Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation
CARD9 and CARD11 propagate signaling by nucleating Bcl10 polymerization in immune cells and are both held in an autoinhibited state prior to activation. Here, the authors combine structural, biochemical, and cell-based approaches to reveal the structural basis for CARD9/11 autoinhibition and show th...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10953-z |
| _version_ | 1818427117272039424 |
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| author | Michael J. Holliday Axel Witt Alejandro Rodríguez Gama Benjamin T. Walters Christopher P. Arthur Randal Halfmann Alexis Rohou Erin C. Dueber Wayne J. Fairbrother |
| author_facet | Michael J. Holliday Axel Witt Alejandro Rodríguez Gama Benjamin T. Walters Christopher P. Arthur Randal Halfmann Alexis Rohou Erin C. Dueber Wayne J. Fairbrother |
| author_sort | Michael J. Holliday |
| collection | DOAJ |
| description | CARD9 and CARD11 propagate signaling by nucleating Bcl10 polymerization in immune cells and are both held in an autoinhibited state prior to activation. Here, the authors combine structural, biochemical, and cell-based approaches to reveal the structural basis for CARD9/11 autoinhibition and show that the two proteins are activated through similar but distinct mechanisms. |
| first_indexed | 2024-12-14T14:40:37Z |
| format | Article |
| id | doaj.art-7e23aebac6c444bc92a15b78399d9b56 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:40:37Z |
| publishDate | 2019-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7e23aebac6c444bc92a15b78399d9b562022-12-21T22:57:26ZengNature PortfolioNature Communications2041-17232019-07-0110111710.1038/s41467-019-10953-zStructures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activationMichael J. Holliday0Axel Witt1Alejandro Rodríguez Gama2Benjamin T. Walters3Christopher P. Arthur4Randal Halfmann5Alexis Rohou6Erin C. Dueber7Wayne J. Fairbrother8Early Discovery Biochemistry Department, GenentechEarly Discovery Biochemistry Department, GenentechStowers Institute for Medical ResearchBiochemical and Cellular Pharmacology Department, GenentechStructural Biology Department, GenentechStowers Institute for Medical ResearchStructural Biology Department, GenentechEarly Discovery Biochemistry Department, GenentechEarly Discovery Biochemistry Department, GenentechCARD9 and CARD11 propagate signaling by nucleating Bcl10 polymerization in immune cells and are both held in an autoinhibited state prior to activation. Here, the authors combine structural, biochemical, and cell-based approaches to reveal the structural basis for CARD9/11 autoinhibition and show that the two proteins are activated through similar but distinct mechanisms.https://doi.org/10.1038/s41467-019-10953-z |
| spellingShingle | Michael J. Holliday Axel Witt Alejandro Rodríguez Gama Benjamin T. Walters Christopher P. Arthur Randal Halfmann Alexis Rohou Erin C. Dueber Wayne J. Fairbrother Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation Nature Communications |
| title | Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation |
| title_full | Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation |
| title_fullStr | Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation |
| title_full_unstemmed | Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation |
| title_short | Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation |
| title_sort | structures of autoinhibited and polymerized forms of card9 reveal mechanisms of card9 and card11 activation |
| url | https://doi.org/10.1038/s41467-019-10953-z |
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