SUCCINATE DEHYDROGENASE SUBUNIT B DEFICIENT PEDIATRIC GIST
Case report Gastrointestinal stromal tumors (GISTs) occur exceedingly rare in children and adolescents. Eighty five percent of pediatric GISTs and 15 % of adult GISTs lack oncogenic mutations in KIT and PDGFRA. The results of tyrosine kinase inhibitor therapy in GIST cases with SDH deficiency are li...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-10-01
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| Series: | Hematology, Transfusion and Cell Therapy |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137922013931 |
| _version_ | 1811204864566362112 |
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| author | Melek Yaman Ortakoylu Sonay Incesoy Ozdemir Handan Dincaslan Nurdan Tacyildiz Isınsu Kuzu Emel Cabi Unal |
| author_facet | Melek Yaman Ortakoylu Sonay Incesoy Ozdemir Handan Dincaslan Nurdan Tacyildiz Isınsu Kuzu Emel Cabi Unal |
| author_sort | Melek Yaman Ortakoylu |
| collection | DOAJ |
| description | Case report Gastrointestinal stromal tumors (GISTs) occur exceedingly rare in children and adolescents. Eighty five percent of pediatric GISTs and 15 % of adult GISTs lack oncogenic mutations in KIT and PDGFRA. The results of tyrosine kinase inhibitor therapy in GIST cases with SDH deficiency are limited and controversial. Here, we would like to present a pediatric SDH deficient GIST case treated with surgery and Imatinib Mesylate. We obtained a good response with Imatinib Mesylate. |
| first_indexed | 2024-04-12T03:20:50Z |
| format | Article |
| id | doaj.art-7e1cdf8929e44ddfa7af0b8a726205cf |
| institution | Directory Open Access Journal |
| issn | 2531-1379 |
| language | English |
| last_indexed | 2024-04-12T03:20:50Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj.art-7e1cdf8929e44ddfa7af0b8a726205cf2022-12-22T03:49:55ZengElsevierHematology, Transfusion and Cell Therapy2531-13792022-10-0144S42SUCCINATE DEHYDROGENASE SUBUNIT B DEFICIENT PEDIATRIC GISTMelek Yaman Ortakoylu0Sonay Incesoy Ozdemir1Handan Dincaslan2Nurdan Tacyildiz3Isınsu Kuzu4Emel Cabi Unal5Ankara University, Department of Pediatrics, Division of Pediatric OncologyAnkara University, Department of Pediatrics, Division of Pediatric OncologyAnkara University, Department of Pediatrics, Division of Pediatric OncologyAnkara University, Department of Pediatrics, Division of Pediatric OncologyAnkara University, Department of Medical PathologyAnkara University, Department of Pediatrics, Division of Pediatric OncologyCase report Gastrointestinal stromal tumors (GISTs) occur exceedingly rare in children and adolescents. Eighty five percent of pediatric GISTs and 15 % of adult GISTs lack oncogenic mutations in KIT and PDGFRA. The results of tyrosine kinase inhibitor therapy in GIST cases with SDH deficiency are limited and controversial. Here, we would like to present a pediatric SDH deficient GIST case treated with surgery and Imatinib Mesylate. We obtained a good response with Imatinib Mesylate.http://www.sciencedirect.com/science/article/pii/S2531137922013931 |
| spellingShingle | Melek Yaman Ortakoylu Sonay Incesoy Ozdemir Handan Dincaslan Nurdan Tacyildiz Isınsu Kuzu Emel Cabi Unal SUCCINATE DEHYDROGENASE SUBUNIT B DEFICIENT PEDIATRIC GIST Hematology, Transfusion and Cell Therapy |
| title | SUCCINATE DEHYDROGENASE SUBUNIT B DEFICIENT PEDIATRIC GIST |
| title_full | SUCCINATE DEHYDROGENASE SUBUNIT B DEFICIENT PEDIATRIC GIST |
| title_fullStr | SUCCINATE DEHYDROGENASE SUBUNIT B DEFICIENT PEDIATRIC GIST |
| title_full_unstemmed | SUCCINATE DEHYDROGENASE SUBUNIT B DEFICIENT PEDIATRIC GIST |
| title_short | SUCCINATE DEHYDROGENASE SUBUNIT B DEFICIENT PEDIATRIC GIST |
| title_sort | succinate dehydrogenase subunit b deficient pediatric gist |
| url | http://www.sciencedirect.com/science/article/pii/S2531137922013931 |
| work_keys_str_mv | AT melekyamanortakoylu succinatedehydrogenasesubunitbdeficientpediatricgist AT sonayincesoyozdemir succinatedehydrogenasesubunitbdeficientpediatricgist AT handandincaslan succinatedehydrogenasesubunitbdeficientpediatricgist AT nurdantacyildiz succinatedehydrogenasesubunitbdeficientpediatricgist AT isınsukuzu succinatedehydrogenasesubunitbdeficientpediatricgist AT emelcabiunal succinatedehydrogenasesubunitbdeficientpediatricgist |