Targeting ferroptosis in melanoma: cancer therapeutics
Abstract Melanoma is an aggressive kind of skin cancer; its rate has risen rapidly over the past few decades. Melanoma reports for only about 1% of skin cancers but leads to a high majority of skin cancer deaths. Thus, new useful therapeutic approaches are currently required, to state effective trea...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01296-w |
| _version_ | 1797452043532632064 |
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| author | Khatereh Khorsandi HomaSadat Esfahani Saeedeh Keyvani- Ghamsari Parisa lakhshehei |
| author_facet | Khatereh Khorsandi HomaSadat Esfahani Saeedeh Keyvani- Ghamsari Parisa lakhshehei |
| author_sort | Khatereh Khorsandi |
| collection | DOAJ |
| description | Abstract Melanoma is an aggressive kind of skin cancer; its rate has risen rapidly over the past few decades. Melanoma reports for only about 1% of skin cancers but leads to a high majority of skin cancer deaths. Thus, new useful therapeutic approaches are currently required, to state effective treatments to consistently enhance the overall survival rate of melanoma patients. Ferroptosis is a recently identified cell death process, which is different from autophagy, apoptosis, necrosis, and pyroptosis in terms of biochemistry, genetics, and morphology which plays an important role in cancer treatment. Ferroptosis happens mostly by accumulating iron and lipid peroxides in the cell. Recently, studies have revealed that ferroptosis has a key role in the tumor’s progression. Especially, inducing ferroptosis in cells can inhibit the tumor cells’ growth, leading to back warding tumorigenesis. Here, we outline the ferroptosis characteristics from its basic role in melanoma cancer and mention its possible applications in melanoma cancer treatment. Video Abstract |
| first_indexed | 2024-03-09T15:03:03Z |
| format | Article |
| id | doaj.art-7e1b43a81aa348ad9c229c633ae9b367 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-09T15:03:03Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-7e1b43a81aa348ad9c229c633ae9b3672023-11-26T13:50:11ZengBMCCell Communication and Signaling1478-811X2023-11-0121111610.1186/s12964-023-01296-wTargeting ferroptosis in melanoma: cancer therapeuticsKhatereh Khorsandi0HomaSadat Esfahani1Saeedeh Keyvani- Ghamsari2Parisa lakhshehei3Department of Photodynamics, Medical Laser Research Center, Yara Institute, ACECRDepartment of Photodynamics, Medical Laser Research Center, Yara Institute, ACECRDepartment of Microbiology, Karaj Branch, Islamic Azad UniversityDepartment of Biochemistry, Faculty of Biological Sciences, North Tehran Branch, Islamic Azad UniversityAbstract Melanoma is an aggressive kind of skin cancer; its rate has risen rapidly over the past few decades. Melanoma reports for only about 1% of skin cancers but leads to a high majority of skin cancer deaths. Thus, new useful therapeutic approaches are currently required, to state effective treatments to consistently enhance the overall survival rate of melanoma patients. Ferroptosis is a recently identified cell death process, which is different from autophagy, apoptosis, necrosis, and pyroptosis in terms of biochemistry, genetics, and morphology which plays an important role in cancer treatment. Ferroptosis happens mostly by accumulating iron and lipid peroxides in the cell. Recently, studies have revealed that ferroptosis has a key role in the tumor’s progression. Especially, inducing ferroptosis in cells can inhibit the tumor cells’ growth, leading to back warding tumorigenesis. Here, we outline the ferroptosis characteristics from its basic role in melanoma cancer and mention its possible applications in melanoma cancer treatment. Video Abstracthttps://doi.org/10.1186/s12964-023-01296-wFerroptosisMelanomaCell deathCancer treatmentTargeted therapy |
| spellingShingle | Khatereh Khorsandi HomaSadat Esfahani Saeedeh Keyvani- Ghamsari Parisa lakhshehei Targeting ferroptosis in melanoma: cancer therapeutics Cell Communication and Signaling Ferroptosis Melanoma Cell death Cancer treatment Targeted therapy |
| title | Targeting ferroptosis in melanoma: cancer therapeutics |
| title_full | Targeting ferroptosis in melanoma: cancer therapeutics |
| title_fullStr | Targeting ferroptosis in melanoma: cancer therapeutics |
| title_full_unstemmed | Targeting ferroptosis in melanoma: cancer therapeutics |
| title_short | Targeting ferroptosis in melanoma: cancer therapeutics |
| title_sort | targeting ferroptosis in melanoma cancer therapeutics |
| topic | Ferroptosis Melanoma Cell death Cancer treatment Targeted therapy |
| url | https://doi.org/10.1186/s12964-023-01296-w |
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