Human umbilical cord mesenchymal stem cells induction in peri-implantitis Rattus norvegicus accelerates and enhances osteogenesis activity and implant osseointegration
Background: Peri-implantitis additional treatment generally aims to repair damaged tissue through a regenerative approach. Human umbilical cord mesenchymal stem cells (hUCMSCs) produce a high osteogenic effect and are capable of modulating the immune system by suppressing inflammatory response, modu...
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Format: | Article |
Language: | English |
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Elsevier
2023-02-01
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Series: | Saudi Dental Journal |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905223000032 |
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author | Nike Hendrijantini Mefina Kuntjoro Bambang Agustono Ratri Maya Sitalaksmi Muhammad Dimas Aditya Ari Marcella Theodora Rudy Effendi Ivan Setiawan Djuarsa Jennifer Widjaja Agung Sosiawan Guang Hong |
author_facet | Nike Hendrijantini Mefina Kuntjoro Bambang Agustono Ratri Maya Sitalaksmi Muhammad Dimas Aditya Ari Marcella Theodora Rudy Effendi Ivan Setiawan Djuarsa Jennifer Widjaja Agung Sosiawan Guang Hong |
author_sort | Nike Hendrijantini |
collection | DOAJ |
description | Background: Peri-implantitis additional treatment generally aims to repair damaged tissue through a regenerative approach. Human umbilical cord mesenchymal stem cells (hUCMSCs) produce a high osteogenic effect and are capable of modulating the immune system by suppressing inflammatory response, modulating bone resorption, and inducing endogenous osteogenesis. Aim: This study was intended to discover the effect of hUCMSCs on an implant osseointegration process in peri-implantitis rat subjects as assessed by several markers including interleukin-10 (IL-10), transforming growth factor-β (TGF-β), receptor activator of nuclear factor kappa- β ligand (RANKL), bone morphogenic protein (BMP-2), osterix (Osx), and osteoprotegerin (OPG). Material and methods: The research design implemented during this study represented a true experimental design incorporating the use of Rattus norvegicus (Wistar strain) as subjects. Results: Data analysed by means of a Brown Forsythe test indicated differences between the increase in BMP-2 expression (p < 0.000) and Osx expression (p < 0.001) and between RANKL expression (p < 0.001, Tukey HSD) and OPG expression (p < 0.000, Games Howell). Conclusion: According to the findings of this research, hUCMSCs induction is successful in accelerating and enhancing osteogenic activity and implant osseointegration in peri-implantitis rat subjects. |
first_indexed | 2024-04-10T06:05:26Z |
format | Article |
id | doaj.art-7e21a0de7a38419dad5fe997c0a97cc7 |
institution | Directory Open Access Journal |
issn | 1013-9052 |
language | English |
last_indexed | 2024-04-10T06:05:26Z |
publishDate | 2023-02-01 |
publisher | Elsevier |
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series | Saudi Dental Journal |
spelling | doaj.art-7e21a0de7a38419dad5fe997c0a97cc72023-03-03T04:23:29ZengElsevierSaudi Dental Journal1013-90522023-02-01352147153Human umbilical cord mesenchymal stem cells induction in peri-implantitis Rattus norvegicus accelerates and enhances osteogenesis activity and implant osseointegrationNike Hendrijantini0Mefina Kuntjoro1Bambang Agustono2Ratri Maya Sitalaksmi3Muhammad Dimas Aditya Ari4Marcella Theodora5Rudy Effendi6Ivan Setiawan Djuarsa7Jennifer Widjaja8Agung Sosiawan9Guang Hong10Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia; Corresponding author.Department of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Prosthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaDepartment of Dental Public Health, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, IndonesiaDivision for Globalization Initiative, Graduate School of Dentistry, Tohoku University, Sendai, JapanBackground: Peri-implantitis additional treatment generally aims to repair damaged tissue through a regenerative approach. Human umbilical cord mesenchymal stem cells (hUCMSCs) produce a high osteogenic effect and are capable of modulating the immune system by suppressing inflammatory response, modulating bone resorption, and inducing endogenous osteogenesis. Aim: This study was intended to discover the effect of hUCMSCs on an implant osseointegration process in peri-implantitis rat subjects as assessed by several markers including interleukin-10 (IL-10), transforming growth factor-β (TGF-β), receptor activator of nuclear factor kappa- β ligand (RANKL), bone morphogenic protein (BMP-2), osterix (Osx), and osteoprotegerin (OPG). Material and methods: The research design implemented during this study represented a true experimental design incorporating the use of Rattus norvegicus (Wistar strain) as subjects. Results: Data analysed by means of a Brown Forsythe test indicated differences between the increase in BMP-2 expression (p < 0.000) and Osx expression (p < 0.001) and between RANKL expression (p < 0.001, Tukey HSD) and OPG expression (p < 0.000, Games Howell). Conclusion: According to the findings of this research, hUCMSCs induction is successful in accelerating and enhancing osteogenic activity and implant osseointegration in peri-implantitis rat subjects.http://www.sciencedirect.com/science/article/pii/S1013905223000032Human umbilical cord mesenchymal stem cellsImplantOsseointegrationPeri-implantitisMedicine |
spellingShingle | Nike Hendrijantini Mefina Kuntjoro Bambang Agustono Ratri Maya Sitalaksmi Muhammad Dimas Aditya Ari Marcella Theodora Rudy Effendi Ivan Setiawan Djuarsa Jennifer Widjaja Agung Sosiawan Guang Hong Human umbilical cord mesenchymal stem cells induction in peri-implantitis Rattus norvegicus accelerates and enhances osteogenesis activity and implant osseointegration Saudi Dental Journal Human umbilical cord mesenchymal stem cells Implant Osseointegration Peri-implantitis Medicine |
title | Human umbilical cord mesenchymal stem cells induction in peri-implantitis Rattus norvegicus accelerates and enhances osteogenesis activity and implant osseointegration |
title_full | Human umbilical cord mesenchymal stem cells induction in peri-implantitis Rattus norvegicus accelerates and enhances osteogenesis activity and implant osseointegration |
title_fullStr | Human umbilical cord mesenchymal stem cells induction in peri-implantitis Rattus norvegicus accelerates and enhances osteogenesis activity and implant osseointegration |
title_full_unstemmed | Human umbilical cord mesenchymal stem cells induction in peri-implantitis Rattus norvegicus accelerates and enhances osteogenesis activity and implant osseointegration |
title_short | Human umbilical cord mesenchymal stem cells induction in peri-implantitis Rattus norvegicus accelerates and enhances osteogenesis activity and implant osseointegration |
title_sort | human umbilical cord mesenchymal stem cells induction in peri implantitis rattus norvegicus accelerates and enhances osteogenesis activity and implant osseointegration |
topic | Human umbilical cord mesenchymal stem cells Implant Osseointegration Peri-implantitis Medicine |
url | http://www.sciencedirect.com/science/article/pii/S1013905223000032 |
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