Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Study of Clinical, Imaging Features and Treatment Outcomes
PurposeTo describe the clinical, imaging, pathological features and oncologic outcomes of mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney.Patients and MethodsTwenty-two cases of MTSCC were pathologically identified between January 2004 and April 2021 at our institution. The clinica...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.865263/full |
| _version_ | 1819023870414290944 |
|---|---|
| author | Xiaofeng Xu Jing Zhong Xiumin Zhou Zhifeng Wei Qiuyuan Xia Pengfei Huang Changjie Shi Jianping Da Chaopeng Tang Wen Cheng Jingping Ge |
| author_facet | Xiaofeng Xu Jing Zhong Xiumin Zhou Zhifeng Wei Qiuyuan Xia Pengfei Huang Changjie Shi Jianping Da Chaopeng Tang Wen Cheng Jingping Ge |
| author_sort | Xiaofeng Xu |
| collection | DOAJ |
| description | PurposeTo describe the clinical, imaging, pathological features and oncologic outcomes of mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney.Patients and MethodsTwenty-two cases of MTSCC were pathologically identified between January 2004 and April 2021 at our institution. The clinical and imaging findings, pathological features, treatment methods and outcomes of the patients were reviewed.ResultsThese cases included 17 women and 5 men, with a median age at diagnosis of 52.5 years. On contrast-enhanced CT, MTSCC was less enhanced than the adjacent renal parenchyma. Tumor attenuation values were 33.3 ± 6.8HU, 44.0 ± 9.1HU, 54.4 ± 13.9HU and 67.1 ± 11.8HU in the non-contrast, corticomedullary, nephrographic and excretory phases of CT, respectively. Contrast-enhanced ultrasonography and MRI also showed hypovascular features of the masses. On MRI, the tumors were isointense on T1-weighted images and slightly hypo- or hyperintense on T2-weighted images. Diffusion-weighted imaging revealed a low apparent diffusion coefficient of the tumor. The patients were managed with laparoscopic partial nephrectomy (n=5), radical nephrectomy (n=16), or robotic-assisted laparoscopic partial nephrectomy (n=1). The median follow-up time was 59.5 months. All the patients were free of local recurrence or distant metastasis.ConclusionsMTSCC is generally indolent and has favorable outcomes. The imaging features of MTSCC are generally hypovascular, which is significantly different from clear cell renal cell carcinoma. However, it is still difficult to distinguish MTSCC from other hypovascular renal tumors preoperatively because their imaging features overlap. Further studies are essential to fully characterize the features of this rare RCC variant. |
| first_indexed | 2024-12-21T04:45:46Z |
| format | Article |
| id | doaj.art-7e1b7e59aeac4759b24aacd55ef923fb |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-21T04:45:46Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-7e1b7e59aeac4759b24aacd55ef923fb2022-12-21T19:15:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-04-011210.3389/fonc.2022.865263865263Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Study of Clinical, Imaging Features and Treatment OutcomesXiaofeng Xu0Jing Zhong1Xiumin Zhou2Zhifeng Wei3Qiuyuan Xia4Pengfei Huang5Changjie Shi6Jianping Da7Chaopeng Tang8Wen Cheng9Jingping Ge10Department of Urology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, ChinaDepartment of Radiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, ChinaDepartment of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Urology, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Pathology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, ChinaDepartment of Ultrasound Diagnosis, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, ChinaDepartment of Urology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, ChinaDepartment of Urology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, ChinaDepartment of Urology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, ChinaDepartment of Urology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, ChinaDepartment of Urology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, ChinaPurposeTo describe the clinical, imaging, pathological features and oncologic outcomes of mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney.Patients and MethodsTwenty-two cases of MTSCC were pathologically identified between January 2004 and April 2021 at our institution. The clinical and imaging findings, pathological features, treatment methods and outcomes of the patients were reviewed.ResultsThese cases included 17 women and 5 men, with a median age at diagnosis of 52.5 years. On contrast-enhanced CT, MTSCC was less enhanced than the adjacent renal parenchyma. Tumor attenuation values were 33.3 ± 6.8HU, 44.0 ± 9.1HU, 54.4 ± 13.9HU and 67.1 ± 11.8HU in the non-contrast, corticomedullary, nephrographic and excretory phases of CT, respectively. Contrast-enhanced ultrasonography and MRI also showed hypovascular features of the masses. On MRI, the tumors were isointense on T1-weighted images and slightly hypo- or hyperintense on T2-weighted images. Diffusion-weighted imaging revealed a low apparent diffusion coefficient of the tumor. The patients were managed with laparoscopic partial nephrectomy (n=5), radical nephrectomy (n=16), or robotic-assisted laparoscopic partial nephrectomy (n=1). The median follow-up time was 59.5 months. All the patients were free of local recurrence or distant metastasis.ConclusionsMTSCC is generally indolent and has favorable outcomes. The imaging features of MTSCC are generally hypovascular, which is significantly different from clear cell renal cell carcinoma. However, it is still difficult to distinguish MTSCC from other hypovascular renal tumors preoperatively because their imaging features overlap. Further studies are essential to fully characterize the features of this rare RCC variant.https://www.frontiersin.org/articles/10.3389/fonc.2022.865263/fullmucinous tubular and spindle cell carcinomarenal cell carcinomakidneyimaging featuresprognosis |
| spellingShingle | Xiaofeng Xu Jing Zhong Xiumin Zhou Zhifeng Wei Qiuyuan Xia Pengfei Huang Changjie Shi Jianping Da Chaopeng Tang Wen Cheng Jingping Ge Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Study of Clinical, Imaging Features and Treatment Outcomes Frontiers in Oncology mucinous tubular and spindle cell carcinoma renal cell carcinoma kidney imaging features prognosis |
| title | Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Study of Clinical, Imaging Features and Treatment Outcomes |
| title_full | Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Study of Clinical, Imaging Features and Treatment Outcomes |
| title_fullStr | Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Study of Clinical, Imaging Features and Treatment Outcomes |
| title_full_unstemmed | Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Study of Clinical, Imaging Features and Treatment Outcomes |
| title_short | Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: A Study of Clinical, Imaging Features and Treatment Outcomes |
| title_sort | mucinous tubular and spindle cell carcinoma of the kidney a study of clinical imaging features and treatment outcomes |
| topic | mucinous tubular and spindle cell carcinoma renal cell carcinoma kidney imaging features prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.865263/full |
| work_keys_str_mv | AT xiaofengxu mucinoustubularandspindlecellcarcinomaofthekidneyastudyofclinicalimagingfeaturesandtreatmentoutcomes AT jingzhong mucinoustubularandspindlecellcarcinomaofthekidneyastudyofclinicalimagingfeaturesandtreatmentoutcomes AT xiuminzhou mucinoustubularandspindlecellcarcinomaofthekidneyastudyofclinicalimagingfeaturesandtreatmentoutcomes AT zhifengwei mucinoustubularandspindlecellcarcinomaofthekidneyastudyofclinicalimagingfeaturesandtreatmentoutcomes AT qiuyuanxia mucinoustubularandspindlecellcarcinomaofthekidneyastudyofclinicalimagingfeaturesandtreatmentoutcomes AT pengfeihuang mucinoustubularandspindlecellcarcinomaofthekidneyastudyofclinicalimagingfeaturesandtreatmentoutcomes AT changjieshi mucinoustubularandspindlecellcarcinomaofthekidneyastudyofclinicalimagingfeaturesandtreatmentoutcomes AT jianpingda mucinoustubularandspindlecellcarcinomaofthekidneyastudyofclinicalimagingfeaturesandtreatmentoutcomes AT chaopengtang mucinoustubularandspindlecellcarcinomaofthekidneyastudyofclinicalimagingfeaturesandtreatmentoutcomes AT wencheng mucinoustubularandspindlecellcarcinomaofthekidneyastudyofclinicalimagingfeaturesandtreatmentoutcomes AT jingpingge mucinoustubularandspindlecellcarcinomaofthekidneyastudyofclinicalimagingfeaturesandtreatmentoutcomes |