Polyoxygenated Terpenoids and Polyketides from the Roots of <i>Flueggea virosa</i> and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation
Six new polyoxygenated terpenoids, podovirosanes A–F (<b>1</b>–<b>6</b>), and two known polyketides (<b>7</b> and <b>8</b>) were isolated from the roots of <i>F. virosa</i>. Their structures, along with absolute configurations, were deduced...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/23/8548 |
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| author | Ju-Chien Cheng Yi-Ju Chen Chi-Wen Chuang Ya-Hsuan Chao Hui-Chi Huang Chia-Chi Lin Chih-Hua Chao |
| author_facet | Ju-Chien Cheng Yi-Ju Chen Chi-Wen Chuang Ya-Hsuan Chao Hui-Chi Huang Chia-Chi Lin Chih-Hua Chao |
| author_sort | Ju-Chien Cheng |
| collection | DOAJ |
| description | Six new polyoxygenated terpenoids, podovirosanes A–F (<b>1</b>–<b>6</b>), and two known polyketides (<b>7</b> and <b>8</b>) were isolated from the roots of <i>F. virosa</i>. Their structures, along with absolute configurations, were deduced using spectroscopic analysis as well as computational calculations, including TDDFT calculation of ECD spectra and GIAO NMR calculations combined with DP4+ probability analysis. Compounds <b>2</b>, <b>3</b>, <b>5</b>, and <b>8</b> were found to reduce the phosphorylation levels of NF-<i>κ</i>B p65 in SARS-CoV-2 pseudovirus-stimulated PMA-differentiated THP-1 cells. |
| first_indexed | 2024-03-09T17:38:46Z |
| format | Article |
| id | doaj.art-7e1ca33d041e4431a49ba29c27b171ea |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T17:38:46Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7e1ca33d041e4431a49ba29c27b171ea2023-11-24T11:44:04ZengMDPI AGMolecules1420-30492022-12-012723854810.3390/molecules27238548Polyoxygenated Terpenoids and Polyketides from the Roots of <i>Flueggea virosa</i> and Their Inhibitory Effect against SARS-CoV-2-Induced InflammationJu-Chien Cheng0Yi-Ju Chen1Chi-Wen Chuang2Ya-Hsuan Chao3Hui-Chi Huang4Chia-Chi Lin5Chih-Hua Chao6Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 40402, TaiwanCore Facility Center, Office of Research and Development, Taipei Medical University, Taipei 110301, TaiwanSchool of Pharmacy, China Medical University, Taichung 406040, TaiwanDepartment of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 40402, TaiwanDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, TaiwanDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 40402, TaiwanSchool of Pharmacy, China Medical University, Taichung 406040, TaiwanSix new polyoxygenated terpenoids, podovirosanes A–F (<b>1</b>–<b>6</b>), and two known polyketides (<b>7</b> and <b>8</b>) were isolated from the roots of <i>F. virosa</i>. Their structures, along with absolute configurations, were deduced using spectroscopic analysis as well as computational calculations, including TDDFT calculation of ECD spectra and GIAO NMR calculations combined with DP4+ probability analysis. Compounds <b>2</b>, <b>3</b>, <b>5</b>, and <b>8</b> were found to reduce the phosphorylation levels of NF-<i>κ</i>B p65 in SARS-CoV-2 pseudovirus-stimulated PMA-differentiated THP-1 cells.https://www.mdpi.com/1420-3049/27/23/8548SARS-CoV-2anti-inflammatorypodovirosanes A–F<i>Flueggea virosa</i>DP4+ |
| spellingShingle | Ju-Chien Cheng Yi-Ju Chen Chi-Wen Chuang Ya-Hsuan Chao Hui-Chi Huang Chia-Chi Lin Chih-Hua Chao Polyoxygenated Terpenoids and Polyketides from the Roots of <i>Flueggea virosa</i> and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation Molecules SARS-CoV-2 anti-inflammatory podovirosanes A–F <i>Flueggea virosa</i> DP4+ |
| title | Polyoxygenated Terpenoids and Polyketides from the Roots of <i>Flueggea virosa</i> and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation |
| title_full | Polyoxygenated Terpenoids and Polyketides from the Roots of <i>Flueggea virosa</i> and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation |
| title_fullStr | Polyoxygenated Terpenoids and Polyketides from the Roots of <i>Flueggea virosa</i> and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation |
| title_full_unstemmed | Polyoxygenated Terpenoids and Polyketides from the Roots of <i>Flueggea virosa</i> and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation |
| title_short | Polyoxygenated Terpenoids and Polyketides from the Roots of <i>Flueggea virosa</i> and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation |
| title_sort | polyoxygenated terpenoids and polyketides from the roots of i flueggea virosa i and their inhibitory effect against sars cov 2 induced inflammation |
| topic | SARS-CoV-2 anti-inflammatory podovirosanes A–F <i>Flueggea virosa</i> DP4+ |
| url | https://www.mdpi.com/1420-3049/27/23/8548 |
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