tumor length and tumor thickness, and the patients were divided into the low-, medium-, and high-risk groups.ResultsThe median follow-up of overall survival (OS) and progression-free survival (PFS) were 23.0 months and 17.5 months. Multivariate Cox regression analysis showed that tumor length and tumor thickness were independent prognostic factors associated with survival. Our novel nomograms for OS and PFS were superior to the TNM classification (p < 0.001). Besides, RCS analysis demonstrated that the death hazard of tumor length and tumor thickness sharply increased at 7.7 cm and 1.6 cm (p < 0.001). Finally, there were significant differences for ESCC patients with clinical TNM stage group of the OS and PFS in different risk groups. The higher risk group was significantly associated with shorter OS and PFS in ESCC patients (both p < 0.001 for all).ConclusionThe study results suggest that the novel models integrating tumor length and tumor thickness may provide a simple and widely available method for evaluating the prognosis of non-operative ESCC patients. The tumor length and tumor thickness should be considered as prognostic factors for ESCC. |
| first_indexed | 2024-04-13T22:22:52Z |
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| id | doaj.art-7e160fab1db54219be58e1f0a82175c1 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T22:22:52Z |
| publishDate | 2022-06-01 |
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| series | Frontiers in Oncology |
| spelling | doaj.art-7e160fab1db54219be58e1f0a82175c12022-12-22T02:27:10ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.896788896788A Novel Model Combining Tumor Length, Tumor Thickness, TNM_Stage, Nutritional Index, and Inflammatory Index Might Be Superior to the 8th TNM Staging Criteria in Predicting the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated With Definitive ChemoradiotherapyXiaohui Chen0Xiaohui Chen1Xiaohui Chen2Yilin Yu3Yilin Yu4Haishan Wu5Haishan Wu6Jianjian Qiu7Jianjian Qiu8Dongmei Ke9Dongmei Ke10Yahua Wu11Yahua Wu12Mingqiang Lin13Mingqiang Lin14Tianxiu Liu15Tianxiu Liu16Qunhao Zheng17Qunhao Zheng18Hongying Zheng19Hongying Zheng20Jun Yang21Jun Yang22Zhiping Wang23Zhiping Wang24Hui Li25Lingyun Liu26Lingyun Liu27Qiwei Yao28Qiwei Yao29Qiwei Yao30Jiancheng Li31Jiancheng Li32Jiancheng Li33Wenfang Cheng34Wenfang Cheng35Wenfang Cheng36Department of Thoracic Surgery, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaGraduate School of Fujian Medical University , Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaGraduate School of Fujian Medical University , Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaGraduate School of Fujian Medical University , Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaCollege of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, ChinaGraduate School of Fujian Medical University , Fuzhou, ChinaDepartment of Radiation Oncology, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, ChinaBackgroundWe aimed to determine whether the tumor length and tumor thickness should be used as prognostic factors for esophageal squamous cell carcinoma (ESCC) patients treated with definitive chemoradiotherapy (dCRT).MethodsA retrospective analysis consists of 902 non-operative ESCC patients received dCRT. The nomogram was used to predict the survival. Besides, Restricted Cubic Splines (RCS) was used to examine the relationship between prognostic factors and survival outcomes. Finally, the prognostic index (PI) scores were constructed according to the tumor length and tumor thickness, and the patients were divided into the low-, medium-, and high-risk groups.ResultsThe median follow-up of overall survival (OS) and progression-free survival (PFS) were 23.0 months and 17.5 months. Multivariate Cox regression analysis showed that tumor length and tumor thickness were independent prognostic factors associated with survival. Our novel nomograms for OS and PFS were superior to the TNM classification (p < 0.001). Besides, RCS analysis demonstrated that the death hazard of tumor length and tumor thickness sharply increased at 7.7 cm and 1.6 cm (p < 0.001). Finally, there were significant differences for ESCC patients with clinical TNM stage group of the OS and PFS in different risk groups. The higher risk group was significantly associated with shorter OS and PFS in ESCC patients (both p < 0.001 for all).ConclusionThe study results suggest that the novel models integrating tumor length and tumor thickness may provide a simple and widely available method for evaluating the prognosis of non-operative ESCC patients. The tumor length and tumor thickness should be considered as prognostic factors for ESCC.https://www.frontiersin.org/articles/10.3389/fonc.2022.896788/fullnovel prognostic modeltumor lengthtumor thicknessesophageal squamous cell carcinomaprognostic index score |
| spellingShingle | Xiaohui Chen Xiaohui Chen Xiaohui Chen Yilin Yu Yilin Yu Haishan Wu Haishan Wu Jianjian Qiu Jianjian Qiu Dongmei Ke Dongmei Ke Yahua Wu Yahua Wu Mingqiang Lin Mingqiang Lin Tianxiu Liu Tianxiu Liu Qunhao Zheng Qunhao Zheng Hongying Zheng Hongying Zheng Jun Yang Jun Yang Zhiping Wang Zhiping Wang Hui Li Lingyun Liu Lingyun Liu Qiwei Yao Qiwei Yao Qiwei Yao Jiancheng Li Jiancheng Li Jiancheng Li Wenfang Cheng Wenfang Cheng Wenfang Cheng A Novel Model Combining Tumor Length, Tumor Thickness, TNM_Stage, Nutritional Index, and Inflammatory Index Might Be Superior to the 8th TNM Staging Criteria in Predicting the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated With Definitive Chemoradiotherapy Frontiers in Oncology novel prognostic model tumor length tumor thickness esophageal squamous cell carcinoma prognostic index score |
| title | A Novel Model Combining Tumor Length, Tumor Thickness, TNM_Stage, Nutritional Index, and Inflammatory Index Might Be Superior to the 8th TNM Staging Criteria in Predicting the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated With Definitive Chemoradiotherapy |
| title_full | A Novel Model Combining Tumor Length, Tumor Thickness, TNM_Stage, Nutritional Index, and Inflammatory Index Might Be Superior to the 8th TNM Staging Criteria in Predicting the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated With Definitive Chemoradiotherapy |
| title_fullStr | A Novel Model Combining Tumor Length, Tumor Thickness, TNM_Stage, Nutritional Index, and Inflammatory Index Might Be Superior to the 8th TNM Staging Criteria in Predicting the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated With Definitive Chemoradiotherapy |
| title_full_unstemmed | A Novel Model Combining Tumor Length, Tumor Thickness, TNM_Stage, Nutritional Index, and Inflammatory Index Might Be Superior to the 8th TNM Staging Criteria in Predicting the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated With Definitive Chemoradiotherapy |
| title_short | A Novel Model Combining Tumor Length, Tumor Thickness, TNM_Stage, Nutritional Index, and Inflammatory Index Might Be Superior to the 8th TNM Staging Criteria in Predicting the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated With Definitive Chemoradiotherapy |
| title_sort | novel model combining tumor length tumor thickness tnm stage nutritional index and inflammatory index might be superior to the 8th tnm staging criteria in predicting the prognosis of esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy |
| topic | novel prognostic model tumor length tumor thickness esophageal squamous cell carcinoma prognostic index score |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.896788/full |
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novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT hongyingzheng novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT hongyingzheng novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT junyang novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT junyang novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT zhipingwang novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT zhipingwang novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT huili novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT lingyunliu novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT lingyunliu novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT qiweiyao novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT qiweiyao novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT qiweiyao novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT jianchengli novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT jianchengli novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT jianchengli novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT wenfangcheng novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT wenfangcheng novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy AT wenfangcheng novelmodelcombiningtumorlengthtumorthicknesstnmstagenutritionalindexandinflammatoryindexmightbesuperiortothe8thtnmstagingcriteriainpredictingtheprognosisofesophagealsquamouscellcarcinomapatientstreatedwithdefinitivechemoradiotherapy |