Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection
Toxoplasma gondii is an exceptionally successful parasite that infects a very broad host range, including humans, across the globe. The outcome of infection differs remarkably between hosts, ranging from acute death to sterile infection. These differential disease patterns are strongly influenced by...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-10-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcimb.2020.580425/full |
| _version_ | 1818341489384620032 |
|---|---|
| author | Debanjan Mukhopadhyay David Arranz-Solís Jeroen P. J. Saeij |
| author_facet | Debanjan Mukhopadhyay David Arranz-Solís Jeroen P. J. Saeij |
| author_sort | Debanjan Mukhopadhyay |
| collection | DOAJ |
| description | Toxoplasma gondii is an exceptionally successful parasite that infects a very broad host range, including humans, across the globe. The outcome of infection differs remarkably between hosts, ranging from acute death to sterile infection. These differential disease patterns are strongly influenced by both host- and parasite-specific genetic factors. In this review, we discuss how the clinical outcome of toxoplasmosis varies between hosts and the role of different immune genes and parasite virulence factors, with a special emphasis on Toxoplasma-induced ileitis and encephalitis. |
| first_indexed | 2024-12-13T15:59:36Z |
| format | Article |
| id | doaj.art-7e1d7cf668e94118b20f3a294b41695d |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-13T15:59:36Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-7e1d7cf668e94118b20f3a294b41695d2022-12-21T23:39:13ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-10-011010.3389/fcimb.2020.580425580425Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma InfectionDebanjan MukhopadhyayDavid Arranz-SolísJeroen P. J. SaeijToxoplasma gondii is an exceptionally successful parasite that infects a very broad host range, including humans, across the globe. The outcome of infection differs remarkably between hosts, ranging from acute death to sterile infection. These differential disease patterns are strongly influenced by both host- and parasite-specific genetic factors. In this review, we discuss how the clinical outcome of toxoplasmosis varies between hosts and the role of different immune genes and parasite virulence factors, with a special emphasis on Toxoplasma-induced ileitis and encephalitis.https://www.frontiersin.org/article/10.3389/fcimb.2020.580425/fullToxoplasmaimmune responsestrainvirulence factorileitisencephalitis |
| spellingShingle | Debanjan Mukhopadhyay David Arranz-Solís Jeroen P. J. Saeij Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection Frontiers in Cellular and Infection Microbiology Toxoplasma immune response strain virulence factor ileitis encephalitis |
| title | Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection |
| title_full | Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection |
| title_fullStr | Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection |
| title_full_unstemmed | Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection |
| title_short | Influence of the Host and Parasite Strain on the Immune Response During Toxoplasma Infection |
| title_sort | influence of the host and parasite strain on the immune response during toxoplasma infection |
| topic | Toxoplasma immune response strain virulence factor ileitis encephalitis |
| url | https://www.frontiersin.org/article/10.3389/fcimb.2020.580425/full |
| work_keys_str_mv | AT debanjanmukhopadhyay influenceofthehostandparasitestrainontheimmuneresponseduringtoxoplasmainfection AT davidarranzsolis influenceofthehostandparasitestrainontheimmuneresponseduringtoxoplasmainfection AT jeroenpjsaeij influenceofthehostandparasitestrainontheimmuneresponseduringtoxoplasmainfection |