The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer
Abstract Background Both preoperative cardiopulmonary exercise test (CPET)-derived measures of fitness and postoperative C-reactive protein (CRP) concentrations are associated with complications following surgery for colorectal cancer. The aim of the present pilot study was to examine the relationsh...
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| Format: | Article |
| Language: | English |
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BMC
2018-06-01
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| Series: | Perioperative Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13741-018-0093-8 |
| _version_ | 1828163702437707776 |
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| author | Stephen T. McSorley Campbell S. D. Roxburgh Paul G. Horgan Donald C. McMillan |
| author_facet | Stephen T. McSorley Campbell S. D. Roxburgh Paul G. Horgan Donald C. McMillan |
| author_sort | Stephen T. McSorley |
| collection | DOAJ |
| description | Abstract Background Both preoperative cardiopulmonary exercise test (CPET)-derived measures of fitness and postoperative C-reactive protein (CRP) concentrations are associated with complications following surgery for colorectal cancer. The aim of the present pilot study was to examine the relationship between CPET and postoperative CRP concentrations in this patient group. Methods Patients who had undergone CPET prior to elective surgery for histologically confirmed colorectal cancer in a single centre between September 2008 and April 2017 were included. Preoperative VO2 at the anaerobic threshold (AT) and peak exercise were recorded, along with preoperative modified Glasgow Prognostic Score (mGPS) and CRP on each postoperative day. Results Thirty-eight patients were included. The majority were male (30, 79%), over 65 years old (30, 79%), with colonic cancer (23, 61%) and node-negative disease (24, 63%). Fourteen patients (37%) had open surgery and 24 (63%) had a laparoscopic resection. A progressive reduction in VO2 at peak exercise was significantly associated with both increasing American Society of Anesthesiology (ASA) grade (median, ml/kg/min: ASA 1 = 22, ASA 2 = 19, ASA 3 = 15, ASA 4 = 12, p = 0.014) and increasing mGPS (median, ml/kg/min: mGPS 0 = 18, mGPS 1 = 16, mGPS 2 = 14, p = 0.039) There was no significant association between either VO2 at the AT or peak exercise and postoperative CRP. Conclusions The present pilot study reports a possible association between preoperative CPET-derived measures of exercise tolerance, and the preoperative systemic inflammatory response, but not postoperative CRP in patients undergoing surgery for colorectal cancer. |
| first_indexed | 2024-04-12T01:14:31Z |
| format | Article |
| id | doaj.art-7e21da71bced4fb0b997ab8032aaf46f |
| institution | Directory Open Access Journal |
| issn | 2047-0525 |
| language | English |
| last_indexed | 2024-04-12T01:14:31Z |
| publishDate | 2018-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Perioperative Medicine |
| spelling | doaj.art-7e21da71bced4fb0b997ab8032aaf46f2022-12-22T03:54:01ZengBMCPerioperative Medicine2047-05252018-06-01711710.1186/s13741-018-0093-8The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancerStephen T. McSorley0Campbell S. D. Roxburgh1Paul G. Horgan2Donald C. McMillan3Academic Unit of Surgery, School of Medicine, University of GlasgowAcademic Unit of Surgery, School of Medicine, University of GlasgowAcademic Unit of Surgery, School of Medicine, University of GlasgowAcademic Unit of Surgery, School of Medicine, University of GlasgowAbstract Background Both preoperative cardiopulmonary exercise test (CPET)-derived measures of fitness and postoperative C-reactive protein (CRP) concentrations are associated with complications following surgery for colorectal cancer. The aim of the present pilot study was to examine the relationship between CPET and postoperative CRP concentrations in this patient group. Methods Patients who had undergone CPET prior to elective surgery for histologically confirmed colorectal cancer in a single centre between September 2008 and April 2017 were included. Preoperative VO2 at the anaerobic threshold (AT) and peak exercise were recorded, along with preoperative modified Glasgow Prognostic Score (mGPS) and CRP on each postoperative day. Results Thirty-eight patients were included. The majority were male (30, 79%), over 65 years old (30, 79%), with colonic cancer (23, 61%) and node-negative disease (24, 63%). Fourteen patients (37%) had open surgery and 24 (63%) had a laparoscopic resection. A progressive reduction in VO2 at peak exercise was significantly associated with both increasing American Society of Anesthesiology (ASA) grade (median, ml/kg/min: ASA 1 = 22, ASA 2 = 19, ASA 3 = 15, ASA 4 = 12, p = 0.014) and increasing mGPS (median, ml/kg/min: mGPS 0 = 18, mGPS 1 = 16, mGPS 2 = 14, p = 0.039) There was no significant association between either VO2 at the AT or peak exercise and postoperative CRP. Conclusions The present pilot study reports a possible association between preoperative CPET-derived measures of exercise tolerance, and the preoperative systemic inflammatory response, but not postoperative CRP in patients undergoing surgery for colorectal cancer.http://link.springer.com/article/10.1186/s13741-018-0093-8Colorectal cancerCardiopulmonary exercise testingSystemic inflammation |
| spellingShingle | Stephen T. McSorley Campbell S. D. Roxburgh Paul G. Horgan Donald C. McMillan The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer Perioperative Medicine Colorectal cancer Cardiopulmonary exercise testing Systemic inflammation |
| title | The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer |
| title_full | The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer |
| title_fullStr | The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer |
| title_full_unstemmed | The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer |
| title_short | The relationship between cardiopulmonary exercise test variables, the systemic inflammatory response, and complications following surgery for colorectal cancer |
| title_sort | relationship between cardiopulmonary exercise test variables the systemic inflammatory response and complications following surgery for colorectal cancer |
| topic | Colorectal cancer Cardiopulmonary exercise testing Systemic inflammation |
| url | http://link.springer.com/article/10.1186/s13741-018-0093-8 |
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