Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer

Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer

It is evident that regions within tumors are deprived of oxygen, which makes the microenvironment hypoxic. Cancer cells experiencing hypoxia undergo metabolic alterations and cytoprotective adaptive mechanisms to survive such stringent conditions. While such mechanisms provide potential therapeutic...

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Bibliographic Details
Main Authors: Sandhya Chipurupalli, Elango Kannan, Vinay Tergaonkar, Richard D’Andrea, Nirmal Robinson
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
hypoxia
endoplasmic reticulum
UPR
cancer
HIF-1
stress-response
Online Access:https://www.mdpi.com/1422-0067/20/3/749

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