Effect of repeated intravitreal Ranibizumab and Aflibercept injections on the corneal nerves in patients with macular edema
AIM: To investigate the effect of repeated intravitreal injection of ranibizumab and aflibercept on corneal nerve of patients with macular edema.METHODS: A total of 64 patients(64 eyes)enrolled in our hospital from June 2021 to June 2022 were treated with intravitreal injection of anti-vascular endo...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2023-05-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2023/5/202305025.pdf |
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| author | Yuan-Yuan Qi Lin Cui Li Zhang Yao Jiang Li-Li Ji Yuan-Yuan Qiu Chun-Xiao Yan Li-Jun Zhang |
| author_facet | Yuan-Yuan Qi Lin Cui Li Zhang Yao Jiang Li-Li Ji Yuan-Yuan Qiu Chun-Xiao Yan Li-Jun Zhang |
| author_sort | Yuan-Yuan Qi |
| collection | DOAJ |
| description | AIM: To investigate the effect of repeated intravitreal injection of ranibizumab and aflibercept on corneal nerve of patients with macular edema.METHODS: A total of 64 patients(64 eyes)enrolled in our hospital from June 2021 to June 2022 were treated with intravitreal injection of anti-vascular endothelial growth factor(VEGF). There were 20 cases(20 eyes)of diabetic macular edema, 19 cases(19 eyes)of wet age-related macular degeneration and 25 cases(25 eyes)of retinal vein occlusion. Corneal confocal microscope was used to collect images of corneal subbasal nerve plexus before injections and at 1mo after each intravitreal injection based on 3+pro re nata(PRN)treatment regimen. Furthermore, the length and density of corneal nerve were measured.RESULTS: There was no significant difference in corneal nerve density of patients injected with aflibercept between pre-injection and post-injection(P>0.05), while the corneal nerve length after 2nd and 3rd injections was lower than that of pre-injection(all P<0.01). There were no significant changes in corneal nerve density and length in patients with intravitreal injections of ranibizumab(all P>0.05), and there was no significant differences in corneal nerve density and length after 3 injections of the two drugs(all P>0.05).CONCLUSION: Repeated intravitreal anti-VEGF drug may affect corneal nerve to some extent. For patients who need repeated intravitreal injections of anti-VEGF, attention should be paid to the changes of corneal nerves. |
| first_indexed | 2024-04-09T15:32:22Z |
| format | Article |
| id | doaj.art-7e2079d54c2649c3973b158e37ddcc68 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-04-09T15:32:22Z |
| publishDate | 2023-05-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-7e2079d54c2649c3973b158e37ddcc682023-04-28T06:27:01ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232023-05-0123584885110.3980/j.issn.1672-5123.2023.5.25202305025Effect of repeated intravitreal Ranibizumab and Aflibercept injections on the corneal nerves in patients with macular edemaYuan-Yuan Qi0Lin Cui1Li Zhang2Yao Jiang3Li-Li Ji4Yuan-Yuan Qiu5Chun-Xiao Yan6Li-Jun Zhang7Department of Ophthalmology, Dalian No.3 People's Hospital Affiliated to Dalian Medical University;Key Laboratory of Corneal and Ocular Surface Diseases Research of Liaoning Province, Dalian 116033, Liaoning Province, China; Dalian Medical University, Dalian 116044, Liaoning Province, ChinaDepartment of Ophthalmology, Dalian No.3 People's Hospital Affiliated to Dalian Medical University;Key Laboratory of Corneal and Ocular Surface Diseases Research of Liaoning Province, Dalian 116033, Liaoning Province, ChinaDepartment of Ophthalmology, Dalian No.3 People's Hospital Affiliated to Dalian Medical University;Key Laboratory of Corneal and Ocular Surface Diseases Research of Liaoning Province, Dalian 116033, Liaoning Province, ChinaDepartment of Ophthalmology, Dalian No.3 People's Hospital Affiliated to Dalian Medical University;Key Laboratory of Corneal and Ocular Surface Diseases Research of Liaoning Province, Dalian 116033, Liaoning Province, ChinaDepartment of Ophthalmology, Dalian No.3 People's Hospital Affiliated to Dalian Medical University;Key Laboratory of Corneal and Ocular Surface Diseases Research of Liaoning Province, Dalian 116033, Liaoning Province, ChinaDepartment of Ophthalmology, Dalian No.3 People's Hospital Affiliated to Dalian Medical University;Key Laboratory of Corneal and Ocular Surface Diseases Research of Liaoning Province, Dalian 116033, Liaoning Province, ChinaDepartment of Ophthalmology, Dalian No.3 People's Hospital Affiliated to Dalian Medical University;Key Laboratory of Corneal and Ocular Surface Diseases Research of Liaoning Province, Dalian 116033, Liaoning Province, ChinaDepartment of Ophthalmology, Dalian No.3 People's Hospital Affiliated to Dalian Medical University;Key Laboratory of Corneal and Ocular Surface Diseases Research of Liaoning Province, Dalian 116033, Liaoning Province, China; Dalian Medical University, Dalian 116044, Liaoning Province, ChinaAIM: To investigate the effect of repeated intravitreal injection of ranibizumab and aflibercept on corneal nerve of patients with macular edema.METHODS: A total of 64 patients(64 eyes)enrolled in our hospital from June 2021 to June 2022 were treated with intravitreal injection of anti-vascular endothelial growth factor(VEGF). There were 20 cases(20 eyes)of diabetic macular edema, 19 cases(19 eyes)of wet age-related macular degeneration and 25 cases(25 eyes)of retinal vein occlusion. Corneal confocal microscope was used to collect images of corneal subbasal nerve plexus before injections and at 1mo after each intravitreal injection based on 3+pro re nata(PRN)treatment regimen. Furthermore, the length and density of corneal nerve were measured.RESULTS: There was no significant difference in corneal nerve density of patients injected with aflibercept between pre-injection and post-injection(P>0.05), while the corneal nerve length after 2nd and 3rd injections was lower than that of pre-injection(all P<0.01). There were no significant changes in corneal nerve density and length in patients with intravitreal injections of ranibizumab(all P>0.05), and there was no significant differences in corneal nerve density and length after 3 injections of the two drugs(all P>0.05).CONCLUSION: Repeated intravitreal anti-VEGF drug may affect corneal nerve to some extent. For patients who need repeated intravitreal injections of anti-VEGF, attention should be paid to the changes of corneal nerves.http://ies.ijo.cn/cn_publish/2023/5/202305025.pdfvascular endothelial growth factorcorneaconfocal microscopenerve lengthnerve densityranibizumabaflibercept |
| spellingShingle | Yuan-Yuan Qi Lin Cui Li Zhang Yao Jiang Li-Li Ji Yuan-Yuan Qiu Chun-Xiao Yan Li-Jun Zhang Effect of repeated intravitreal Ranibizumab and Aflibercept injections on the corneal nerves in patients with macular edema Guoji Yanke Zazhi vascular endothelial growth factor cornea confocal microscope nerve length nerve density ranibizumab aflibercept |
| title | Effect of repeated intravitreal Ranibizumab and Aflibercept injections on the corneal nerves in patients with macular edema |
| title_full | Effect of repeated intravitreal Ranibizumab and Aflibercept injections on the corneal nerves in patients with macular edema |
| title_fullStr | Effect of repeated intravitreal Ranibizumab and Aflibercept injections on the corneal nerves in patients with macular edema |
| title_full_unstemmed | Effect of repeated intravitreal Ranibizumab and Aflibercept injections on the corneal nerves in patients with macular edema |
| title_short | Effect of repeated intravitreal Ranibizumab and Aflibercept injections on the corneal nerves in patients with macular edema |
| title_sort | effect of repeated intravitreal ranibizumab and aflibercept injections on the corneal nerves in patients with macular edema |
| topic | vascular endothelial growth factor cornea confocal microscope nerve length nerve density ranibizumab aflibercept |
| url | http://ies.ijo.cn/cn_publish/2023/5/202305025.pdf |
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