In Silico and In Vitro Analyses Validate Human MicroRNAs Targeting the SARS-CoV-2 3′-UTR

In Silico and In Vitro Analyses Validate Human MicroRNAs Targeting the SARS-CoV-2 3′-UTR

COVID-19 pandemic is caused by betacoronavirus SARS-CoV-2. The genome of this virus is composed of a single strand of RNA with 5′ and 3′-UTR flanking a region of protein-coding ORFs closely resembling cells’ mRNAs. MicroRNAs are endogenous post-transcriptional regulators that target mRNA to modulate...

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Bibliographic Details
Main Authors: María Asunción Barreda-Manso, Manuel Nieto-Díaz, Altea Soto, Teresa Muñoz-Galdeano, David Reigada, Rodrigo M. Maza
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
SARS-CoV-2 3′-UTR
hsa-miR-3941
hsa-miR-138-5p
antiviral defense
Online Access:https://www.mdpi.com/1422-0067/22/11/6094

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