Incidence of neurocutaneous melanosis in Japanese pediatric patients with congenital melanocytic nevi
Abstract Neurocutaneous melanosis (NCM) is a rare, non-hereditary neurocutaneous disorder characterized by excessive melanocytic proliferation in the skin and central nervous system. As no major studies have covered the incidence of NCM among Japanese patients with congenital melanocytic nevi (CMN),...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| 格式: | 文件 |
| 语言: | English |
| 出版: |
Nature Portfolio
2023-09-01
|
| 丛编: | Scientific Reports |
| 在线阅读: | https://doi.org/10.1038/s41598-023-43829-w |
| _version_ | 1827634889353068544 |
|---|---|
| author | Miyuki Takiya Yasutaka Fushimi Michiharu Sakamoto Takeshi Yoshida Kentaro Ueno Satoshi Nakajima Akihiko Sakata Sachi Okuchi Sayo Otani Hiroshi Tagawa Naoki Morimoto Yuji Nakamoto |
| author_facet | Miyuki Takiya Yasutaka Fushimi Michiharu Sakamoto Takeshi Yoshida Kentaro Ueno Satoshi Nakajima Akihiko Sakata Sachi Okuchi Sayo Otani Hiroshi Tagawa Naoki Morimoto Yuji Nakamoto |
| author_sort | Miyuki Takiya |
| collection | DOAJ |
| description | Abstract Neurocutaneous melanosis (NCM) is a rare, non-hereditary neurocutaneous disorder characterized by excessive melanocytic proliferation in the skin and central nervous system. As no major studies have covered the incidence of NCM among Japanese patients with congenital melanocytic nevi (CMN), we prospectively investigated the incidence of NCM among Japanese patients who underwent initial treatment for CMN. The relationship of CMN and NCM was also investigated. Japanese pediatric patients with CMN under 1 year of age were included between January 2020 and November 2022, and all patients underwent brain MRI to check for NCM in this study. NCM lesions were most frequently seen in the amygdala, followed by the cerebellum, brainstem, and cerebral hemispheres. NCM was diagnosed on brain MRI in 31.6% of the 38 patients with CMN and in 25.0% of patients with no prior examination or treatment. Distribution and size of CMN, number of satellite nevi, rugosity and nodules were strongly associated with the existence of NCM, and these findings may guide a future registry study with a large cohort of CMN patients. |
| first_indexed | 2024-03-09T15:19:36Z |
| format | Article |
| id | doaj.art-7e16be76d4774e948e5b90c663d8dab5 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:19:36Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-7e16be76d4774e948e5b90c663d8dab52023-11-26T12:51:57ZengNature PortfolioScientific Reports2045-23222023-09-011311810.1038/s41598-023-43829-wIncidence of neurocutaneous melanosis in Japanese pediatric patients with congenital melanocytic neviMiyuki Takiya0Yasutaka Fushimi1Michiharu Sakamoto2Takeshi Yoshida3Kentaro Ueno4Satoshi Nakajima5Akihiko Sakata6Sachi Okuchi7Sayo Otani8Hiroshi Tagawa9Naoki Morimoto10Yuji Nakamoto11Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto UniversityDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto UniversityDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto UniversityDepartment of Pediatrics, Graduate School of Medicine, Kyoto UniversityDepartment of Biomedical Statistics and Bioinformatics, Graduate School of Medicine, Kyoto UniversityDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto UniversityDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto UniversityDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto UniversityDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto UniversityDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto UniversityDepartment of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto UniversityDepartment of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto UniversityAbstract Neurocutaneous melanosis (NCM) is a rare, non-hereditary neurocutaneous disorder characterized by excessive melanocytic proliferation in the skin and central nervous system. As no major studies have covered the incidence of NCM among Japanese patients with congenital melanocytic nevi (CMN), we prospectively investigated the incidence of NCM among Japanese patients who underwent initial treatment for CMN. The relationship of CMN and NCM was also investigated. Japanese pediatric patients with CMN under 1 year of age were included between January 2020 and November 2022, and all patients underwent brain MRI to check for NCM in this study. NCM lesions were most frequently seen in the amygdala, followed by the cerebellum, brainstem, and cerebral hemispheres. NCM was diagnosed on brain MRI in 31.6% of the 38 patients with CMN and in 25.0% of patients with no prior examination or treatment. Distribution and size of CMN, number of satellite nevi, rugosity and nodules were strongly associated with the existence of NCM, and these findings may guide a future registry study with a large cohort of CMN patients.https://doi.org/10.1038/s41598-023-43829-w |
| spellingShingle | Miyuki Takiya Yasutaka Fushimi Michiharu Sakamoto Takeshi Yoshida Kentaro Ueno Satoshi Nakajima Akihiko Sakata Sachi Okuchi Sayo Otani Hiroshi Tagawa Naoki Morimoto Yuji Nakamoto Incidence of neurocutaneous melanosis in Japanese pediatric patients with congenital melanocytic nevi Scientific Reports |
| title | Incidence of neurocutaneous melanosis in Japanese pediatric patients with congenital melanocytic nevi |
| title_full | Incidence of neurocutaneous melanosis in Japanese pediatric patients with congenital melanocytic nevi |
| title_fullStr | Incidence of neurocutaneous melanosis in Japanese pediatric patients with congenital melanocytic nevi |
| title_full_unstemmed | Incidence of neurocutaneous melanosis in Japanese pediatric patients with congenital melanocytic nevi |
| title_short | Incidence of neurocutaneous melanosis in Japanese pediatric patients with congenital melanocytic nevi |
| title_sort | incidence of neurocutaneous melanosis in japanese pediatric patients with congenital melanocytic nevi |
| url | https://doi.org/10.1038/s41598-023-43829-w |
| work_keys_str_mv | AT miyukitakiya incidenceofneurocutaneousmelanosisinjapanesepediatricpatientswithcongenitalmelanocyticnevi AT yasutakafushimi incidenceofneurocutaneousmelanosisinjapanesepediatricpatientswithcongenitalmelanocyticnevi AT michiharusakamoto incidenceofneurocutaneousmelanosisinjapanesepediatricpatientswithcongenitalmelanocyticnevi AT takeshiyoshida incidenceofneurocutaneousmelanosisinjapanesepediatricpatientswithcongenitalmelanocyticnevi AT kentaroueno incidenceofneurocutaneousmelanosisinjapanesepediatricpatientswithcongenitalmelanocyticnevi AT satoshinakajima incidenceofneurocutaneousmelanosisinjapanesepediatricpatientswithcongenitalmelanocyticnevi AT akihikosakata incidenceofneurocutaneousmelanosisinjapanesepediatricpatientswithcongenitalmelanocyticnevi AT sachiokuchi incidenceofneurocutaneousmelanosisinjapanesepediatricpatientswithcongenitalmelanocyticnevi AT sayootani incidenceofneurocutaneousmelanosisinjapanesepediatricpatientswithcongenitalmelanocyticnevi AT hiroshitagawa incidenceofneurocutaneousmelanosisinjapanesepediatricpatientswithcongenitalmelanocyticnevi AT naokimorimoto incidenceofneurocutaneousmelanosisinjapanesepediatricpatientswithcongenitalmelanocyticnevi AT yujinakamoto incidenceofneurocutaneousmelanosisinjapanesepediatricpatientswithcongenitalmelanocyticnevi |