Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex

Acute stress impairs sensorimotor gating via the neurosteroid allopregnanolone in the prefrontal cortex

Ample evidence indicates that environmental stress impairs information processing, yet the underlying mechanisms remain partially elusive. We showed that, in several rodent models of psychopathology, the neurosteroid allopregnanolone (AP) reduces the prepulse inhibition (PPI) of the startle, a well-...

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Bibliographic Details
Main Authors: Roberto Cadeddu, Laura J. Mosher, Peter Nordkild, Nilesh Gaikwad, Gian Michele Ratto, Simona Scheggi, Marco Bortolato
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Neurobiology of Stress
Subjects:
Acute stress
Allopregnanolone
Medial prefrontal cortex
Prepulse inhibition
Animal models
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289522000649

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