HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma
Glaucoma is a result of increased intraocular pressure leading to damage to retinal ganglion cells and<br />optic nerve axons. The aim of this study was to evaluate HIF-1 expression in optic nerve axons and retinal<br />ganglion cells in 42 eyes enucleated because of comp...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Via Medica
2012-10-01
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| Series: | Folia Histochemica et Cytobiologica |
| Online Access: | http://czasopisma.viamedica.pl/fhc/article/view/19757 |
| _version_ | 1811339188842266624 |
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| author | Joanna Reszeć Renata Zalewska Piotr Bernaczyk Lech Chyczewski |
| author_facet | Joanna Reszeć Renata Zalewska Piotr Bernaczyk Lech Chyczewski |
| author_sort | Joanna Reszeć |
| collection | DOAJ |
| description | Glaucoma is a result of increased intraocular pressure leading to damage to retinal ganglion cells and<br />optic nerve axons. The aim of this study was to evaluate HIF-1 expression in optic nerve axons and retinal<br />ganglion cells in 42 eyes enucleated because of complete glaucoma compared to eyes removed because of injury.<br />The immunohistochemical reaction was done and specimens were examined under a light microscope. 57% of<br />cases presented HIF-1 expression in the optic nerve axons, and 52.3% in the retinal ganglion cells. 20 out of 42<br />(47.6%) cases were HIF-1 positive both in the optic nerve axons and in the retinal ganglion cells, and the staining<br />was evident mostly in the nuclear and perinuclear area. Our present results indicate that HIF-1 expression in<br />hypoxic conditions in glaucoma might be a very crucial stage in damage to retinal ganglion cells and optic nerve<br />axons, and might be a successful target for the implementation of neuroprotective drugs.<br>Glaucoma is a result of increased intraocular pressure leading to damage to retinal ganglion cells and<br />optic nerve axons. The aim of this study was to evaluate HIF-1 expression in optic nerve axons and retinal<br />ganglion cells in 42 eyes enucleated because of complete glaucoma compared to eyes removed because of injury.<br />The immunohistochemical reaction was done and specimens were examined under a light microscope. 57% of<br />cases presented HIF-1 expression in the optic nerve axons, and 52.3% in the retinal ganglion cells. 20 out of 42<br />(47.6%) cases were HIF-1 positive both in the optic nerve axons and in the retinal ganglion cells, and the staining<br />was evident mostly in the nuclear and perinuclear area. Our present results indicate that HIF-1 expression in<br />hypoxic conditions in glaucoma might be a very crucial stage in damage to retinal ganglion cells and optic nerve<br />axons, and might be a successful target for the implementation of neuroprotective drugs. |
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| format | Article |
| id | doaj.art-7e161402aca04e81a45faa1d92de1de6 |
| institution | Directory Open Access Journal |
| issn | 0239-8508 1897-5631 |
| language | English |
| last_indexed | 2024-04-13T18:21:39Z |
| publishDate | 2012-10-01 |
| publisher | Via Medica |
| record_format | Article |
| series | Folia Histochemica et Cytobiologica |
| spelling | doaj.art-7e161402aca04e81a45faa1d92de1de62022-12-22T02:35:24ZengVia MedicaFolia Histochemica et Cytobiologica0239-85081897-56312012-10-0150345645910.5603/19757HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucomaJoanna ReszećRenata ZalewskaPiotr BernaczykLech ChyczewskiGlaucoma is a result of increased intraocular pressure leading to damage to retinal ganglion cells and<br />optic nerve axons. The aim of this study was to evaluate HIF-1 expression in optic nerve axons and retinal<br />ganglion cells in 42 eyes enucleated because of complete glaucoma compared to eyes removed because of injury.<br />The immunohistochemical reaction was done and specimens were examined under a light microscope. 57% of<br />cases presented HIF-1 expression in the optic nerve axons, and 52.3% in the retinal ganglion cells. 20 out of 42<br />(47.6%) cases were HIF-1 positive both in the optic nerve axons and in the retinal ganglion cells, and the staining<br />was evident mostly in the nuclear and perinuclear area. Our present results indicate that HIF-1 expression in<br />hypoxic conditions in glaucoma might be a very crucial stage in damage to retinal ganglion cells and optic nerve<br />axons, and might be a successful target for the implementation of neuroprotective drugs.<br>Glaucoma is a result of increased intraocular pressure leading to damage to retinal ganglion cells and<br />optic nerve axons. The aim of this study was to evaluate HIF-1 expression in optic nerve axons and retinal<br />ganglion cells in 42 eyes enucleated because of complete glaucoma compared to eyes removed because of injury.<br />The immunohistochemical reaction was done and specimens were examined under a light microscope. 57% of<br />cases presented HIF-1 expression in the optic nerve axons, and 52.3% in the retinal ganglion cells. 20 out of 42<br />(47.6%) cases were HIF-1 positive both in the optic nerve axons and in the retinal ganglion cells, and the staining<br />was evident mostly in the nuclear and perinuclear area. Our present results indicate that HIF-1 expression in<br />hypoxic conditions in glaucoma might be a very crucial stage in damage to retinal ganglion cells and optic nerve<br />axons, and might be a successful target for the implementation of neuroprotective drugs.http://czasopisma.viamedica.pl/fhc/article/view/19757 |
| spellingShingle | Joanna Reszeć Renata Zalewska Piotr Bernaczyk Lech Chyczewski HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma Folia Histochemica et Cytobiologica |
| title | HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma |
| title_full | HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma |
| title_fullStr | HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma |
| title_full_unstemmed | HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma |
| title_short | HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma HIF-1 expression in retinal ganglion cells and optic nerve axons in glaucoma |
| title_sort | hif 1 expression in retinal ganglion cells and optic nerve axons in glaucoma hif 1 expression in retinal ganglion cells and optic nerve axons in glaucoma |
| url | http://czasopisma.viamedica.pl/fhc/article/view/19757 |
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