Serum Level of ADAMTS4 and ADAMTS8 in Patients with Psoriatic Arthritis
Objective: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a large family of proteoglycanase enzymes that show proteolytic activity. The expression levels of ADAMTS proteases in osteoart...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2020-12-01
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| Series: | Erciyes Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=erciyesmedj&un=EMJ-65625 |
| _version_ | 1797908755924385792 |
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| author | Irmak Icen Taskin Sevgi Irtegun Kandemir Kemal Nas Abdullah Zübeyir Dağlı |
| author_facet | Irmak Icen Taskin Sevgi Irtegun Kandemir Kemal Nas Abdullah Zübeyir Dağlı |
| author_sort | Irmak Icen Taskin |
| collection | DOAJ |
| description | Objective: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a large family of proteoglycanase enzymes that show proteolytic activity. The expression levels of ADAMTS proteases in osteoarthritis and rheumatoid arthritis are upregulated. However, their expression levels in PsA patients have not been examined yet. The aim of this study was to determine the serum levels of ADAMTS4 and ADAMTS8 in PsA patients.
Materials and Methods: This was a case-control study and enrolled 40 PsA patients and 40 individuals as controls. Serum levels of ADAMTS4 and ADAMTS8 were examined by the enzyme-linked immunosorbent assay (ELISA). The relationship between ADAMTS8 levels and demographic and clinical features of PsA patients were analyzed.
Results: The results of this study showed that the ADAMTS8 level was significantly elevated in the serum of PsA patients (160.9+-49.79 pg/mL) compared to the control groups (<15.6 pg/mL). An association (r=0.32, p<0.05) was detected between age and serum level of ADAMTS8. However, the level of the ADAMTS4 in many subjects was under the detectable range.
Conclusion: Our results conclude that a relationship exists between ADAMTS8 and PsA, but further investigations are required to establish the function of ADAMTS8 proteases in PsA. |
| first_indexed | 2024-04-10T10:57:34Z |
| format | Article |
| id | doaj.art-7e16ff6bd97c49fc9605b1f7e78c1792 |
| institution | Directory Open Access Journal |
| issn | 2149-2247 |
| language | English |
| last_indexed | 2024-04-10T10:57:34Z |
| publishDate | 2020-12-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Erciyes Medical Journal |
| spelling | doaj.art-7e16ff6bd97c49fc9605b1f7e78c17922023-02-15T16:19:50ZengKARE PublishingErciyes Medical Journal2149-22472020-12-01431202510.14744/etd.2020.65625EMJ-65625Serum Level of ADAMTS4 and ADAMTS8 in Patients with Psoriatic ArthritisIrmak Icen Taskin0Sevgi Irtegun Kandemir1Kemal Nas2Abdullah Zübeyir Dağlı3Department of Molecular Biology and Genetic, İnönü University Faculty of Science and Art, Malatya, TurkeyDepartment of Medical Biology, Dicle University Faculty of Medicine, Diyarbakır, TurkeyDivision of Rheumatology and Immunology, Department of Physical Medicine and Rehabilitation, Sakarya University Faculty of Medicine, Sakarya, TurkeyDepartment of Physical Medicine and Rehabilitation, Bitlis State Hospital, Bitlis, TurkeyObjective: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) is a large family of proteoglycanase enzymes that show proteolytic activity. The expression levels of ADAMTS proteases in osteoarthritis and rheumatoid arthritis are upregulated. However, their expression levels in PsA patients have not been examined yet. The aim of this study was to determine the serum levels of ADAMTS4 and ADAMTS8 in PsA patients. Materials and Methods: This was a case-control study and enrolled 40 PsA patients and 40 individuals as controls. Serum levels of ADAMTS4 and ADAMTS8 were examined by the enzyme-linked immunosorbent assay (ELISA). The relationship between ADAMTS8 levels and demographic and clinical features of PsA patients were analyzed. Results: The results of this study showed that the ADAMTS8 level was significantly elevated in the serum of PsA patients (160.9+-49.79 pg/mL) compared to the control groups (<15.6 pg/mL). An association (r=0.32, p<0.05) was detected between age and serum level of ADAMTS8. However, the level of the ADAMTS4 in many subjects was under the detectable range. Conclusion: Our results conclude that a relationship exists between ADAMTS8 and PsA, but further investigations are required to establish the function of ADAMTS8 proteases in PsA.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=erciyesmedj&un=EMJ-65625psoriatic arthritisadamts4adamts8biomarkers |
| spellingShingle | Irmak Icen Taskin Sevgi Irtegun Kandemir Kemal Nas Abdullah Zübeyir Dağlı Serum Level of ADAMTS4 and ADAMTS8 in Patients with Psoriatic Arthritis Erciyes Medical Journal psoriatic arthritis adamts4 adamts8 biomarkers |
| title | Serum Level of ADAMTS4 and ADAMTS8 in Patients with Psoriatic Arthritis |
| title_full | Serum Level of ADAMTS4 and ADAMTS8 in Patients with Psoriatic Arthritis |
| title_fullStr | Serum Level of ADAMTS4 and ADAMTS8 in Patients with Psoriatic Arthritis |
| title_full_unstemmed | Serum Level of ADAMTS4 and ADAMTS8 in Patients with Psoriatic Arthritis |
| title_short | Serum Level of ADAMTS4 and ADAMTS8 in Patients with Psoriatic Arthritis |
| title_sort | serum level of adamts4 and adamts8 in patients with psoriatic arthritis |
| topic | psoriatic arthritis adamts4 adamts8 biomarkers |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=erciyesmedj&un=EMJ-65625 |
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